Indications / Non-small cell lung cancer · Breast cancer · Pancreatic cancer · Colorectal cancer · Acute myeloid leukemia · Chronic myeloid leukemia · Multiple myeloma · Glioblastoma · Glioma · Neuroblastoma · Medulloblastoma · Diffuse midline glioma (DIPG) · Ependymoma · Atypical teratoid rhabdoid tumour (AT/RT) · Childhood acute lymphoblastic leukemia · Ewing sarcoma · Osteosarcoma · Rhabdomyosarcoma
Breast cancer
HR+/HER2-, HER2-low and TNBC: CDK4/6, oral SERDs, PI3K pathway and TROP2 ADCs.
ASCO Annual Meeting 2026
29 May – 2 Jun 2026, Chicago · Journal of Clinical Oncology 44 (16_suppl; LBAs in 17_suppl)
All 7,222 regular abstracts and 60 late-breaking abstracts have JCO supplement DOIs in Crossref.
Indexed in Crossref
191 abstracts matching breast cancer from the meeting's journal supplement, fetched live from Crossref 2026-11-12 09:58 UTC. This is a keyword search, not the complete abstract book.
- E23412
- E12680Real-world outcomes in triple negative breast cancer (TNBC) in patients with residual disease after neoadjuvant therapy (NEOCAPE).Adrian Wong, Alyssa Francis, Jessica Rodrigues, Bader Alshamsan et al.
- E12674Impact of neoadjuvant immunotherapy on safety of axillary de-escalation in triple-negative breast cancer (TNBC): A propensity score–matched analysis.Zheng Qu, Zheng Li, Hongzhe Zhang, Jennifer Q. Zhang et al.
- E13724Racial and ethnic differences in breast-conserving surgery after neoadjuvant chemotherapy for HER2-positive and triple-negative breast cancer.Alanna J. Hickey, Fangbai Sun, Fangyong Li, Ellie Proussaloglou et al.
- E13124Comparative efficacy and safety of novel agents versus standard chemotherapy in first-line (1L) locally advanced or metastatic triple-negative breast cancer (TNBC): A systematic review and network meta-analyses.Aneeta Channar, Arifa Bibi, Sumeeta Bhogal, Ramsha Zardari et al.
- E12548Real-world outcomes and cross-resistance of sequential antibody-drug conjugate therapy in HER2-low and triple-negative breast cancer: A systematic review.Trishtha Agarwal, Jay Desai, Kaandeeban Mohanraj, Harini Raj Shankar Raj
- 2602Safety and efficacy of intratumoral (IT) ruxotemitide (LTX 315) in combination with pembrolizumab in patients with unresectable advanced melanoma or triple-negative breast cancer (TNBC).Stephane Dalle, James F. Spicer, Adi Diab, Toby Batten et al.
- E12678Treatment patterns and clinical outcomes in patients with triple-negative breast cancer (TNBC) and residual disease (RD) after neoadjuvant chemoimmunotherapy.Nadia Bianco, Carmine Valenza, Monica Milano, Riccardo Asnaghi et al.
- 2524Phase 1b dose-expansion study of IMC-002, a anti-CD47 monoclonal antibody, in patients with advanced triple negative breast cancer (TNBC).Ji Hyung Hong, Keun Seok Lee, Sung Hoon Sim, Kyung Hae Jung et al.
- E12735Adjuvant (Ad) and neoadjuvant (NAd) strategies in higher risk hormone receptor–positive (HR+)/HER2-negative (HER2−) early breast cancer (EBC): Moroccan real-world outcomes.Hassan Abdelilah Tafenzi, Youssef AIT Takniouine, Farah Choulli, Ismail Essadi et al.
- E12723
- LBA1003Izalontamab brengitecan (iza-bren) versus physician’s choice of chemotherapy in patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC): A randomized phase III study.Jiong Wu, Jian Zhang, Quchang Ouyang, Yiqun Du et al.
- 543Real-world effectiveness and safety of adjuvant capecitabine in triple-negative breast cancer (TNBC) patients with residual disease following neoadjuvant chemotherapy.Anbarasan Sekar, Sanjana Malokar, Sushmita Rath, Prabhat Ghanshyam Bhargava et al.
- E13110Aromatase independent estradiol synthesis in triple-negative breast cancer cells.Andrew P. Jackson, Jennifer Yannucci, Himangshu Bose
- TPS659Pre-operative chemotherapy versus surgery first with peri-operative interventions in early triple-negative and HER2-positive breast cancer: An open-label, phase 3, randomized controlled trial (PRaCTiSE).Shalaka Prakash Joshi, Rohini W. Hawaldar, Vaibhav Vanmali, Ashwini Dewade et al.
- 1026Development and evaluation of a novel digital pathology image analysis pipeline for prediction of clinical outcomes with the TROP2-directed antibody-drug conjugate (ADC) sacituzumab tirumotecan (sac-TMT) in triple-negative breast cancer (TNBC).Sara M. Tolaney, John Kang, Jeong Hwan Kook, Zhongliang Zhou et al.
- E12660T-cell receptor (TCR) repertoire dynamics of response to neoadjuvant chemo-immunotherapy in triple- negative breast cancer (TNBC).Nickolas Stabellini, Prerana Parthasarathy Bangalore, Iluja Gautam, Pat A. Rayman et al.
- 3034
- E13127Neoadjuvant systemic therapy for triple-negative breast cancer: A safety-net health system’s experience.Prisca Mbonu, Rajnandini Aswani, Kalyani Narra
- E12728
- E13130
- E12624De-escalation of axillary surgery in clinically node-negative early-stage HR-positive, HER2-negative breast cancer.Petr Krivorotko, Arina Gorina, Alexander Emelyanov, Tengiz Tabagua et al.
- E12583AI-based assessment of tumor-infiltrating lymphocytes (TILs) in patients with triple-negative breast cancer (TNBC) receiving neoadjuvant chemotherapy versus chemo-immunotherapy.Ilana Schlam, Khalid AbdulJabbar, Hillary Heiling, Haixi Yan et al.
- 1125Real-world evaluation of CXCL9/10 with PD-L1 and TMB as predictors of pembrolizumab benefit in triple-negative breast cancer (TNBC).Shipra Gandhi, Sachin Kumar Deshmukh, Madison T. Canning, Dario Trapani et al.
- 576ILCness to stratify lobular-like breast cancer biology and as an outcome independent of CDH1 mutation in early ER-positive/HER2-negative breast cancer.Masanori Oshi, Sasagu Kurozumi, Mayu Hizume, Akimitsu Yamada et al.
- E13034
- E12650Integrative spatial omics to identify determinants of response to neoadjuvant chemo-immunotherapy in triple-negative breast cancer.Chi-Cheng Huang, Chih-Yi Hsu, Ling-Ming Tseng
- E12664Determinants of pathologic complete response in early-stage triple-negative breast cancer at a single institution.Peter Egwom, Aparna Nanduru, Rishitha Mantri, Seyon Chung et al.
- E12592Association of Schwann cells with immune-cold tumor microenvironment in triple-negative breast cancer.Kei Kawashima, Masanori Oshi, Akimitsu Yamada, Kazutaka Narui et al.
- E14564
- E12639
- E13528Early deviations from guideline-concordant care in triple-negative breast cancer: A patient-reported analysis.Rebekkah Schear, Marcela Mazo- Canola, Laura Housman, Kandis Backus et al.
- E12712Refusal of chemotherapy, surgery, and radiation in non-metastatic triple-negative breast cancer.Shawn Michael Doss, Rebecca Mai, Alicia H. Arnold, Danny Yakoub et al.
- E12703Benefit of chemotherapy on survival in women aged ≥ 70 with HR-positive, HER2-negative breast cancer and N2-like nodal burden: A population-based analysis.Noor Khalid, Mohammad Baraa Boozo, Waqas Azhar
- E24073Palliative care utilization in metastatic triple-negative breast cancer: A National Cancer Database analysis.Cher Ying Foo, Ojasav Sehrawat, Waqar Haque, Akshjot Puri et al.
- E13117Triple-negative breast cancer: Real-world evidence from a national oncologic reference center in Panama.Ricardo Gollini, Moises Cukier, Rodrigo DeAntonio, Joel Alexander Moreno Rios et al.
- E12710Age-related immune toxicity and treatment outcomes in triple-negative breast cancer treated with pembrolizumab.Grace Gorecki, Oyepeju Folashade Abioye, Bana Antonios, Colin Eamon Champ et al.
- 1099
- E12715Real-world outcomes of neoadjuvant chemo-immunotherapy in triple-negative breast cancer at a safety-net institution.Marian M. Varda, Daniel Park, Julia Lynch, Andrew Hwang et al.
- 1002First-line datopotamab deruxtecan (Dato-DXd) vs chemotherapy in patients with locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC) for whom immunotherapy was not an option: Additional efficacy endpoints from the TROPION-Breast02 study.David W. Cescon, Tiffany A. Traina, Peter Schmid, Javier Cortes et al.
- 3093Chemotherapy as a shaper of immune communication in the triple-negative breast cancer microenvironment.David Otohinoyi, Sravya Sri Kuchipudi, Archa Rajesh, Precious Idogun et al.
- E13132Association of triple-negative breast cancer with decreased T score of femoral neck at the time of osseous metastasis.Jean Schneider, Young Jin Suh, young Yi An, Hyun Joo Choi
- 1014ASCENT-03: Efficacy by biomarker subgroup with sacituzumab govitecan (SG) vs chemotherapy (chemo) in participants (pts) with previously untreated advanced triple-negative breast cancer (TNBC) who are not candidates for PD-(L)1 inhibitors (PD-[L]1i).Carlos H. Barrios, Sara A. Hurvitz, Sara M. Tolaney, Javier Cortes et al.
- E12751Factors associated with clinical presentation and survival in early-onset triple-negative breast cancer: A real-world analysis.Shawn Michael Doss, Rebecca Mai, Alicia H. Arnold, Danny Yakoub et al.
- E12652Clinically significant immune-related adverse events with perioperative pembrolizumab in early triple-negative breast cancer: Analysis of trial and real-world evidence.Sheikh Abdullah, Rajan Desai, Mariana Marrero Castillo
- E12501Spatial transcriptome to identify biomarkers for endocrine sensitivity of hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer (EBC).Yujing Tan, Jiani Wang, Ying Fan, Binghe Xu et al.
- E12559Predictive and prognostic value of MRI radiomics in patients with hormone-receptor–positive, HER2-negative breast cancer: A multicenter study.Qinmei Xu, Vincent Reid, Bradley Feiger, John A. Cole et al.
- E12633Evaluating physician perspectives on neoadjuvant immunotherapy and chemotherapy in early-stage triple-negative breast cancer.Alyssa Francis, Sharon McGee, Terry L. Ng, Mark J. Clemons et al.
- E12589Predictive value of PET-CT and tumor biology for pathological complete response in triple-negative breast cancer treated with neoadjuvant pembrolizumab: A real-world analysis.Niranjan Vijayaraghavan, Sankar Srinivasan, Kritthivasan Venkatakrishnan
- E13000Triple-negative oligometastatic breast cancer: A retrospective cohort.Jean Louis Lacaze, Bastien Cabarrou, Ciprian Chira, Thibaut Cassou Mounat et al.
- E12507Impact and prognosis of pembrolizumab combination in neoadjuvant chemotherapy for triple-negative breast cancer: A single-center retrospective study.Tomomi Fujisawa, Takeshi Miyamoto, Shoko Tokuda, Yasuhiro Yanagita et al.
- E13087Analysis of eligibility and reporting standards for older patients with hormone receptor–positive, HER2-negative metastatic breast cancer (HR+ MBC) in pivotal phase III clinical trials, 2015-2025.Sidharth Mahajan, Lawrence Nguyen, Jennifer Audrey Weiss, Gretchen Genevieve Kimmick
- E12718
- E12654Landscape of peripheral immune response induced by multimodal thermal therapy combined with chemoimmunotherapy in patients with early-stage HER2-negative breast cancer.Fei-Lin Qu, Zelu Zhang, Ke Wang, Yue Lou et al.
- E12659Net clinical value of neoadjuvant immune checkpoint inhibitors in early triple-negative breast cancer: Integrating efficacy heterogeneity and treatment burden.Luisana Sisca, Mariam Grazia Polito, Alessio Cortellini, Bruno Vincenzi et al.
- 1119The role of FOXM1 in regulating immune memory in triple-negative breast cancer and targeting FOXM1 to develop a therapeutic vaccine.Jian Huang, Virginia G. Kaklamani, Manjeet Rao, Nicolas Toshiaki Ryujin
- 1135Impact of protein–energy malnutrition on outcomes of metastatic triple-negative breast cancer patients receiving chemotherapy: A real-world analysis.Vaishali Deenadayalan, Vasanthan Muthusamy Kumarasamy, Kriti Ahuja, Malak Alharbi et al.
- E13031
- 562Predicting recurrence and survival in hormone receptor–positive (HR+)/HER2-negative (HER2–) early breast cancer (EBC) with machine learning models: Optimization of model complexity.Frederick Howard, Peter A. Fasching, Yeon Hee Park, Cesar Augusto Santa-Maria et al.
- E12527Risk stratification and age-related disparities with abemaciclib responses in early ER-positive/HER2-negative breast cancer.Masanori Oshi, Adrienne Groman, Takako Kuroda, Takuho Okamura et al.
- 570Evaluation of whole-exome and whole-genome sequencing tumor-informed circulating tumor DNA MRD assays in patients with early triple-negative breast cancer (TNBC) receiving neoadjuvant chemotherapy (NAC) with or without olaparib: A prospective sub-study of the PARTNER trial.Andrew Dooley, Rafaela S. Fontenele, Greg Grasse, Joanna Worley et al.
- E13026A HER2-targeted NIR-II fluorescent nanoprobe for precision diagnosis and treatment of HER2-positive breast cancer.Bing Liu, Shuzhao Chen, Jie Li, Yongqu Zhang
- TPS1161Evaluation of the safety and efficacy of TRC003 in metastatic triple-negative breast cancer: A prospective, open-label, multicenter, single-arm exploratory clinical trial.Xiaorong Sun, Yekuan Shi, Chuanbin Bian, Suping Li et al.
- 1134Immune infiltration features relative to cancer cell clumps as predictors of survival in triple-negative breast cancer.Himangi Srivastava, Jung Hun Oh, Leyla Ebrahimpour, James Mathews et al.
- 605Treatment patterns and oncologic outcomes in patients with triple-negative (TN) lobular breast cancer.Laura Burns Amin, Xiudong Lei, Lavinia P. Middleton, Kelly Hunt et al.
- E23328Antibody-drug conjugate adoption in triple-negative breast cancer through community-based quality improvement.Reshma L. Mahtani, Ilona Dewald, Samuel Dooyema, Clare Alexander et al.
- 1136Leveraging single-cell trajectory analysis and machine learning to build a robust prognostic classifier for triple-negative breast cancer to pinpoint CCDC171 as a master regulator.Jialiang Feng, Jiazhi Mi, Shijie Fang, Hui Yang
- E12504The efficacy of adjuvant chemoendocrine versus endocrine therapy alone in hormone receptor-positive, HER2-negative early breast cancer: A meta-analysis of reconstructed individual patient data.Khadija Mohib, Maaz Ahmad, Hira Shehzad, Arbab Khalid et al.
- 1087Oral estrogen receptor (ER) degraders compared to standard endocrine therapy (ET) in ER-positive, human epidermal growth factor receptor 2 (HER2)–negative metastatic breast cancer (MBC): A systematic review and meta-analysis.Hadar Goldvaser, Salome Khutsurauli, Michèle Buchinger, Anton Safonov et al.
- E14531Liquid biopsy with peripheral blood mononuclear cells: Deciphering systemic immunity to predict PARPi-immunotherapy efficacy in early HER2-negative breast cancer.Xiaying Kuang, Nan Shao, Runyi Ye, Yunjian Zhang et al.
- E12520Adjuvant immunotherapy following upfront surgery for stage II–III triple-negative breast cancer: A National Cancer Database Study.Madison T. Canning, Xiyuan (Angel) Ji, Lan Lei, Michael A. Schwartz et al.
- 1045Overall survival by genomic profile in HER2-positive (HER2+) metastatic breast cancer (mBC): A large US clinico-genomic database study.Paolo Tarantino, Xiaodan Mai, Jay Soh, Rani Bansal
- E23417Clinicopathologic features and survival outcomes of HER2-low versus HER2-negative (IHC 0) breast cancer in real-world practice.Maria Paula Uchima-Vera, Manuela Estrada, Maria Alejandra Gomez-Gutierrez, Mateo Barros et al.
- 2555Rab11 family interacting proteins as regulators of T cell recognition and infiltration in triple negative breast cancer.Paras R. Sahani, Kathleen Conway, Christopher Kywe, Saffet Guleryuz et al.
- E12647Anthracycline- and immunotherapy-free neoadjuvant chemotherapy versus KEYNOTE-522 regimen in early-stage triple-negative breast cancer.María Sánchez Esperilla, Iván Corriente Gordón, Maria Yeray Rodriguez Garcés, Maria Teresa Garrido Martínez et al.
- 1122AI-driven H&E plasma cell to predict pathological complete response in IO-treated triple-negative breast cancer (Yale; NCT02489448).Amritpal Singh, Arpit Aggarwal, Germán Corredor, Tilak Pathak et al.
- 1126Single cell spatial profiling for identification of organ-specific immune features in the peritumoral microenvironment of triple-negative breast cancer with liver metastases.Jin Sun Bitar, Shatakshi Shewale, David Lin, Yeonjoo Choi et al.
- E13122Antibody-drug conjugate plus immunotherapy versus chemotherapy-immunotherapy in PD-L1–positive metastatic triple-negative breast cancer: A trial-anchored analysis.Sri Pranita Cherukuri, Gowrishankar Palaniswamy, Prithvi Raghavan, Reshman Naga Kumar Jonnadula et al.
- 1127Trends in immunotherapy use and survival outcomes by metastatic pattern in metastatic triple-negative breast cancer.Michael Schwartz, Xiyuan (Angel) Ji, Jeffrey M. Switchenko, Madison T. Canning et al.
- E12630Real-world clinical outcomes of neoadjuvant pembrolizumab among patients with early-stage triple-negative breast cancer (esTNBC) in a US community oncology setting.Amin Mohammed Haiderali, Wilbur Pan, Michael A. Danso, Ila Sruti et al.
- E14009Intracranial activity of sacituzumab govitecan in HER2-negative breast cancer brain metastases: A systematic review and meta-analysis.Gabriela Gazzoni, Natalia Libonati, Isabella Michelon, Erika Bushatsky et al.
- E12605Analysis of the results of whole-exome sequencing of paired samples in patients of the Eurasian population with triple-negative breast cancer and their impact on clinical outcomes.Daria Bagdasarova, Irina Eremeeva, Maria Revkova, Egor Veselovsky et al.
- E12562AI-driven TILs spatial analysis to identify high-density hot spots as a superior prognostic marker in triple-negative breast cancer.Takuma Kobayashi, Kanako C. Hatanaka, Nobumoto Tomioka, Teppei Konishi et al.
- 1131Progression-free survival as a surrogate endpoint for overall survival in metastatic triple-negative breast cancer: A systematic review and meta-analysis.Yashasvi Srivastava, Shankar Biswas, Elangovan Krishnan, Rahul Falodia et al.
- TPS657
- 1030Association between HER family expression and clinical outcomes with trastuzumab deruxtecan (T-DXd) in patients with hormone receptor–positive/HER2-negative (HR+/HER2-) metastatic breast cancer (mBC).Shivani K. Thaker, Adam Dugan, Unnati Jariwala, Binyam Yilma et al.
- E24015Multi-center real-world validation of the HFA-ICOS cardio-oncology risk tool in HER2-positive breast cancer patients receiving anti-HER2 therapy.Lama Alfehaid, Ahmed Alanazi, Nada Alsuhebany, Khaled Alamer et al.
- 1059Dual HER2 blockade with or without taxane induction in HR+/HER2+ metastatic breast cancer: A comparative analysis of clinical outcomes.Mariah Black, Mostafa Eysha, Rafik ElBeblawy, Momo Arai et al.
- E12651Efficacy of neoadjuvant TCHP with primary empegfilgrastim (E) prophylaxis in HER2-positive early breast cancer (HER2+ eBC): Final results of the DEFENDOR SPECIAL study.Lyudmila Zhukova, Tansylu Ibragimova, Daria Filonenko, Inna Ganshina et al.
- 1120Rare histologic subtypes of triple-negative breast cancer: The impact of immunotherapy on outcomes for metastatic disease.Jincong Q. Freeman, Maeve Hennessy, Elizabeth Terman, Apoorva Ravichandran et al.
- E12523The effect of adjuvant carboplatin-based chemotherapy in stage I triple-negative breast cancer: A systematic review and meta-analysis of randomized controlled trials.Sharvani Alajpur, Kosuke Kawai, Kelly Elizabeth McCann, Nicholas Patrick McAndrew et al.
- 593Pathologic complete response in rare histologic subtypes of early-stage triple-negative breast cancer in the era of immunotherapy.Maeve Hennessy, Jincong Q. Freeman, Elizabeth Terman, Apoorva Ravichandran et al.
- E23345Survival, fertility preservation, and pregnancy after treatment in young patients with BRCA-associated triple-negative breast cancer.Akemi Kataoka, Meiko Nishimura, Ayumi Kanazawa, Mikiko Kai et al.
- E13131Treatment patterns and outcomes after metastatic recurrence following perioperative chemoimmunotherapy in triple-negative breast cancer (mTNBC).Riccardo Asnaghi, Carmine Valenza, Nadia Bianco, Monica Milano et al.
- E12649Partial breast irradiation followed by neoadjuvant immunochemotherapy in early TNBC.Sung Gwe Ahn, Seungho Baek, Soong June Bae, Yoonwon Kook et al.
- E12741Simultaneous anthracycline-based chemotherapy and dual HER2 blockade in early-stage HER2-positive breast cancer: A retrospective analysis.Miriam Emmelheinz, Daniel Uwe Reimer, Christine Brunner, Annette Reiner et al.
- E13033Efficacy and safety profiles of CDK4/6 inhibitor in patients with hormone receptor–positive and human epidermal growth factor receptor 2–negative (HR+/HER2−) advanced breast cancer (ABC) from the high-altitude versus low-altitude regions: A multi-center retrospective study.Yujing Tan, Yinyin Ye, Ying Fan, Binghe Xu et al.
- TPS1153ELEGANT: Elacestrant versus standard endocrine therapy (ET) in women and men with node-positive, estrogen receptor–positive (ER+), HER2-negative (HER2−), early breast cancer (eBC) with high risk of recurrence in a global, multicenter, randomized, open-label phase 3 study.Aditya Bardia, Virginia G. Kaklamani, Joyce O'Shaughnessy, Peter Schmid et al.
- 1054Neoadjuvant dalpiciclib combined with letrozole and dual HER2 blockade in HR+/HER2+ breast cancer: First-stage results of the HELEN HER2 017 trial.Jiujun Zhu, Zhenduo Lu, Junzhao Wu, Xuhui Guo et al.
- 502Efficacy and safety of giredestrant (GIRE) in patients (pts) with estrogen receptor–positive, HER2-negative early breast cancer (ER+, HER2– eBC) in the phase III lidERA BC clinical trial: Results by menopausal status.Peter Schmid, Charles E. Geyer, Miguel Martin, Sara A. Hurvitz et al.
- E13052Real-world treatment patterns and outcomes during and after treatment with CDK4/6 inhibitors for HR-positive and HER2-negative metastatic breast cancer.Shidi Zhao, Jiuda Zhao, Bin Song, Yingxia Tian et al.
- E12636A network meta-analysis of efficacy and safety of neoadjuvant anti-HER2 treatments in HER2-positive early breast cancer.Jianbin Li, Hanghang Ma, Feng Li, Fan Li et al.
- TPS1144A phase 1b/2 study of QLS1304, a novel, highly potent, and selective dual inhibitor of KAT6A/6B, plus endocrine therapy (ET) in patients (pts) with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2−) breast cancer (BC).Jiong Wu, Jian Zhang, Yongli Jin, Hongying Wei et al.
- E13040Efficacy of datopotamab deruxtecan after trastuzumab deruxtecan in metastatic hormone receptor–positive HER2-negative breast cancer: A real-world study.Yosuke Aoyama, Yukinori Ozaki, Masahiro Kuno, Emi Taniguchi et al.
- 3071Multicenter clinical study of [ 18 F]AlF-HER2-BCH PET/CT as a molecular pathology tool for linear quantification of HER2 expression levels in breast cancer.Xiaoyi Guo, Xu Liang, Hua Zhu, Guohong Song et al.
- E13043Efficacy and safety of AKT inhibitor NTQ1062 combined with fulvestrant in patients with HR-positive/HER2-negative metastatic breast cancer:a proof-of-concept, multicenter, open-label, nonrandomized, phase Ib/II study.Yanchun Meng, Jian Zhang, Yongmei Yin, Yueyin Pan et al.
- 1076Efficacy and safety of SPH4336 plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer with brain metastases: A multicenter, single-arm, phase II study.Kuikui Jiang, Shusen Wang, Qingyuan Zhang, Jing Sun et al.
- E12594Examining the tumor microbiology and microenvironment of patients with triple-negative inflammatory breast cancer receiving KEYNOTE-522.Azadeh Nasrazadani, Bora Lim, Angela Alexander, Bisrat G. Debeb et al.
- 531Chemotherapy (CT) use by Oncotype DX (O-Dx) recurrence score (RS) in hormone receptor–positive, HER2-negative (HR+/HER2-) invasive lobular carcinoma (ILC): A contemporary National Cancer Database (NCDB) analysis.Marija Sullivan, Xiudong Lei, Inimfon Jackson, Jason A. Mouabbi et al.
- E12727Treatment response and clinical outcomes of patients with triple negative invasive apocrine breast carcinoma.Courtnie Brown, Paige Brown, Alexis Ann LeVee, Marla Lipsyc-Sharf et al.
- E12503Adjuvant trastuzumab with or without pertuzumab after pathologic complete response to neoadjuvant HER2-targeted therapy and chemotherapy in HER2-positive breast cancer: A retrospective cohort study.James Fradin, Amber Haugen, Yushan Yang, Adam Kidwell et al.
- E13109Safety and 5-year survival following treatment with leronlimab plus physician’s choice combination therapy in patients with metastatic triple-negative breast cancer.Debasish Tripathy, Milana V. Dolezal, Vandana G. Abramson, Namita Chittoria et al.
- 617Structural determinants compared with genetic ancestry and self-reported race in triple-negative breast cancer disparities: A multilevel analysis in an admixed population.Patrick De Cerqueira, Rafael Canfield Brianese, André Luiz Cicilini, Solange Moraes Sanches et al.
- E12638Real-world efficacy and safety of neoadjuvant pembrolizumab in early-stage triple-negative breast cancer: A systematic review and meta-analysis.Yousef Joseph, Saad Arsalan Wasti, Saima Gill, Alina Jamshed et al.
- 594Association of immunotherapy infusion timing with outcomes in early-stage triple-negative breast cancer.Xianghui Zou, Yashran Islam, Victoria Lam, Vicky Ma et al.
- E13061Oral selective estrogen receptor degrader monotherapy versus standard endocrine therapy in estrogen receptor-positive, HER2-negative advanced breast cancer with ESR1 mutations: A meta-analysis of randomized trials.Zainab Sabir, Mirza Muhammad Hadeed Khawar, Sarjana Singh, Asmaa Abu Obaid et al.
- TPS1149HERTHENA-Breast04: A phase 3, randomized, open-label study evaluating the efficacy and safety of patritumab deruxtecan (HER3-DXd) versus treatment of physician’s choice in hormone receptor–positive (HR+)/human epidermal growth factor receptor 2–negative (HER2−) unresectable locally advanced or metastatic breast cancer.Barbara Pistilli, Surui Hou, Julie Marie Collins, Preeti Khetarpal Sudheendra et al.
- TPS1150Camizestrant plus ribociclib in hormone receptor–positive/HER2-negative advanced breast cancer: The phase II CADILLAC trial.Javier Cortes, Angel Guerrero-Zotano, Maria Gion, Cristina Alba Torres et al.
- 560Prognostic value of an MRI-derived recurrence assay in women with hormone receptor–positive, HER2-negative breast cancer: A retrospective, multi-center analysis.Matthew P. Goetz, Qinmei Xu, Vincent Reid, Hari Trivedi et al.
- E12590Genomic and clinical characterization of estrogen receptor–positive/HER2-negative early breast cancer: Results from the NextGIM study.Chiara Molinelli, Barbara Cardinali, Benedetta Conte, Marco Bruzzone et al.
- TPS1143A phase II study evaluating treatment discontinuation of dual anti-HER2 therapy in metastatic HER2-positive breast cancer after five years of sustained complete response (FREEDOME-trial).Albert Grinshpun, Amir Sonnenblick, Yasmin Leshem, Salome Khutsurauli et al.
- 1016Post-progression treatment (tx) analyses of evERA Breast Cancer (BC): A phase III trial of giredestrant (GIRE) + everolimus (E) in patients (pts) with estrogen receptor–positive, HER2-negative advanced BC (ER+, HER2– aBC) previously treated with a CDK4/6 inhibitor (i).Komal L. Jhaveri, Hope S. Rugo, Sara M. Tolaney, Miguel Martin et al.
- LBA1006Giredestrant (GIRE) + palbociclib (PALBO) vs letrozole (LET) + PALBO as first-line (1L) therapy in patients (pts) with estrogen receptor–positive, HER2-negative locally advanced or metastatic breast cancer (ER+, HER2– LA/mBC): Primary analysis of the phase III persevERA BC trial.Nicholas C. Turner, Komal L. Jhaveri, Aditya Bardia, Naoki Niikura et al.
- 529Platinum-based chemotherapy in early-stage, high-risk, triple-negative breast cancer: A systematic review and meta-analysis of randomized trials.Jesse Lopes da Silva, Mariana Carvalho Gouveia, Anelise Poluboiarinov Cappellaro, Mariana Macambira Noronha et al.
- E13120Real-world outcomes of first-line pembrolizumab plus chemotherapy in metastatic triple-negative breast cancer with central nervous system metastases: A multicenter cohort from Poland, the Czech Republic, and Slovakia.Malgorzata Pieniazek, Milos Holanek, Katarzyna Świderska, Bartosz Gasior et al.
- TPS2698A phase II study of the DNA plasmid-based vaccine STEMVAC in patients with metastatic triple-negative breast cancer (mTNBC).Brie Chun, Natasha Hunter, William R. Gwin, Andrew L. Coveler et al.
- E13119Treatment outcomes with pembrolizumab and chemotherapy in metastatic metaplastic triple-negative breast cancer: Data from a central European cohort.Justyna Żubrowska, Malgorzata Podskarbi, Aleksandra Konieczna, Magdalena Szymanik-Resko et al.
- 1079Outcomes by lobular (lob) histology status at initial diagnosis in patients (pts) in the INAVO120 phase 3 trial with PIK3CA -mutated (mut), hormone receptor-positive (HR+), HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC) treated with inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV).Nicholas C. Turner, Kevin Kalinsky, Katherine E. Hutchinson, Yanling Jin et al.
- E13507Designing a triple-negative breast cancer patient journey: A multi-stakeholder initiative to improve clinical pathways and communication in Italy.Nicla Maria La Verde, Luisa Brogonzoli, Adele Sgarella, Laura Cortesi et al.
- 616
- E13058Clinical benefit of oral selective estrogen receptor degraders in ESR1 -mutant, HR-positive, HER2-negative advanced breast cancer: A systematic review and meta-analysis.Natalia Nunes, Lorrany Larisse Costa Rodrigues, Lara De Holanda Jucá Silveira, Luiz F. Costa De Almeida et al.
- E15046
- 1019Paclitaxel plus bevacizumab with or without atezolizumab for hormone receptor-positive/HER2-negative advanced breast cancer: JCOG1919E (AMBITION) phase III trial.Fumikata Hara, Kan Yonemori, Makiko Ono, Takayuki Ueno et al.
- E12529Real-world analysis of adjuvant abemaciclib in high-risk HR+/HER2− early breast cancer.Mariam Haji, Zunairah Shah, Han Yu, Sheheryar Kairas Kabraji
- 1046
- 1078BL0175, a novel nano-mediated polypeptide conjugate of protein degrader, in patients (pts) with locally advanced/metastatic HR+/HER2− breast cancer (HR+, HER2- LA/mBC): Initial results from a phase 1 study.Nanya Wang, Songling Zhang, Meili Sun, Qing Wen et al.
- 1020Impact of bevacizumab on the efficacy of antibody–drug conjugates as later-line treatment of basal-like immune-suppressed triple-negative breast cancer.Yin Liu, Fan Yang, Wenjia Zuo, Xi-Yu Liu et al.
- TPS644ASPRIA: A single-arm phase 2 trial of atezolizumab with sacituzumab govitecan to prevent recurrence in triple-negative breast cancer.Payal Deepak Shah, Angela DeMichele, Paul Wileyto, Sara M. Tolaney et al.
- E13108Baseline inflammatory indexes and prognosis for progression-free survival in first-line pembrolizumab plus chemotherapy for PD-L1-positive advanced triple-negative breast cancer: A Polish multicenter cohort study.Malgorzata Pieniazek, Karolina Winsko-Szczęsnowicz, Aleksandra Konieczna, Iwona Danielewicz et al.
- E12577Impact of neutrophil-to-lymphocyte ratio on pathological response in HER2-positive breast cancer patients: A retrospective analysis.Namra Naseer, Ayesha Syed, Naqeeb Ullah
- E13047Efficacy and toxicity of CDK4/6 inhibitors in early and metastatic HR+/HER2– breast cancer.Ravneet Kaur Dhanoa, Sumin Thapa, Pragnan Kancharla, Shweta Kurian
- E13121Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in triple-negative breast cancer: A systematic review and meta-analysis.Haseeb Tareen, Allah Dad, Muhammad Arham, Haris Bin Tahir et al.
- E13044(RW) post-progression outcomes after first-line (1L) treatment with ribociclib + an aromatase inhibitor (AI) vs AI alone in US patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (MBC).Lowell L. Hart, Hope S. Rugo, VK Gadi, Priyanka Sharma et al.
- E12530Survival outcomes of high and intermediate-risk hormone receptor (HR)-positive human epidermal growth receptor-2 (HER2)-negative early breast cancer patients (EBC) who did and did not receive (neo)adjuvant chemotherapy.Winnie Yeo, Lok-Wa Yuen, Ting Ying Ng, Inda Sung Soong et al.
- 1053Intracranial efficacy and safety of trastuzumab deruxtecan in HER2-positive and HER2-low metastatic breast cancer with central nervous system involvement: A systematic review and proportional meta-analysis.Dua Azim, Sohail Kumar, Mesum Abbas, Muhammad Moin Ud Din Arshad et al.
- E12673Survival outcomes of neoadjuvant versus adjuvant chemotherapy in stage II-III hormone receptor-positive/HER2-negative breast cancer: A propensity score–matched analysis.Armando Orlandi, Francesca Salvatori, Lucia Sacco, Giorgia Arcuri et al.
- E15070Development of an [18F]-labeled glutamine PET radiotracer to detect serine synthesis pathway activity in HER2-positive breast cancer.Darshi N. Shah, Veer Shah, Jules A. Cohen
- 595Neoadjuvant chemotherapy combined with toripalimab for triple-negative breast cancer: A prospective, single-arm, multi-center study (NEOTORCH-BREAST02).Zhijun Dai, Guansheng Zhong, Ying Chen, Minya Yao et al.
- 600Neoadjuvant penpulimab combined with taxanes and carboplatin in triple-negative breast cancer: Updated efficacy and safety results from the phase II NeoTAPPL study.Guozhi Zhang, Wenting Yan, Long Yuan, Jing Liu et al.
- E13111Prognostic value of baseline 18F-FDG PET/CT in first-line pembrolizumab plus chemotherapy for metastatic triple-negative breast cancer.Marcin Kubeczko, Miroslawa Puskulluoglu, Milos Holanek, Dana Dvorakova et al.
- E13112Radiotherapy in symptomatic metastatic triple-negative breast cancer treated with first-line pembrolizumab and chemotherapy: A multinational real-world study.Marcin Kubeczko, Miroslawa Puskulluoglu, Milos Holanek, Malgorzata Meluch et al.
- 1084Impact of oral SERDs, including giredestrant, on survival in HR+ HER2− metastatic breast cancer: A meta-analysis.Changtai Tian, Alison Stopeck, Harry Fruchtman, Anna Andrzejczyk
- 1058HER2-targeted tyrosine kinase inhibitors in breast cancer: Real-world analysis of gastrointestinal and musculoskeletal toxicities using the FAERS database.Sneha Singh, Shivani Modi, Dawood Findakly
- E13003Clinical outcomes of heart failure in breast cancer patients receiving HER2-directed therapy: A retrospective analysis (2016–2020).Rabia Iqbal, Ahmad Taimoor Bajwa, Amina Jafar, Madhulika Urella
- 1055Safety and efficacy of ZN-A-1041, a highly blood-brain barrier (BBB)–permeable HER2 tyrosine kinase inhibitor (TKI), + trastuzumab deruxtecan (T-DXd) or pertuzumab-trastuzumab (PH) in HER2-positive metastatic breast cancer (HER2+ mBC): Phase Ic expansion results from the ZN-A-1041-101-US trial.Nancy U. Lin, Sarah Heeson, Mahesh Shivhare, Ziqiang (Zack) Cheng et al.
- LBA514Neoadjuvant rilvegostomig (R) + trastuzumab deruxtecan (T-DXd) in high-risk HER2-negative breast cancer: Results from the I-SPY 2.2 trial.Ciara Catherine O'Sullivan, Kevin Kalinsky, Christina Yau, Anne M. Wallace et al.
- TPS1145TUC-TOC phase II trial (NCT05955170): Tucatinib in combination with oral etoposide (VP16) and trastuzumab in patients with metastatic HER2-positive breast cancer (HER2+ mBC).Diana Bello Roufai, Alexia Savignoni, Frederique Berger, Aurelie Moreira et al.
- E13059Tumor immune microenvironment of metastatic HR+ HER2- breast cancer treated with CDK4/6 inhibitors.Brie Chun, Cameron Watson, Allison Creason, Andy Kaempf et al.
- E12518Patient preferences for duration of adjuvant trastuzumab for HER2+ breast cancer.Helena Margaret Earl, Liam J. Schmitt, Monica Peek, Mark J. Ratain et al.
- E13039Real-world effectiveness of CDK4/6 inhibitor re-treatment in HR+/HER2- metastatic breast cancer.Xi Liang, David D. Stenehjem, Xiangyang Ye, Eleni Maria Gamvroulas et al.
- 1086An early resistance genomic state (ERGS) as an identifier of primary CDK4/6 inhibitor failure in HR+/HER2− metastatic breast cancer.Mobina Shrestha, Salina Dahal, Vishal Mandal
- E24206Interstitial lung disease risk and outcomes across HER2-targeted therapies commonly used in breast cancer: Analysis of real-world FAERS data.Sneha Singh, Anubhuti Sharma, Sangam Sangam, Dawood Findakly
- E13020Sequential use of antibody-drug conjugates in advanced breast cancer: A real-world study based on HER2 status.Gang Li, Qing Qu, W Zhu, Hongwei Zhang et al.
- E13118Real-world survival outcomes with pembrolizumab plus chemotherapy in advanced triple-negative breast cancer: Multicenter evidence from Poland, the Czech Republic, and Slovakia.Miroslawa Puskulluoglu, Joanna Kiszka, Aleksandra Konieczna, Milos Holanek et al.
- E13024
- 1009Efficacy and safety of camrelizumab combined with docetaxel and carboplatin as neoadjuvant therapy for triple-negative breast cancer: The HELEN-Trio 011 randomized clinical trial.Zhenzhen Liu, Dechuang Jiao, Xianfu Sun, Jianghua Qiao et al.
- 1124Real-world effectiveness and safety of first-line pembrolizumab plus chemotherapy in patients aged ≥65 years with metastatic triple-negative breast cancer.Aleksandra Konieczna, Malgorzata Meluch, Milos Holanek, Zuzana Bielčiková et al.
- E12760Patterns of failure and outcomes in triple-negative compared to estrogen receptor–positive breast cancer.Tanun Jitwatcharakomol, Yevgeniya Gokun, Jacob Eckstein, Therese Andraos et al.
- 2588Multi-omics analysis from the IMMUcan consortium to identify predictors of chemo-immunotherapy response in early-stage triple-negative breast cancer.Andrea Joaquin Garcia, Marcela Carausu, Mattia Rediti, Marie Morfouace et al.
- TPS1163A randomized phase II study of pembrolizumab plus paclitaxel with or without bevacizumab in PD-L1–positive recurrent triple-negative breast cancer previously treated with perioperative immune checkpoint inhibitors: WJOG16522B (PRELUDE) trial.Kazuki Nozawa, Yukinori Ozaki, Tomohiro Oshino, Kaori Terata et al.
- TPS643Precision DC: Personalized neoantigen dendritic cell vaccine pilot trial for high-risk triple-negative breast cancer after neoadjuvant therapy.Hatem Hussein Soliman, Aixa Elena Soyano Muller, Ricardo L. Costa, Hyo S. Han et al.
- 536A randomized phase II trial of folate receptor alpha peptide vaccine in early-stage triple-negative breast cancer.Keith L. Knutson, David W. Hillman, Davitte Cogen, Alvaro Moreno-Aspitia et al.
- 607Health-related quality of life with low-dose pembrolizumab plus chemotherapy in early triple-negative breast cancer: Findings from the PLANeT trial.Adhip Arora, Hemavathi Baskarane, Ghazal Tansir, Sameer Bakhshi et al.
- E12635Pre-operative intratumoral toll-like receptor 9 (TLR9) agonist vidutolimod (Vidu) and stereotactic body radiation therapy (SBRT) in early triple-negative breast cancer (eTNBC): Randomized phase 2 CyberImmunoBreast trial.Khalil Zaman, Stephanie Tissot, Estelle Dubruc, Ourania Dafni et al.
- 1544Time to treatment initiation for triple-negative breast cancer in Brazil: A call for public health action.Fernanda Madasi Pinheiro, Renata Colombo Bonadio, Wesley Antônio Lopes de Lima, Andre Joao Rossi et al.
- 611DCE-MRI for assessment of pathologic complete response after completion of neoadjuvant therapy in triple-negative breast cancer patients.Xiaofei Huo, Tanya W. Moseley, Beatriz Adrada, Clinton Yam et al.
- E13125Treatment-emergent thyroid disorders and outcomes of first-line pembrolizumab plus chemotherapy in metastatic triple-negative breast cancer: A real-world study.Malgorzata Podskarbi, Aleksandra Konieczna, Milos Holanek, Katarzyna Świderska et al.
- E16035Liposomal irinotecan plus sintilimab and lenvatinib for second-line advanced HER2-negative gastric/gastro-esophageal junction adenocarcinoma: A phase II trial.Yangwei Fan, Xuyuan Dong, Meichen Wang, Yu Shi et al.
- 598
- 1077[ 18 F] Fluoroestradiol PET/CT to guide second-line treatment decision-making in patients with estrogen receptor–positive, HER2-negative advanced breast cancer after progression on first-line aromatase inhibitor and CDK4/6 inhibitor: Primary results of ESTROTIMP.Francois Clement Bidard, Romain-David Seban, Stephanie M. van de Ven, Sylvain Ladoire et al.
- 625Neoadjuvant DAN-222 plus niraparib in high-risk HER2-negative breast cancer: Results from the I-SPY 2 adaptive platform trial.Kay T. Yeung, Claudine Isaacs, Marissa Howard-Mcnatt, Christina Yau et al.
- E12609Clinical and molecular features of patients with PIK3CA -mutant ( PIK3CA m) ER+/HER2− breast cancer with detectable circulating tumor DNA (ctDNA) in early breast cancer (eBC).Niharika Duggirala, Sandro Satta, Bhakti Dwivedi, Philip Miller et al.
- 1073(RW) post-progression outcomes following first-line (1L) ribociclib (RIB) + aromatase inhibitor (AI) versus AI alone in African American and low socio-economic status (SES) patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2–) metastatic breast cancer (MBC) in US.VK Gadi, Lowell L. Hart, Paolo Tarantino, Priyanka Sharma et al.
- E23402Recurrence patterns and survival in hormone receptor-positive/HER2-negative early breast cancer: A retrospective analysis from a public oncologic institution in Peru.Guillermo Valencia, Alexandra Saavedra, Zaida Morante, Patricia Rioja et al.
- LBA1018Palbociclib plus tamoxifen ± goserelin in women with hormone receptor (HR)-positive, HER2-negative advanced breast cancer (BC): PATHWAY, an Asian international double-blind randomized phase 3 trial—Final overall survival (OS) analysis.Yen-Shen Lu, Emi Noguchi, Takashi Yamanaka, Hirofumi Mukai et al.
- 1067Vepdegestrant, a proteolysis targeting chimera (PROTAC) estrogen receptor (ER) degrader, plus abemaciclib (ABE) in ER+/human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer (ABC): TACTIVE-U phase 1b/2 results.Rachel M. Layman, Katarzyna Joanna Jerzak, John Frederick Hilton, Pablo Tolosa Ortega et al.
- 1052Molecular imaging as a tool to predict patient outcomes in advanced HER2-low breast cancer on trastuzumab deruxtecan (T-DXd): The FHERAD trial.Xiaoyi xiaoyi Guo, Xu Liang, Hua Zhu
- TPS1146HER2-positive central nervous system (CNS) surveillance: A study of the feasibility of randomizing women and men with HER2-positive metastatic breast cancer to CNS surveillance versus no surveillance.Talvinder Bhogal, Sara Jayne Meade, Ciara O'Brien, Annabel Borley et al.
- TPS1165Phase IIa, open-label, multi-center study of the DNA polymerase theta inhibitor ART6043 administered orally in combination with olaparib to patients with HER2-negative breast cancer with a germline BRCA1/2 mutation (randomized expansion of study NCT05898399).Mark Robson, Timothy A. Yap, Gaorav P. Gupta, Raquel Andrés et al.
- E12668Comparative efficacy and safety of anti-HER2 neoadjuvant therapy in early-stage HER2-positive breast cancer: A real-world multicenter analysis.Yuqin Zhou, Juncheng Xuhong, Ya Wei, Maoshan Chen et al.
- 1123JSKN016, a first-in-class anti-TROP2/HER3 bispecific antibody-drug conjugate (ADC), in patients (pts) with HER2-negative locally advanced or metastatic breast cancer: Results from a phase I study.Herui Yao, Zhangzhou Huang, Hong Zong, Min Yan et al.