Neuroblastoma
High-risk and relapsed disease: MYCN amplification, ALK mutations and anti-GD2 therapy.
Registry changes (new trials, status, phase, endpoint and readout-date changes, results) come from the OncoSignal store, last verified against ClinicalTrials.gov 2026-11-11 08:26 UTC.
- PaperFeasibility and Tolerability of Chemoimmunotherapy Given During Induction for Treatment of Patients With High-Risk Neuroblastoma: A Report From the Children's Oncology Group.
Federico SM, Naranjo A, Zhang FF et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
- Paper
- Results postedResults posted: NCT03033303
A Study of the Effect of Hu3F8/GM-CSF Immunotherapy Plus Isotretinoin in Patients in First Remission of High-Risk Neuroblastoma
- PaperCirculating Biomarkers of Disease Burden in Patients With Relapsed or Refractory Neuroblastoma Treated With (131)I-MIBG Therapy: A Report From the New Approaches to Neuroblastoma Therapy Consortium.
Campbell K, Klega K, Marachelian A et al. Pediatric blood & cancer.
- New trialNew Ph1 trial: GD2CART-BEV (NCT07897968)
Universität Münster. GD2IL18CART Combined With Bevacizumab for Relapsed and Refractory GD2-positive Solid Tumors
- PaperEfficacy and Safety of Alectinib in Pediatric and Adult Patients with ALK-Altered Advanced Solid Tumors: a phase II TACKLE Trial (NCCH1712/MK003).
Okuma HS, Arakawa A, Hirakawa A et al. Clinical cancer research : an official journal of the American Association for Cancer Research.
- Readout dueReadout due: NCT05642455 reached primary completion
USWM CT, LLC. SPEARHEAD-3 Pediatric Study
- Readout dueReadout due: NCT02176967 reached primary completion
Children's Oncology Group. Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
- Readout dueReadout due: NCT00911560 reached primary completion
Memorial Sloan Kettering Cancer Center. Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma
- Readout dueReadout due: NCT04724369 reached primary completion
Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC). Open-Label Study of 18F-mFBG for Imaging Neuroblastoma
A phase advance is an asset's first trial at a higher phase than any earlier trial of the same asset in this indication. Readout due means the registry's primary completion date has passed; it is not a disclosure.