Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:24 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Effect of ITF2357 on Mucosal Healing in Patients With Moderate-to-severe Active Crohn's Disease
NCT00792740 · Italfarmaco · PHASE1/PHASE2 · terminated · last registry update 2023-07-19 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “As no safety warnings were detected, Interim analysis from the first 40 patients recommends to stop the trial for futility” | – | Registry record, Italfarmaco |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against HDAC1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2024-07-12Results posted on the registry: pharmaand GmbH, Panobinostat Capsules + Bortezomib Injection (NCT02654990)
- 2024-07-08Results posted on the registry: Celgene, Azacitidine + Romidepsin (NCT03703375)
- 2024-06-06Also stopped (terminated): Abdullah Khan, Bortezomib + Daratumumab and Hyaluronidase-fihj (NCT04956302)
- 2024-05-03Results posted on the registry: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Azacitidine + Entinostat (NCT01928576)
- 2024-04-25Results posted on the registry: Pediatric Brain Tumor Consortium, LBH589 (NCT02717455)
- 2024-04-22Results posted on the registry: Mirati Therapeutics Inc., Glesatinib + Sitravatinib (NCT02954991)
- 2024-04-22Also stopped (terminated): Mirati Therapeutics Inc., Glesatinib + Sitravatinib (NCT02954991)
- 2024-04-10Results posted on the registry: Northwestern University, romidepsin + lenalidomide (NCT02232516)
- 2024-04-10Also stopped (terminated): German Center for Neurodegenerative Diseases (DZNE), N-hydroxy-N'-phenyl-octanediamide (Vorinostat) (NCT03056495)
- 2024-04-04Results posted on the registry: Memorial Sloan Kettering Cancer Center, Carfilzomib + Romidepsin (NCT02341014)
- 2024-03-25Also stopped (terminated): UNC Lineberger Comprehensive Cancer Center, Entinostat (NCT03361800)
- 2024-03-08Results posted on the registry: Memorial Sloan Kettering Cancer Center, Mocetinostat (NCT02282358)
- 2024-03-08Also stopped (terminated): Memorial Sloan Kettering Cancer Center, Mocetinostat (NCT02282358)
- 2024-03-04Also stopped (terminated): OHSU Knight Cancer Institute, Abemaciclib + Abiraterone (NCT03878524)
- 2024-02-28Results posted on the registry: Massachusetts General Hospital, Panobinostat + Pegylated Interferon-alpha2a (NCT02471430)
- 2024-02-26Also stopped (withdrawn): Masonic Cancer Center, University of Minnesota, FT538 + Vorinostat (NCT05700630)
- 2024-02-15Also stopped (terminated): Dana-Farber Cancer Institute, Marizomib + Panobinostat (NCT04341311)
- 2024-02-09Results posted on the registry: Italfarmaco, Givinostat + Clarithromycin (NCT05845567)
- 2024-02-09Results posted on the registry: University of Melbourne, Disulfiram, (National Drug Code) NDC 0378-4141-01 + Vorinostat, NDC 00006-0568-40 (NCT03198559)
- 2024-02-09Also stopped (terminated): University of Melbourne, Disulfiram, (National Drug Code) NDC 0378-4141-01 + Vorinostat, NDC 00006-0568-40 (NCT03198559)
- 2024-02-01Results posted on the registry: City of Hope Medical Center, Pembrolizumab + Vorinostat (NCT03150329)
- 2024-01-12Also stopped (withdrawn): M.D. Anderson Cancer Center, Busulfan + Clofarabine (NCT04220008)
- 2024-01-11Results posted on the registry: Italfarmaco, ITF2357 10 mg/mL + ITF2357 10 mg/mL (NCT04821063)
- 2024-01-10Results posted on the registry: Syndax Pharmaceuticals, entinostat + avelumab (NCT02915523)
- 2024-01-10Results posted on the registry: UNC Lineberger Comprehensive Cancer Center, Entinostat + Pembrolizumab (NCT03765229)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision