Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 00:59 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Response to Phenylketonuria to Tetrahydrobiopterin (BH4)
NCT00244218 · The University of Texas Medical Branch, Galveston · PHASE1 · terminated · last registry update 2021-09-21 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The FDA has approved Kuvan (BH4) as a therapeutic agent for phenylketonuria” | – | Registry record, The University of Texas Medical Branch, Galveston |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against PAH within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2022-04-27Results posted on the registry: University Hospitals Cleveland Medical Center, saproterin dihydrochloride (NCT02677870)
- 2022-01-20Also stopped (withdrawn): University of Massachusetts, Worcester, L-arginine + Sapropterin Dihydrochloride (NCT04054973)
- 2021-05-17Results posted on the registry: BioMarin Pharmaceutical, Sapropterin Dihydrochloride + Sapropterin Dihydrochloride and Vitamin C (NCT00532844)
- 2021-04-05Results posted on the registry: VA Office of Research and Development, BH4 + Placebo (NCT02530996)
- 2021-02-23Results posted on the registry: Augusta University, Tetrahydrobiopterin (BH4) (NCT02774226)
- 2021-01-28Results posted on the registry: BioMarin Pharmaceutical, Sapropterin Dihydrochloride (NCT00445978)
- 2021-01-07Results posted on the registry: BioMarin Pharmaceutical, Sapropterin Dihydrochloride (NCT00403494)
- 2020-12-22Results posted on the registry: BioMarin Pharmaceutical, sapropterin dihydrochloride (NCT00838435)
- 2020-09-25Results posted on the registry: BioMarin Pharmaceutical, Phenoptin (NCT00355264)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision