Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 00:39 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy
NCT01765218 · Kristin R Hoffman · PHASE1/PHASE2 · terminated · last registry update 2024-06-11 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study was stopped early due to changes in the UC Davis guidelines on who qualified for therapeutic hypothermia and significant difficulty in recruitment of patients following the COVID19 pandemic.” | – | Registry record, Kristin R Hoffman |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CA2 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-05-31Also stopped (withdrawn): Janey Pratt, Topiramate + Phentermine (NCT04572217)
- 2025-05-23Results posted on the registry: University of Colorado, Denver, Phentermine + Immediate Release Topiramate (NCT04095104)
- 2025-04-11Also stopped (withdrawn): Stanford University, Topamax + Gabapentin (NCT04613024)
- 2025-04-02Results posted on the registry: Padagis LLC, Brinzolamide/brimonidine ophthalmic suspension + Simbrinza 0.2%/1% Ophthalmic Suspension (NCT04944290)
- 2025-04-01Also stopped (terminated): Universidad Peruana Cayetano Heredia, Acetazolamide + Dexamethasone (NCT02945527)
- 2025-03-20Results posted on the registry: Mayo Clinic, Placebo + Acetazolamide (NCT04679389)
- 2025-03-20Also stopped (terminated): Mayo Clinic, Placebo + Acetazolamide (NCT04679389)
- 2025-03-06Also stopped (terminated): Laboratorios Sophia S.A de C.V., PRO-122 + Timolol eye drops (NCT03193333)
- 2025-02-28Also stopped (terminated): VA Office of Research and Development, a drug against CA2 (NCT04581603)
- 2025-02-14Also stopped (terminated): Stadtspital Zürich, Furosemide + Metolazone (NCT05986773)
- 2025-02-14Also stopped (withdrawn): University of California, Los Angeles, Medical weight loss (NCT05812183)
- 2025-01-28Also stopped (suspended): University of Sao Paulo, Carbamazepine-Implant + Topiramate-Implant (NCT03307863)
- 2025-01-20Phase 3 first posted: Mansoura University, Dapagliflozin 10mg + Acetazolamide 500mg (NCT06783166)
- 2024-10-28Results posted on the registry: Ziekenhuis Oost-Limburg, Acetazolamide + Placebo (NCT03505788)
- 2024-10-16Results posted on the registry: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Propranolol + Pindolol (NCT01950520)
- 2024-09-25Also stopped (withdrawn): Henry Ford Health System, Acamprosate + Placebo (NCT06312800)
- 2024-09-19Also stopped (terminated): The Cleveland Clinic, Phentermine / Topiramate Extended Release Oral Capsule + naltrexone/bupropion extended-release (NCT04531176)
- 2024-08-23Also stopped (terminated): CT Glaucoma Associates, dorzolamide/timolol (NCT06369077)
- 2024-08-02Phase 3 first posted: Helwan University, Acetazolamide + Dapagliflozin 10mg (NCT06535529)
- 2024-07-22Results posted on the registry: The Cleveland Clinic, Phentermine / Topiramate Extended Release Oral Capsule + naltrexone/bupropion extended-release (NCT04531176)
- 2024-06-18Results posted on the registry: VIVUS LLC, VI-0521 + Phentermine (NCT05215418)
- 2024-05-02Results posted on the registry: University of California, San Diego, Acetazolamide + Eszopiclone (NCT04639193)
- 2024-04-19Results posted on the registry: Massachusetts General Hospital, Topiramate or Placebo (NCT00606411)
- 2024-04-04Phase 3 first posted: Kafrelsheikh University, Zonisamide 50 MG + Topiramate 50 MG (NCT06347497)
- 2024-03-01Also stopped (withdrawn): University of Alabama at Birmingham, [O-15]Water + Acetazolamide (NCT03806751)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision