Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma

1. Is the biology right?

• Somatic driver evidence: yes · CRBN in plasma cell myeloma

  Rule: Open Targets has somatic-mutation evidence for the target in this cancer. Source: Open Targets: CRBN in plasma cell myeloma, 2026-11-11

  Published context: 2.3× relative success for targets with somatic (IntOGen) support in oncology (Minikel et al., Nature 2024, drug programs to 2023). A ratio between groups, not a probability for this program; mostly phase 2 to 3.
• Human genetic evidence: yes · CRBN: somatic

  Rule: Any germline or somatic human genetic evidence for the target in this cancer, counted apart from animal-model and literature evidence. Source: Open Targets: CRBN in plasma cell myeloma, 2026-11-11

  Published context: 2.6× relative probability of success, phase 1 to launch, with human genetic support (Minikel et al., Nature 2024, drug programs to 2023). All therapy areas, mostly germline evidence; not a probability for this program.
• Pediatric target: yes · CD38 on the FDA list

  Rule: Target is on FDA's Pediatric Molecular Target List (relevant targets); membership alone neither requires nor waives a study. Source: FDA Pediatric Molecular Target List (Listed as February 2026 on the FDA Pediatric Oncology page; the file served is 9.7.22_the_relevant_molecular_target_list.xlsx, whose Summary of Changes sheet is headed 'SEPTEMBER 2022 UPDATE' (footnote date 2022-09-01)), 2026-11-11
• Haematologic cancer: yes · Haematologic

  Rule: From the indication, or the registry conditions when no indication matches. Source: ClinicalTrials.gov NCT05896228, 2026-11-11

  Published context: Likelihood of approval from phase 1: 7.5% haematologic vs 4.6% solid (BIO / Informa / QLS 2021, 2011–2020). Population-level, not a prediction.

• CRBN (via Iberdomide): Evidence types in plasma cell myeloma: literature, affected_pathway, somatic_mutation, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, cancer_biomarkers, eva_somatic, europepmc. · Open Targets: CRBN in plasma cell myeloma
• DDB1 (via Iberdomide): Evidence types in plasma cell myeloma: literature, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, europepmc. · Open Targets: DDB1 in plasma cell myeloma
• CUL4A (via Iberdomide): Evidence types in plasma cell myeloma: literature, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, europepmc. · Open Targets: CUL4A in plasma cell myeloma
• PSMD1 (via Carfilzomib): Evidence types in plasma cell myeloma: literature, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, europepmc. · Open Targets: PSMD1 in plasma cell myeloma
• PSMB2 (via Carfilzomib): Evidence types in plasma cell myeloma: clinical. Datasources: clinical_precedence. · Open Targets: PSMB2 in plasma cell myeloma
• PSMB1 (via Carfilzomib): Evidence types in plasma cell myeloma: literature, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, europepmc. · Open Targets: PSMB1 in plasma cell myeloma
• CD38 (via Daratumumab): Evidence types in plasma cell myeloma: literature, clinical; literature listed separately from human genetics. Datasources: clinical_precedence, europepmc. · Open Targets: CD38 in plasma cell myeloma
• PTGS2 (via Acetaminophen): Evidence types in plasma cell myeloma: literature, animal_model, clinical; literature and animal_model listed separately from human genetics. Datasources: clinical_precedence, impc, europepmc. · Open Targets: PTGS2 in plasma cell myeloma
• PTGS1 (via Acetaminophen): Evidence types in plasma cell myeloma: clinical. Datasources: clinical_precedence. · Open Targets: PTGS1 in plasma cell myeloma
• FAAH (via Acetaminophen): Open Targets has no association between FAAH and plasma cell myeloma. · Open Targets: FAAH in plasma cell myeloma

• Not loaded on this app yet: Normal-tissue expression in vital organs. Source: Human Protein Atlas (ticket 36).
• Not loaded on this app yet: Pan-essential in cell lines. Source: DepMap (ticket 36).
• Not loaded on this app yet: Approved drug on this target. Source: Drugs@FDA (ticket 30).

2. Can the result be trusted?

• Randomised: no · Non-randomised

  Rule: Registry allocation field. Source: ClinicalTrials.gov NCT05896228, 2026-11-11
• Small denominator: no · 30 planned; each patient moves a rate by 100 ÷ 30 = 3.3 points

  Rule: Enrolment under 30; the arithmetic is shown, not a benchmark. Source: ClinicalTrials.gov NCT05896228, 2026-11-11
• Primary endpoint is overall survival: no · Rate of MRD-negativity: Iber-KDd Combination therapy.

  Rule: A registered primary outcome measure names overall survival. Source: ClinicalTrials.gov NCT05896228, 2026-11-11

  Published context: Non-OS primary endpoint: odds ratio 2.79 for a positive phase 3 (Otsuka 2021, 400 phase 3 oncology trials, to 2020). Shown with the next figure: a surrogate is easier to hit, and often a weak guide to survival.

  Published context: 52% of surrogate-to-OS correlations are low (Prasad 2015, published to 2014). Shown with the figure above.
• Results overdue: no · Primary completion expected 2029-03-01; not yet due

  Rule: Primary completion (actual) more than 12 months ago and no results posted to the registry. Source: ClinicalTrials.gov NCT05896228, 2026-11-11

• Not loaded on this app yet: Treated and evaluable counts, assessor, confirmed response, follow-up and data cutoff. Source: Readout extraction (ticket 32).
• Not loaded on this app yet: Primary endpoint changed between registry versions. Source: Registry versions in the store (ticket 32).

3. What must it beat?

• Not loaded on this app yet: Control-arm result and approved therapies for the same segment, with label links. Source: Drugs@FDA, FDA labels and readouts (tickets 30, 32).

4. Too crowded, or too late?

• Stopped on this target: 68 terminated, withdrawn or suspended trials of drugs against CRBN; 3 give no reason. Reasons are quoted as the registry gives them on the target page. · CRBN: what already stopped

• Not loaded on this app yet: Programs on the target by phase and months behind the leader. Source: Programs and Drugs@FDA (ticket 33).

5. Can it be approved, and stay approved?

• Single-country: yes · The only site is in United States

  Rule: All listed sites are in one country; the share of US sites is shown. Source: ClinicalTrials.gov NCT05896228, 2026-11-11
• EU paediatric investigation plan: yes · EMEA-002152-PIP01-17-M04 (daratumumab, Treatment of lymphoid malignancies (except mature B-cell neoplasms)): PM: decision on the application for modification of an agreed PIP, 13 Sept 2024; compliance positive 13 Dec 2024; EMEA-001806-PIP04-19-M02 (carfilzomib, Treatment of acute lymphoblastic leukaemia): PM: decision on the application for modification of an agreed PIP, 27 Oct 2023; EMEA-002152-PIP03-19 (daratumumab, Treatment of systemic light chain amyloidosis): W: decision granting a waiver in all age groups for all conditions or indications, 18 Mar 2020; EMEA-002636-PIP01-19 (Iberdomide, Treatment of mature B-cell neoplasms): W: decision granting a waiver in all age groups for all conditions or indications, 3 Jan 2020; +2 more

  Rule: An EMA PIP decision (agreement, modification or waiver) lists the drug as its active substance, exact name. Source: EMA data download (dated snapshot), 2026-11-11
• EU orphan designation: yes · EU/3/18/2020 withdrawn 25 May 2018: Treatment of AL amyloidosis; EU/3/13/1153 expired 17 Jul 2013: Treatment of plasma-cell myeloma; EU/3/08/548 expired 3 Jun 2008: Treatment of multiple myeloma

  Rule: An EU orphan designation lists the drug as its active substance (exact name) or belongs to a medicine that does; withdrawn and expired designations are listed with their status. Source: EMA data download (dated snapshot), 2026-11-11
• Authorised in the EU: yes · Darzalex: authorised since 20 May 2016; Kyprolis: authorised since 19 Nov 2015

  Rule: An EMA medicine record lists the drug as its active substance or INN, exact name; national-only authorisations are not in this file. Source: EMA data download (dated snapshot), 2026-11-11
• FDA orphan designation: not published · FDA's orphan designation database turns away automated requests, so this app does not read it; search it by hand at the link

  Rule: Would be: an FDA orphan designation names the drug. Source: FDA orphan designations search
• FDA pediatric oncology approval: no · FDA's table lists no pediatric approval of Iberdomide, Carfilzomib, Daratumumab, Acetaminophen

  Rule: FDA's Pediatric Oncology Drug Approvals table names the drug. Source: FDA Pediatric Oncology Drug Approvals (content current as of 2026-03-03), 2026-11-11
• Registered studies open to children: yes · 442 interventional studies of Iberdomide, Carfilzomib, Daratumumab, Acetaminophen include patients under 18; 75 are recruiting, not yet recruiting or active

  Rule: The registry's age group includes Child (birth to 17 years), which also counts studies that set no minimum age. Source: ClinicalTrials.gov search, 2026-11-11

• Caveat: Site counts are not patients per country, and trials registered only outside ClinicalTrials.gov are not covered. Where the sites are is a fact about the record, not a judgement of its quality.
• Rare pediatric disease voucher: FDA, content current as of 29 Apr 2026: “As of February 3, 2026, enactment of the Consolidated Appropriations Act, 2026, the rare pediatric disease PRV program will sunset after September 30, 2029. FDA may not award any PRVs under this program after September 30, 2029.” Voucher sale prices are not shown here; they appear only as company-reported news. · FDA: Rare Pediatric Disease Designation and Priority Review Voucher Programs

• Not loaded on this app yet: Precedent approvals for target, modality and endpoint; accelerated-approval status. Source: Drugs@FDA and FDA accelerated-approval tables (ticket 30).

6. Can the sponsor finish?

• Sponsor: Benjamin T Diamond, MD (academic or other) · ClinicalTrials.gov NCT05896228
• principal investigator: Carl O Landgren, MD, PhD, University of Miami · Person page
• principal investigator: Benjamin Diamond, MD, University of Miami · Person page

• Not loaded on this app yet: Filed cash, quarterly spend and the runway arithmetic. Source: SEC XBRL company facts (ticket 37).
• Not loaded on this app yet: Sponsor's completed vs stopped oncology trials and results-reporting record. Source: Registry, by company (ticket 37).

What public data cannot tell you

Public records cannot show: sales forecasts; a probability of success for this asset; full deal terms and net prices; FDA designations and action dates before approval (shown only as company-reported); clinical holds unless the company disclosed them; manufacturing; patents on unapproved drugs; whether preclinical findings have been replicated.