Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:17 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Find the Maximum Tolerated Dose of the Experimental Combination of the Drugs INC424 and BKM120 in Patients With Primary or Secondary Myelofibrosis
NCT01730248 · Novartis Pharmaceuticals · PHASE1 · terminated · last registry update 2020-12-19 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Decision by Sponsor to to terminate the study early.” | – | Registry record, Novartis Pharmaceuticals |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against JAK1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2021-10-12Phase 3 first posted: Eli Lilly and Company, Baricitinib (NCT05074420)
- 2021-09-24Phase 3 first posted: Incepta Pharmaceuticals Ltd, Baricitinib + Placebo (NCT05056558)
- 2021-07-22Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, Baricitinib + Placebo (NCT04972760)
- 2021-05-04Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, Rituximab + Tocilizumab (NCT04871191)
- 2021-05-03Phase 3 first posted: University Hospital, Bordeaux, baricitinib treatment + anti-TNF therapy (NCT04870203)
- 2020-12-31Phase 3 first posted: University of Alabama at Birmingham, targeted synthetic DMARD class + non-TNFi-biologic class (NCT04692493)
- 2020-11-10Phase 3 first posted: Pfizer, tofacitinib (NCT04624230)
- 2020-10-26Phase 3 first posted: Novartis Pharmaceuticals, Pelabresib + Ruxolitinib (NCT04603495)
- 2020-09-24Phase 3 first posted: Karyopharm Therapeutics Inc, Selinexor + Selinexor (NCT04562389)
- 2020-07-15Phase 3 first posted: AbbVie, Placebo for Navitoclax + Ruxolitinib (NCT04472598)
- 2020-07-13Phase 3 first posted: AbbVie, Navitoclax + Ruxolitinib (NCT04468984)
- 2020-05-11Phase 3 first posted: University of Oxford, Lopinavir-Ritonavir + Corticosteroid (NCT04381936)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision