Clinical Trials

Trials

Studies that name Clinical Trials as principal investigator, study chair or study director, newest first. Live from ClinicalTrials.gov, fetched 2026-11-11 19:45 UTC. Showing 200 of 6392. Open this list on ClinicalTrials.gov

• Ph3
  NCT07918846 · A Clinical Study Testing Enicepatide in Participants Living With Overweight or Obesity and Cardiovascular Disease

  Hoffmann-La Roche · not yet recruiting · Overweight, Obesity, Cardiovascular Disease · study director
• Ph4
  NCT07908459 · B-Ensure: Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants

  GlaxoSmithKline · not yet recruiting · Hepatitis B · study director
• Ph1
  NCT07905924 · A Study to Evaluate the Safety and Effectiveness of Different Doses of RO7836748 Alone or in Combination With Other Cancer Therapies in People With Solid Tumors With a Rat Sarcoma Viral Oncogene Homolog Glycine 12 Valine (RAS G12V) Mutation

  Hoffmann-La Roche · not yet recruiting · Solid Tumors · study director
• Ph1
  NCT07905157 · A Study to Compare Blood Levels of Bepirovirsen and Safety Using Different Methods of Injecting in Healthy Adult Participants

  GlaxoSmithKline · not yet recruiting · Hepatitis B · study director
• Ph3
  NCT07889648 · A Clinical Study to Evaluate the Effects of Enicepatide Versus Tirzepatide in Participants With Type 2 Diabetes and Inadequate Blood Sugar Control on Oral Glucose-Lowering Medications

  Hoffmann-La Roche · not yet recruiting · Type 2 Diabetes Mellitus · study director
• Ph1
  NCT07883577 · A Study of RO7821657 in Participants With Solid Tumors

  Hoffmann-La Roche · not yet recruiting · Locally Advanced or Metastatic Solid Tumors · study director
• Ph1
  NCT07867171 · A Study to Investigate the Effects of Moderate or Severe Renal Impairment (RI) on Velzatinib

  GlaxoSmithKline · not yet recruiting · Healthy Participants, Gastrointestinal Neoplasms · study director
• Ph1
  NCT07867262 · A Study to Evaluate the Effects of GDC-4198 in Combination With Letrozole, Fulvestrant, or Giredestrant in Participants With Locally Advanced or Metastatic Hormone Receptor-Positive, HER2-Negatve Breast Cancer

  Genentech, Inc. · not yet recruiting · Advanced or Metastatic Breast Cancer · study director
• Ph1
  NCT07862114 · A Study to Investigate the Effect of Omeprazole and Cyclosporine on Velzatinib in Healthy Participants

  GlaxoSmithKline · not yet recruiting · Healthy Participants, Gastrointestinal Neoplasms · study director
• Ph3
  NCT07860450 · Two Part (Phase1b/ Phase3) Trial of Subcutaneous Dostarlimab Plus Carboplatin-Paclitaxel in Participants With Primary Advanced or Recurrent Endometrial Cancer

  GlaxoSmithKline · not yet recruiting · Endometrial Carcinoma, Neoplasms, Endometrial · study director
• Ph1
  NCT07859735 · A Study to Investigate the Effects of Impaired Hepatic Function on Velzatinib

  GlaxoSmithKline · not yet recruiting · Healthy Participants, Gastrointestinal Neoplasms · study director
• Ph1
  NCT07859085 · A Study to Evaluate the Safety and Activity of GDC-7035 With Anti-Cancer Therapies in Participants With KRAS G12D-Mutated Unresectable Advanced or Metastatic Colorectal Cancer or Pancreatic Ductal Adenocarcinoma

  Genentech, Inc. · not yet recruiting · Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma · study director
• N/A
  NCT07850141 · Prospective Registry of Exposure to Gepotidacin (PREG)

  GlaxoSmithKline · not yet recruiting · Sexually Transmitted Diseases · study director
• Ph3
  NCT07846683 · A Study to Assess the Efficacy and Safety of Subcutaneous Induction Therapy With Afimkibart in Participants With Moderately to Severely Active Ulcerative Colitis

  Hoffmann-La Roche · recruiting · Moderately to Severely Active Ulcerative Colitis · study director
• Ph3
  NCT07838194 · Clinical Trial of NXT007 for the Prophylactic Treatment of Hemophilia A in Infants and Children

  Hoffmann-La Roche · not yet recruiting · Hemophilia A · study director
• Ph1
  NCT07835243 · A Study to Assess the Effect of Subcutaneous Injection Site on the Pharmacokinetics of Pegozafermin in Healthy Participants

  Hoffmann-La Roche · not yet recruiting · Healthy Volunteers · study director
• N/A
  NCT07827586 · Non-interventional Study of Subcutaneous Ocrelizumab in Persons With Relapsing-Remitting Multiple Sclerosis

  Hoffmann-La Roche · recruiting · Relapsing-Remitting Multiple Sclerosis · study director
• Ph3
  NCT07827573 · A Study to Learn How Well Participants With a Specific Type of Early Breast Cancer (ER-Positive, HER2-Negative) Tolerate and Stay on Treatment With Giredestrant and How They Feel During Treatment

  Hoffmann-La Roche · recruiting · Early Breast Cancer, Estrogen Receptor-Positive Breast Cancer, HER2-Negative Breast Cancer · study director
• Ph3
  NCT07827599 · A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants

  Hoffmann-La Roche · recruiting · Influenza, Human, Respiratory Tract Infections, Post-exposure Prophylaxis · study director
• Ph2
  NCT07825064 · Cevostamab in Combination With Pomalidomide and Dexamethasone After BCMA- Targeting CAR T-Cell Therapy in Participants With Previously Treated Multiple Myeloma

  Hoffmann-La Roche · recruiting · Multiple Myeloma · study director
• Ph1/Ph2
  NCT07822334 · A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease

  Hoffmann-La Roche · recruiting · Chronic Obstructive Pulmonary Disease (COPD), Healthy Participants · study director
• Ph3
  NCT07807969 · An Open-label Extension Study of the Long-Term Safety of Vonaprument (ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)

  Annexon, Inc. · not yet recruiting · Geographic Atrophy · study director
• Ph1
  NCT07797478 · A Study of RO7890597 in Healthy Adult Volunteers

  Genentech, Inc. · recruiting · Healthy Volunteers · study director
• Ph1
  NCT07789899 · A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Two GSK3862995B Formulations in Healthy Participants

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph2
  NCT07791043 · A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)

  GlaxoSmithKline · recruiting · Liver Diseases, Alcoholic · study director
• Ph3
  NCT07782970 · A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

  GlaxoSmithKline · recruiting · Nasal Polyps · study director
• Ph3
  NCT07782957 · A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

  GlaxoSmithKline · recruiting · Nasal Polyps · study director
• Ph3
  NCT07782996 · A Study to Investigate the Efficacy and Safety of GSK5784283 Compared With Placebo in Participants With Uncontrolled Asthma (PERSIST ASTHMA-2)

  GlaxoSmithKline · recruiting · Asthma · study director
• Ph2
  NCT07781644 · Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease

  Hoffmann-La Roche · recruiting · Parkinson's Disease · study director
• Ph2
  NCT07781657 · Study to Test Effects and Safety of RO7568282 in Early Symptomatic Alzheimer's Disease

  Hoffmann-La Roche · recruiting · Alzheimer's Disease · study director
• Ph3
  NCT07778667 · A Study to Learn How Well Lucerastat Works and How Safe it is in Untreated Adult Male Participants With Fabry Disease

  Idorsia Pharmaceuticals Ltd. · recruiting · Fabry Disease · study director
• Ph3
  NCT07780669 · A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-1)

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph3
  NCT07780643 · A Study to Investigate the Efficacy and Safety of GSK5784283 Compared With Placebo in Participants With Uncontrolled Asthma (PERSIST ASTHMA-1)

  GlaxoSmithKline · recruiting · Asthma · study director
• Ph3
  NCT07780656 · A Study to Investigate the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Moderate to Very Severe COPD (PERSIST COPD-2)

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph1
  NCT07749157 · A Study of Subcutaneously Administered RO7845860 in Participants With Relapsing Multiple Sclerosis

  Hoffmann-La Roche · not yet recruiting · Relapsing Multiple Sclerosis · study director
• Ph1
  NCT07747480 · A Sub Study to Investigate the Safety and Tolerability of Aletekitug in Participants With Moderate To Severe Ulcerative Colitis

  GlaxoSmithKline · recruiting · Colitis, Ulcerative · study director
• Ph1
  NCT07747467 · A Study to Investigate the Safety and Tolerability of Multiple Study Interventions in Participants With Moderate to Severe Ulcerative Colitis

  GlaxoSmithKline · recruiting · Colitis, Ulcerative · study director
• Ph2
  NCT07748208 · A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes

  Hoffmann-La Roche · recruiting · Breast Cancer, Diabetes Type II · study director
• Ph1
  NCT07741604 · A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions

  Hoffmann-La Roche · recruiting · Renal Impairment · study director
• Ph2
  NCT07721025 · Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy

  Lexeo Therapeutics · recruiting · Friedreich Ataxia, Cardiomyopathy, Secondary · study director
• Ph3
  NCT07717411 · A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

  Hoffmann-La Roche · recruiting · Alzheimer's Disease · study director
• Ph1
  NCT07712393 · A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283

  GlaxoSmithKline · active not recruiting · Asthma · study director
• Ph3
  NCT07704892 · A Study to Investigate Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)

  GlaxoSmithKline · recruiting · Metabolic Dysfunction-associated Steatohepatitis · study director
• Ph3
  NCT07701993 · A Pivotal Clinical Study to Investigate the Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)

  GlaxoSmithKline · recruiting · Metabolic Dysfunction-associated Steatohepatitis · study director
• Ph4
  NCT07701967 · Efficacy and Safety of Depemokimab Monotherapy Without Concomitant Use of Intranasal Corticosteroids (INCS) in Japanese Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

  GlaxoSmithKline · recruiting · Nasal Polyps · study director
• Ph1
  NCT07684586 · A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation Prototypes

  GlaxoSmithKline · withdrawn · Cough · study director
• Ph2
  NCT07682129 · Long-Term Extension Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon Skipping to Evaluate the Safety and Efficacy of Endosomal Escape Vehicle Phosphorodiamidate Morpholino Oligomer Platform Products (ELEVATE-LTE)

  Entrada Therapeutics, Inc. · not yet recruiting · Duchenne Muscular Dystrophy (DMD) · study director
• Ph3
  NCT07670416 · A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes

  Hoffmann-La Roche · recruiting · Obesity, Overweight, Type 2 Diabetes Mellitus (T2DM) · study director
• Ph3
  NCT07671001 · A Study of Depemokimab in Participants of 6 to 11 Years of Age

  GlaxoSmithKline · recruiting · Asthma · study director
• Ph1
  NCT07667322 · A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis

  Hoffmann-La Roche · active not recruiting · Multiple Sclerosis · study director
• Ph2
  NCT07667569 · A Study to Learn How Safe ACT-777991 is and How Well it Works in Adults With Non-segmental Vitiligo

  Idorsia Pharmaceuticals Ltd. · recruiting · Non-Segmental Vitiligo · study director
• Ph1
  NCT07665723 · An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis

  Hoffmann-La Roche · recruiting · Active Ulcerative Colitis · study director
• Ph4
  NCT07652515 · A Study to Evaluate the Safety of Dostarlimab in Adult Participants in India With Primary Advanced or Recurrent Endometrial Cancer

  GlaxoSmithKline · not yet recruiting · Neoplasms, Endometrial · study director
• Ph3
  NCT07650084 · A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension

  GlaxoSmithKline · recruiting · Refractory Chronic Cough · study director
• Ph3
  NCT07645248 · A Study to Compare Safety of 4 Weeks Exposure to Propellants Hydrofluoroalkane 1,1-difluoroethane (HFA-152a) and HFA-1,1,1,2-tetrafluoroethane (134a)

  GlaxoSmithKline · recruiting · Asthma · study director
• Ph1
  NCT07626515 · A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Enicepatide in Generally Healthy Adult Chinese Participants

  Hoffmann-La Roche · active not recruiting · Healthy Participants · study director
• Ph2
  NCT07620392 · An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

  Hoffmann-La Roche · recruiting · Rheumatoid Arthritis · study director
• Ph2
  NCT07614360 · Study of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple Myeloma

  GlaxoSmithKline · not yet recruiting · Multiple Myeloma · study director
• Ph1
  NCT07615868 · A Trial to Compare What the Body Does to Selatogrel and the Effect of Selatogrel in Chinese Adults With Chronic Coronary Syndrome

  Viatris Innovation GmbH · completed · Chronic Coronary Syndrome · study director
• Ph4
  NCT07609719 · A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

  Genentech, Inc. · recruiting · Multiple Sclerosis · study director
• Ph2
  NCT07598396 · A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis

  Hoffmann-La Roche · recruiting · Lupus, Systemic Lupus Erythematosus, Lupus Nephritis · study director
• Ph1
  NCT07600450 · A Study of GSK4771261 in Healthy Participants Aged 25 to 55 Years of Age Inclusive

  GlaxoSmithKline · recruiting · Kidney Disease · study director
• Ph2
  NCT07589686 · A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight

  Hoffmann-La Roche · not yet recruiting · Obesity or Overweight · study director
• Ph1
  NCT07588100 · A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy

  Hoffmann-La Roche · recruiting · Diabetic Retinopathy · study director
• Ph2/Ph3
  NCT07569081 · A Study Evaluating the Efficacy and Safety of Momelotinib in Participants With Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

  GlaxoSmithKline · not yet recruiting · VEXAS Syndrome · study director
• Ph1/Ph2
  NCT07567846 · A Study Evaluating the Safety, Pharmacokinetics, and Preliminary Activity of GDC-1261 in Participants With Advanced or Metastatic Prostate Cancer

  Genentech, Inc. · recruiting · Advanced Prostate Cancer, Metastatic Prostate Cancer · study director
• Ph1
  NCT07558915 · A Study to Evaluate RO7851624 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

  Genentech, Inc. · recruiting · Relapsed/Refractory Multiple Myeloma · study director
• Ph3
  NCT07555938 · Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

  Hoffmann-La Roche · recruiting · Multiple Myeloma · study director
• Ph3
  NCT07541079 · A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)

  Genentech, Inc. · recruiting · Early Breast Cancer · study director
• Ph3
  NCT07541170 · A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)

  Hoffmann-La Roche · recruiting · Non-small Cell Lung Cancer · study director
• N/A
  NCT07531719 · A Study of Risdiplam in Participants With Type I and Type II Spinal Muscle Atrophy (SMA)

  Hoffmann-La Roche · recruiting · Spinal Muscle Atrophy · study director
• N/A
  NCT07527741 · A Study to Assess Treatment Patterns and Treatment Adherence in Early HER2-positive Breast Cancer Participants After Treatment Decentralization

  Hoffmann-La Roche · recruiting · Early-stage HER2+ Breast Cancer · study director
• Ph2
  NCT07519395 · A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)

  GlaxoSmithKline · recruiting · Irritable Bowel Syndrome · study director
• Ph2
  NCT07503340 · A Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immunogenicity and Pharmacodynamic Effects of Subcutaneous Ocrelizumab Administration in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)

  Hoffmann-La Roche · not yet recruiting · Relapsing-remitting Multiple Sclerosis · study director
• Ph1
  NCT07499050 · A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight

  Hoffmann-La Roche · active not recruiting · Healthy Volunteers, Overweight or Obesity · study director
• Ph1
  NCT07495813 · A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease

  Hoffmann-La Roche · active not recruiting · Stable Coronary Artery Disease, Healthy Volunteers · study director
• Ph4
  NCT07483450 · A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Ocrelizumab in Participants With Relapsing Multiple Sclerosis and Primary Progressive Multiple Sclerosis

  Hoffmann-La Roche · active not recruiting · Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis · study director
• Ph3
  NCT07456033 · A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

  GlaxoSmithKline · recruiting · Asthma · study director
• N/A
  NCT07455136 · A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

  Hoffmann-La Roche · recruiting · Traumatic Brain Injury · study director
• Ph2
  NCT07448038 · A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events

  Genentech, Inc. · recruiting · Atherosclerosis · study director
• Ph1
  NCT07425522 · A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)

  Genentech, Inc. · recruiting · Diabetic Macular Edema · study director
• Ph3
  NCT07416526 · A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A

  Hoffmann-La Roche · recruiting · Hemophilia A · study director
• Ph3
  NCT07416604 · A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A

  Hoffmann-La Roche · recruiting · Hemophilia A · study director
• Ph1
  NCT07416552 · A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)

  Hoffmann-La Roche · recruiting · Metastatic Colorectal Cancer · study director
• Ph2/Ph3
  NCT07413939 · RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

  Hoffmann-La Roche · recruiting · HER2-positive Breast Cancer · study director
• Ph2
  NCT07405801 · A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

  Hoffmann-La Roche · recruiting · Breast Cancer · study director
• Ph1
  NCT07371468 · A Study of GSK5926371 in Participants With B-cell Driven Autoimmune Rheumatic Diseases (ARD)

  GlaxoSmithKline · recruiting · Systemic Lupus Erythematosus · study director
• Ph2
  NCT07368998 · To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer

  Hoffmann-La Roche · recruiting · Breast Cancer · study director
• Ph1
  NCT07358546 · A Study of Efimosfermin Alfa in Adults With Hepatic Impairment

  GlaxoSmithKline · recruiting · Non-alcoholic Fatty Liver Disease · study director
• Ph3
  NCT07351045 · A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

  Hoffmann-La Roche · recruiting · Obesity or Overweight · study director
• Ph3
  NCT07351058 · A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

  Hoffmann-La Roche · recruiting · Obesity or Overweight, Type 2 Diabetes Mellitus · study director
• N/A
  NCT07347600 · A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer

  Hoffmann-La Roche · recruiting · Locally Advanced Breast Cancer, Metastatic Breast Cancer · study director
• Ph1
  NCT07342114 · A Clinical Study to Evaluate the Effects of RO7875913 in Healthy Participants and of RO7875913 With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma

  Genentech, Inc. · active not recruiting · Healthy Volunteers, Relapsed Multiple Myeloma, Refractory Multiple Myeloma · study director
• Ph1
  NCT07335198 · A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Efimosfermin Alfa Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and White/European Ancestry

  GlaxoSmithKline · completed · Non-alcoholic Fatty Liver Disease · study director
• Ph1
  NCT07334080 · ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants

  Eccogene · recruiting · Metabolic Dysfunction-Associated Steatohepatitis · study director
• Ph1/Ph2
  NCT07332455 · First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

  GlaxoSmithKline · recruiting · Neoplasms, Prostate · study director
• Ph1
  NCT07329972 · A Study to Evaluate the Effect of Food and Proton Pump Inhibitor on the Pharmacokinetics of ZN-A-1041 in Healthy Participants

  Genentech, Inc. · completed · Healthy Volunteers · study director
• Ph2
  NCT07323576 · A Study to Evaluate the Efficacy and Safety of Inavolisib When Administered in Combination With Bevacizumab and FOLFOX or FOLFIRI as First Line Therapy in Participants With Colorectal Cancer

  Hoffmann-La Roche · withdrawn · Colorectal Cancer · study director
• Ph1
  NCT07301723 · A Trial to Evaluate the Absolute Bioavailability of Cenerimod in Healthy Male Participants

  Viatris Innovation GmbH · completed · Healthy Subjects · study director
• Ph3
  NCT07298421 · A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease

  Hoffmann-La Roche · recruiting · Moderately to Severely Active Crohns Disease · study director
• Ph2
  NCT07287150 · A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

  Hoffmann-La Roche · recruiting · Metastatic Castration-Resistant Prostate Cancer · study director
• Ph2
  NCT07288138 · A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

  Eccogene · recruiting · Metabolic Dysfunction-associated Steatohepatitis · study director
• N/A
  NCT07284121 · A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

  Hoffmann-La Roche · recruiting · Lung Cancer, Hepatocellular Carcinoma · study director
• Ph2
  NCT07282574 · A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)

  Hoffmann-La Roche · recruiting · Progressive Multiple Sclerosis · study director
• Ph1
  NCT07271693 · A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7806881 in Healthy Participants

  Hoffmann-La Roche · recruiting · Healthy Volunteers · study director
• Ph1
  NCT07246941 · A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease

  Hoffmann-La Roche · active not recruiting · Huntington's Disease · study director
• Ph3
  NCT07246889 · Study of AHB-137 in Participants With Chronic Hepatitis B (CHB) Treated With Nucleos(t)Ide Analogues (NAs)(AUSHINE)

  Ausper Biopharma Co., Ltd. · active not recruiting · Chronic Hepatitis B · study director
• Ph1
  NCT07234942 · A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)

  Hoffmann-La Roche · active not recruiting · Alzheimer's Disease · study director
• Ph1/Ph2
  NCT07226206 · A Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A

  Hoffmann-La Roche · recruiting · Hemophilia A · study director
• Ph2
  NCT07223697 · A Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis

  Hoffmann-La Roche · active not recruiting · Atopic Dermatitis · study director
• Ph3
  NCT07221188 · A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

  GlaxoSmithKline · recruiting · Non-alcoholic Fatty Liver Disease · study director
• Ph3
  NCT07221227 · A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

  GlaxoSmithKline · recruiting · Non-alcoholic Fatty Liver Disease · study director
• Ph1
  NCT07214766 · A Study to Assess the Bioequivalence of Trastuzumab Via Different Subcutaneous Delivery Platforms in Healthy Male Participants

  Genentech, Inc. · completed · Healthy Participants · study director
• Ph1
  NCT07214662 · A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer

  Genentech, Inc. · terminated · Breast Cancer · study director
• Ph1
  NCT07211659 · Trial of THEO-260 (Administered Via Intraperitoneal Route) in Ovarian Cancer Patients

  Theolytics Limited · recruiting · Ovarian Cancer · study director
• N/A
  NCT07200375 · An Observational Study of Glofitamab in Chinese Adult Participants With 2L Diffuse Large B-Cell Lymphoma

  Hoffmann-La Roche · recruiting · Diffuse Large B-Cell Lymphoma · study director
• Ph2
  NCT07201051 · A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With Bronchiectasis

  GlaxoSmithKline · recruiting · Bronchiectasis · study director
• Ph3
  NCT07201129 · A Research Trial to Assess if Cenerimod is Efficacious and Safe to Treat Active Lupus Nephritis on Top of Regular Treatment

  Viatris Innovation GmbH · recruiting · Nephritis, Lupus, Lupus Erythematosus, Systemic · study director
• Ph3
  NCT07177339 · eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 Inflammation

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph3
  NCT07177352 · Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

  Hoffmann-La Roche · recruiting · Alzheimers Disease · study director
• Ph2
  NCT07172022 · A Study to Evaluate Crovalimab in People With Antiphospholipid Syndrome (APS)

  Hoffmann-La Roche · withdrawn · Antiphospholipid Syndrome · study director
• Ph3
  NCT07174310 · A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

  Hoffmann-La Roche · recruiting · Parkinson's Disease · study director
• Ph3
  NCT07170150 · A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

  Hoffmann-La Roche · active not recruiting · Alzheimers Disease · study director
• Ph3
  NCT07169578 · A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

  Hoffmann-La Roche · active not recruiting · Alzheimers Disease · study director
• Ph1
  NCT07168356 · A Study to Evaluate Blood Levels of Bepirovirsen in Adult Participants With Severe or Moderate Kidney Disease

  GlaxoSmithKline · active not recruiting · Hepatitis B · study director
• Ph2
  NCT07161258 · A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)

  Hoffmann-La Roche · recruiting · Relapsing Multiple Sclerosis · study director
• Ph3
  NCT07158242 · A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis

  Hoffmann-La Roche · recruiting · Moderately to Severely Active Ulcerative Colitis · study director
• Ph1
  NCT07144111 · A Study to Evaluate the Effect of Moderate or Severe Hepatic Impairment on the Pharmacokinetics (PK) of Inavolisib

  Genentech, Inc. · completed · Hepatic Impairment · study director
• Ph1
  NCT07137585 · A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity

  Hoffmann-La Roche · active not recruiting · Type 2 Diabetes Mellitus, Obesity, Overweight · study director
• Ph2
  NCT07137598 · A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)

  Hoffmann-La Roche · recruiting · Rheumatoid Arthritis · study director
• Ph1
  NCT07133191 · A Trial to Compare What the Body Does to Selatogrel and the Effect of Selatogrel in Japanese and Caucasian Healthy Participants

  Viatris Innovation GmbH · completed · Healthy Volunteers · study director
• Ph2
  NCT07112872 · A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes

  Hoffmann-La Roche · active not recruiting · Type 2 Diabetes Mellitus · study director
• Ph2
  NCT07105709 · Open-label Extension Study in Participants With Early Alzheimer's Disease

  GlaxoSmithKline · recruiting · Alzheimer's Disease · study director
• Ph1/Ph2
  NCT07100106 · A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

  Genentech, Inc. · recruiting · Breast Cancer · study director
• Ph2
  NCT07081958 · A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity

  Hoffmann-La Roche · completed · Obesity or Overweight · study director
• Ph2
  NCT07074886 · A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

  Hoffmann-La Roche · active not recruiting · Multiple Sclerosis · study director
• N/A
  NCT07059273 · A COPD Data Registry for Participants With Frequent Exacerbations

  Hoffmann-La Roche · withdrawn · COPD · study director
• Ph2
  NCT07054190 · A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

  Hoffmann-La Roche · recruiting · Breast Cancer · study director
• Ph1
  NCT07051993 · A Study to Evaluate the Relative Bioavailability of Two Tablet Formulations Compared to Capsule Formulation and the Effect of Food and Proton Pump Inhibitor on ZN-A-1041 Tablet(s) in Healthy Participants

  Genentech, Inc. · completed · Healthy Participants · study director
• N/A
  NCT07050160 · Long-term Follow-up Study of Gene Therapy for Arrhythmogenic Cardiomyopathy Due to a Plakophilin-2 Pathogenic Variant

  Lexeo Therapeutics · enrolling by invitation · Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC · study director
• Ph1/Ph2
  NCT07037862 · A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping to Evaluate the Safety and Efficacy of ENTR-601-44

  Entrada Therapeutics, Inc. · recruiting · Duchenne Muscular Dystrophy (DMD) · study director
• Ph1/Ph2
  NCT07038824 · A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45

  Entrada Therapeutics, Inc. · recruiting · Duchenne Muscular Dystrophy (DMD) · study director
• Ph4
  NCT07025811 · A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment

  Hoffmann-La Roche · completed · Dry Eye Disease · study director
• Ph1
  NCT07025577 · A Study to Assess the Tolerability and Safety of Subcutaneously (SC) Administered Immunoglobulin G (IgG) With Varying Injection Conditions

  Genentech, Inc. · completed · Healthy Participants · study director
• Ph3
  NCT07020819 · An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)

  Annexon, Inc. · recruiting · Guillain-Barre Syndrome · study director
• Ph1
  NCT07008378 · A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodynamics of P-CD19CD20-ALLO1 in Participants With Multiple Sclerosis

  Genentech, Inc. · active not recruiting · Multiple Sclerosis · study director
• Ph3
  NCT06998524 · A Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease

  Hoffmann-La Roche · recruiting · Von Willebrand Disease, Type 3 · study director
• Ph1/Ph2
  NCT06990880 · A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer

  GlaxoSmithKline · recruiting · Neoplasms, Prostate · study director
• Ph1
  NCT06984341 · A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Pharmacodynamics, and Efficacy of P-CD19CD20-ALLO1 in Participants With Severe, Treatment-refractory Systemic Lupus Erythematosus (SLE)

  Genentech, Inc. · withdrawn · Systemic Lupus Erythematosus · study director
• Ph1
  NCT06982131 · A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants

  Hoffmann-La Roche · active not recruiting · Overweight, Obesity · study director
• Ph1
  NCT06979518 · A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GSK3862995B Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and European Ancestry

  GlaxoSmithKline · completed · Pulmonary Disease, Chronic Obstructive · study director
• Ph2
  NCT06979336 · A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

  Genentech, Inc. · recruiting · Ulcerative Colitis · study director
• Ph3
  NCT06979323 · Depemokimab Asthma Imaging and Bronchoscopy Sub-Study

  GlaxoSmithKline · recruiting · Asthma · study director
• N/A
  NCT06976606 · A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM

  Lexeo Therapeutics · recruiting · Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC · study director
• N/A
  NCT06975436 · Performance Study of the Cobas® BV/CV Test on Samples From Participants With and Without Symptoms of Bacterial Vaginosis and Candida Vaginitis

  Hoffmann-La Roche · completed · Bacterial Vaginosis, Candida Vaginitis · study director
• Ph2
  NCT06965413 · A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity

  Hoffmann-La Roche · active not recruiting · Obesity, Overweight, Overweight With One Weight Related Comorbidity · study director
• Ph2
  NCT06964165 · A Study Comparing Niraparib Versus Platinum-Taxane Doublet Chemotherapy as Neoadjuvant Treatment in Participants With Homologous Recombination-Deficient Stage III/IV Ovarian Cancer (COHORT-C)

  Tesaro, Inc. · terminated · Ovarian Neoplasms · study director
• Ph3
  NCT06961214 · Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph1
  NCT06961370 · A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

  Hoffmann-La Roche · terminated · Geographic Atrophy, Age-related Macular Degeneration · study director
• Ph3
  NCT06959095 · Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation

  GlaxoSmithKline · recruiting · Pulmonary Disease, Chronic Obstructive · study director
• Ph1
  NCT06934044 · A Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relapsed or Refractory Multiple Myeloma

  Hoffmann-La Roche · active not recruiting · Multiple Myeloma · study director
• Ph1
  NCT06903065 · A Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH Liver Fibrosis

  Hoffmann-La Roche · active not recruiting · MASH · study director
• Ph1
  NCT06884618 · A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

  Hoffmann-La Roche · recruiting · Neoplasms · study director
• N/A
  NCT06883240 · An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment

  Hoffmann-La Roche · active not recruiting · Von Willebrand Disease, Type 3 · study director
• Ph1
  NCT06880328 · 18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capacity in the Whole Striatum After 2 Weeks of Treatment With Ralmitaront or Placebo in Participants With Schizophrenia

  Hoffmann-La Roche · completed · Schizophrenia · study director
• N/A
  NCT06865482 · Clinical Course Of Disease In Participants With FA-CM

  Lexeo Therapeutics · recruiting · Friedreich Ataxia, Cardiomyopathy · study director
• Ph2
  NCT06863961 · A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis

  Hoffmann-La Roche · active not recruiting · Atopic Dermatitis · study director
• N/A
  NCT06862869 · Real World Clinical Outcomes of Resected ALK-Positive Early Stage NSCLC Patients Treated With Alectinib as Adjuvant Therapy

  Hoffmann-La Roche · recruiting · Carcinoma, Non-Small-Cell Lung · study director
• Ph1/Ph2
  NCT06850922 · A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination With Aflibercept or Faricimab in Participants With Diabetic Macular Edema

  Genentech, Inc. · completed · Diabetic Macular Edema · study director
• Ph1
  NCT06847854 · A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7497372 in Participants With Diabetic Macular Edema (DME)

  Genentech, Inc. · active not recruiting · Diabetic Macular Edema · study director
• Ph3
  NCT06847542 · A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

  Hoffmann-La Roche · recruiting · Neovascular Age-related Macular Degeneration · study director
• Ph1
  NCT06835465 · A Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Divarasib in Healthy Participants

  Genentech, Inc. · completed · Healthy Participants · study director
• Ph1/Ph2
  NCT06826612 · A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

  Hoffmann-La Roche · recruiting · Huntington Disease · study director
• Ph3
  NCT06819878 · A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

  Hoffmann-La Roche · recruiting · Moderately to Severely Active Crohns Disease · study director
• Ph3
  NCT06819891 · A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

  Hoffmann-La Roche · recruiting · Moderately to Severely Active Crohns Disease · study director
• Ph1
  NCT06816017 · A Study to Evaluate Eciskafusp Alfa in Combination With Bacillus Calmette-guerin (BCG) in Participants With BCG-unresponsive High-risk Non-muscle Invasive Bladder Cancer (NMIBC)

  Hoffmann-La Roche · withdrawn · Non-muscle Invasive Bladder Cancer · study director
• Ph1
  NCT06809608 · A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compound RO7795081

  Hoffmann-La Roche · completed · Healthy Participants · study director
• Ph1
  NCT06799884 · A Drug-drug Interaction Trial in Healthy Female Participants to Investigate the Effect of Aprocitentan on Combined Hormonal Contraceptives

  Idorsia Pharmaceuticals Ltd. · completed · Drug Drug Interaction · study director
• Ph3
  NCT06793215 · A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

  Hoffmann-La Roche · recruiting · Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer · study director
• Ph4
  NCT06795048 · A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

  Hoffmann-La Roche · active not recruiting · Neovascular Age-related Macular Degeneration (nAMD) · study director
• Ph3
  NCT06790693 · A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

  Hoffmann-La Roche · recruiting · Breast Cancer · study director
• N/A
  NCT06780150 · A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)

  Hoffmann-La Roche · recruiting · Multiple Sclerosis · study director
• Ph3
  NCT06774859 · Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Chinese Pediatric Participants 1 to <12 Years of Age With Influenza Symptoms

  Hoffmann-La Roche · completed · Influenza · study director
• Ph1
  NCT06771271 · A Study to Investigate RO7200220 as Monotherapy and in Combination With Ranibizumab in Participants With Diabetic and Uveitic Macular Edema

  Hoffmann-La Roche · completed · Diabetic Macular Edema, Uveitic Macular Edema · study director
• N/A
  NCT06746051 · A Study to Investigate How Respiratory Syncytial Virus (RSV) Infection Develops and Changes Over Time in Pediatric Participants

  Shionogi · completed · RSV Infections · study director
• N/A
  NCT06734117 · A Study of Elecsys® Troponin T hs Gen 6 in Participants With Symptoms of Acute Coronary Syndrome

  Hoffmann-La Roche · completed · Acute Coronary Syndrome, Myocardial Infarction · study director
• Ph1
  NCT06734234 · A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease

  GlaxoSmithKline · active not recruiting · Kidney Disease · study director
• Ph1
  NCT06734208 · A Study to Evaluate the Pharmacokinetics of Divarasib in Healthy Participants and Participants With Impaired Hepatic Function

  Genentech, Inc. · completed · Hepatic Impairment · study director
• Ph1
  NCT06733298 · A Study Investigating [14C]-Labeled RO7269162 in Healthy Male Participants

  Hoffmann-La Roche · completed · Healthy Volunteers · study director
• N/A
  NCT06723288 · A Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participants With Neovascular Age-related Macular Degeneration (nAMD)/Diabetic Macular Edema (DME)

  Hoffmann-La Roche · completed · Neovascular Age-related Macular Degeneration, Diabetic Macular Edema · study director
• Ph3
  NCT06716606 · A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)

  GlaxoSmithKline · recruiting · Connective Tissue Diseases · study director
• N/A
  NCT06704672 · Clinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in Range Compared With Self-Monitoring of Blood Glucose in Participants With Type 1 and Type 2 Diabetes Mellitus

  Hoffmann-La Roche · recruiting · Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus · study director
• Ph1
  NCT06693908 · A Study to Evaluate the Activity, and Safety of Vixarelimab in Participants With Moderate to Severe Active Ulcerative Colitis

  Genentech, Inc. · completed · Moderate to Severe Ulcerative Colitis · study director
• Ph1
  NCT06690138 · A Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Divarasib in Healthy Participants

  Genentech, Inc. · completed · Healthy Participants · study director
• N/A
  NCT06680817 · A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)

  Hoffmann-La Roche · active not recruiting · Neovascular Age-related Macular Degeneration, Diabetic Macular Edema · study director
• Ph1
  NCT06677957 · A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants

  Genentech, Inc. · completed · Healthy Participants · study director
• Ph3
  NCT06675955 · An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment

  Hoffmann-La Roche · recruiting · Multiple Sclerosis · study director
• N/A
  NCT06667414 · Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

  Hoffmann-La Roche · completed · Huntington Disease · study director
• Ph1/Ph2
  NCT06655818 · Sub-study of Belantamab Mafodotin (GSK2857916) as Monotherapy and in Combination With Dostarlimab (GSK4057190) in Participants With RRMM

  GlaxoSmithKline · terminated · Relapsed/Refractory Multiple Myeloma · study director
• Ph2
  NCT06628362 · A Study of Enicepatide (CT-388) in Participants Who Are Overweight or Obese With Type 2 Diabetes Mellitus

  Carmot Therapeutics, Inc. · completed · Overweight or Obese, Type 2 Diabetes Mellitus (T2DM) · study director

Grants

NIH projects from RePORTER, fetched 2026-11-11 19:45 UTC. A project is listed only when its grant number is on one of the trials above, or when the awardee institution matches an affiliation the registry gives for this name. Coverage is US federal funding only; UK and EU funders are not searched yet.

No NIH project could be tied to this name by a shared trial or a matching institution.