Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:17 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
An Open Label Study to Assess the Efficacy, Safety and Tolerability of COZAAR Plus (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) Possibly Titrated up to COZAAR Plus-F (Losartan Potassium 100mg/Hydrochlorothiazide 25mg) in Patients With Essential Hypertension (0954A-325)
NCT00449111 · Organon and Co · PHASE3 · terminated · last registry update 2024-08-15 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
No reason was published
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | The registry record gives no reason | – | Registry record, Organon and Co |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against AGTR1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-07-22Results posted on the registry: University of Alabama at Birmingham, Perindopril + Losartan (NCT03295734)
- 2025-07-10Results posted on the registry: Anna Stanhewicz, PhD, Losartan Potassium + Placebo (NCT04632589)
- 2025-07-09Results posted on the registry: Alnylam Pharmaceuticals, Indapamide + Amlodipine (NCT05103332)
- 2025-07-02Results posted on the registry: University of Texas Southwestern Medical Center, a drug against AGTR1 (NCT03354143)
- 2025-06-04Also stopped (terminated): University of Arizona, Angiotensin-(1-7) + Placebo for Angiotensin-(1-7) (NCT03252093)
- 2025-06-04Also stopped (suspended): University of Arizona, Angiotensin-(1-7) (NCT03159988)
- 2025-06-03Results posted on the registry: University of Iowa, Salsalate Oral Tablet + Placebo Oral Tablet (NCT03482440)
- 2025-02-25Results posted on the registry: Arbor Pharmaceuticals, Inc., Azilsartan Medoxomil Low-dose + Losartan (NCT02235909)
- 2025-02-18Results posted on the registry: Ionis Pharmaceuticals, Inc., Placebo + IONIS-AGT-LRx (NCT04714320)
- 2025-01-31Results posted on the registry: Vicore Pharma AB, C106 solution + Placebo (NCT05427253)
- 2025-01-22Results posted on the registry: Sean Collins, TXA127 + TRV027 (NCT04924660)
- 2024-12-31Results posted on the registry: Anna Stanhewicz, PhD, Compound 21 + Compound 21 + losartan (NCT05576155)
- 2024-12-27Results posted on the registry: Alnylam Pharmaceuticals, Placebo + ALN-AGT01 (NCT04936035)
- 2024-12-27Also stopped (withdrawn): Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS, Losartan + Gemcitabine (NCT05861336)
- 2024-12-09Results posted on the registry: Takeda, TAK-536 (NCT04668157)
- 2024-11-12Results posted on the registry: Vicore Pharma AB, C21 (NCT05831644)
- 2024-10-17Phase 3 first posted: Hyundai Pharm, Ezetimibe/Rosuvastatin/Candesartan/Amlodipine + Candesartan/Amlodipine (NCT06646354)
- 2024-09-27Results posted on the registry: Pfizer, losartan + dextromethorphan (NCT03864042)
- 2024-09-26Phase 3 first posted: Universität Münster, Angiotensin II + Noradrenalin (NCT06615102)
- 2024-09-23Phase 3 first posted: Eurofarma Laboratorios S.A., N0877 + Benicar HCT ® Tablets 40 mg/25 mg (NCT06608472)
- 2024-09-23Also stopped (withdrawn): NYU Langone Health, Losartan (NCT06333522)
- 2024-09-04Results posted on the registry: Alexander Flannery, Angiotensin II (NCT04558359)
- 2024-08-02Results posted on the registry: University of Kansas Medical Center, Losartan (NCT04335123)
- 2024-07-16Results posted on the registry: University of Wisconsin, Madison, Anti-Hypertensive (NCT05479097)
- 2024-07-03Results posted on the registry: Travere Therapeutics, Inc., sparsentan + irbesartan (NCT03762850)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision