Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:40 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse
NCT01068782 · Exelixis · PHASE2 · terminated · last registry update 2026-02-25 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Enrollment in this study was terminated for business development reasons before completing one third of the expected subject population, no formal statistical testing was performed.” | – | Registry record, Exelixis |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against KDR within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-11-05Results posted on the registry: Academic and Community Cancer Research United, Paclitaxel + Ramucirumab (NCT04660760)
- 2026-11-03Results posted on the registry: Jonsson Comprehensive Cancer Center, sorafenib tosylate (NCT01624285)
- 2026-11-02Also stopped (suspended): National Cancer Institute (NCI), Cabozantinib S-malate + Ipilimumab (NCT05904080)
- 2026-10-27Also stopped (suspended): National Cancer Institute (NCI), Cabozantinib S-malate + Cisplatin (NCT05691478)
- 2026-10-21Results posted on the registry: The University of Texas Health Science Center at San Antonio, Sorafenib (SOR) + Hydroxychloroquine (HCQ) (NCT03037437)
- 2026-10-21Results posted on the registry: Floor Backes, MD, Lenvatinib + Paclitaxel (NCT04781088)
- 2026-10-15Results posted on the registry: Rohit Aggarwal, MD, Nintedanib + Placebo (NCT05799755)
- 2026-10-06Results posted on the registry: Memorial Sloan Kettering Cancer Center, Talazoparib + Axitinib (NCT04337970)
- 2026-10-01Also stopped (withdrawn): City of Hope Medical Center, Sturlimogene Erparepvec + Tivozanib (NCT07218692)
- 2026-09-28Results posted on the registry: Merck Sharp & Dohme LLC, Pembrolizumab/Vibostolimab Co-Formulation + Pembrolizumab (NCT05007106)
- 2026-09-23Phase 3 first posted: BeOne Medicines, BGB-B2033 + Lenvatinib (NCT07836530)
- 2026-09-16Phase 3 first posted: AbbVie, Telisotuzumab Adizutecan + Docetaxel (NCT07821684)
- 2026-09-14Results posted on the registry: Baylor Research Institute, Abemaciclib + Ramucirumab (NCT04921904)
- 2026-09-09Phase 3 first posted: EuroCityClinic LLC, lenvatinib pembrolizumab (NCT07809256)
- 2026-09-03Results posted on the registry: Merck Sharp & Dohme LLC, Lenvatinib + Pembrolizumab (NCT04246177)
- 2026-09-03Also stopped (terminated): Merck Sharp & Dohme LLC, Lenvatinib + Pembrolizumab (NCT04246177)
- 2026-08-31Results posted on the registry: University of Texas Southwestern Medical Center, a drug against KDR (NCT02956798)
- 2026-08-21Also stopped (terminated): Merck Sharp & Dohme LLC, Pembrolizumab + Lenvatinib (NCT04949256)
- 2026-08-17Results posted on the registry: Washington University School of Medicine, Ramucirumab + Pembrolizumab (NCT03650764)
- 2026-08-13Results posted on the registry: Merck Sharp & Dohme LLC, Pembrolizumab + Quavonlimab (NCT04305041)
- 2026-08-13Phase 3 first posted: Gruppo Oncologico del Nord-Ovest, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) + CAPOX (oxaliplatin/capecitabine) (NCT07763171)
- 2026-08-13Results posted on the registry: PureTech, Nintedanib 150 MG [Ofev] (NCT06717100)
- 2026-08-12Also stopped (terminated): Providence Health & Services, Pembrolizumab + Lenvatinib (NCT05308901)
- 2026-08-03Results posted on the registry: Hoffmann-La Roche, 5-Fluorouracil (5-FU) + Leucovorin (NCT03281369)
- 2026-08-03Also stopped (terminated): Hoffmann-La Roche, 5-Fluorouracil (5-FU) + Leucovorin (NCT03281369)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision