Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:38 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study to Assess the Safety, Tolerability, and Pharmacodynamics of RTA 402 in Patients With Hepatic Dysfunction
NCT00550849 · Biogen · PHASE1/PHASE2 · terminated · last registry update 2025-05-30 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Enrollment discontinued after second cohort completed.” | – | Registry record, Biogen |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against PPARG within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-04-28Results posted on the registry: University of Maryland, Baltimore, Pioglitazone 15mg (NCT05582707)
- 2026-04-28Also stopped (terminated): University of Maryland, Baltimore, Pioglitazone 15mg (NCT05582707)
- 2026-03-19Results posted on the registry: United States Army Research Institute of Environmental Medicine, Pioglitazone 15mg (NCT06164665)
- 2026-02-20Phase 3 first posted: Zydus Therapeutics Inc., Saroglitazar Magnesium 1 mg + Placebo (NCT07424677)
- 2025-12-18Results posted on the registry: Zydus Therapeutics Inc., Saroglitazar Magnesium 4 mg Tablet + Placebo (NCT03617263)
- 2025-12-18Also stopped (terminated): Zydus Therapeutics Inc., Saroglitazar Magnesium 4 mg Tablet + Placebo (NCT03617263)
- 2025-10-14Phase 3 first posted: Zydus Therapeutics Inc., Saroglitazar magnesium 1 mg + Placebo (NCT07216235)
- 2025-09-02Also stopped (terminated): Zydus Therapeutics Inc., Saroglitazar Magnesium 4 mg + Placebo (NCT05211284)
- 2025-08-27Results posted on the registry: The University of Texas Health Science Center, Houston, Pioglitazone + Placebo (NCT05107765)
- 2025-08-12Also stopped (withdrawn): AbbVie, Mesalamine + Placebo (NCT05316220)
- 2025-07-16Results posted on the registry: Zydus Therapeutics Inc., Saroglitazar Magnesium 4 mg + Placebo (NCT05211284)
- 2025-07-09Phase 3 first posted: The University of Texas Health Science Center at San Antonio, Dapagliflozin 10mg Tab + Pioglitazone 15 MG and 30mg (NCT07056699)
- 2025-06-13Results posted on the registry: VA Office of Research and Development, a drug against PPARG (NCT03864146)
- 2025-06-11Also stopped (terminated): Biogen, Bardoxolone methyl (NCT03068130)
- 2025-06-04Also stopped (terminated): Biogen, Placebo capsules + Bardoxolone methyl capsules (NCT02657356)
- 2025-06-03Also stopped (terminated): Biogen, Bardoxolone methyl (NCT03749447)
- 2025-06-03Also stopped (terminated): Biogen, Bardoxolone methyl oral capsule + Placebo oral capsule (NCT03918447)
- 2025-05-29Also stopped (withdrawn): Biogen, Bardoxolone Methyl (NCT01551446)
- 2025-05-29Also stopped (withdrawn): Biogen, Bardoxolone Methyl 20 mg + Placebo (NCT01576887)
- 2025-05-29Also stopped (terminated): Biogen, Bardoxolone methyl + Bardoxolone methyl (NCT00529113)
- 2025-05-29Also stopped (terminated): Biogen, Placebo + Bardoxolone Methyl: 20 mg (NCT01351675)
- 2025-05-29Also stopped (terminated): Biogen, Bardoxolone Methyl (NCT01549769)
- 2025-05-29Also stopped (withdrawn): Biogen, Bardoxolone Methyl + Placebo (NCT01655186)
- 2025-04-30Results posted on the registry: Johns Hopkins University, Pioglitazone 30 mg (NCT04300127)
- 2025-04-27Phase 3 first posted: Sun Yat-sen University, Group A (triple combination therapy group) + Group B (standard therapy group) (NCT06946628)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision