Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 20:17 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery
NCT02097225 · National Cancer Institute (NCI) · PHASE1 · terminated · last registry update 2024-10-16 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Drug supply issues” | – | Registry record, National Cancer Institute (NCI) |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against BRAF within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-10-14Results posted on the registry: BeiGene, Tislelizumab + Sorafenib (NCT03412773)
- 2025-10-02Results posted on the registry: Day One Biopharmaceuticals, Inc., Tovorafenib (NCT04985604)
- 2025-10-02Also stopped (terminated): Day One Biopharmaceuticals, Inc., Tovorafenib (NCT04985604)
- 2025-10-02Phase 3 first posted: Nanfang Hospital, Southern Medical University, targeted drug (NCT07203352)
- 2025-09-18Also stopped (terminated): Novartis Pharmaceuticals, Spartalizumab + Dabrafenib (NCT02967692)
- 2025-09-17Results posted on the registry: Merck Sharp & Dohme LLC, favezelimab/pembrolizumab + regorafenib (NCT05064059)
- 2025-09-17Results posted on the registry: Merck Sharp & Dohme LLC, favezelimab/pembrolizumab + regorafenib (NCT05600309)
- 2025-09-10Results posted on the registry: Memorial Sloan Kettering Cancer Center, Regorafenib (NCT02098538)
- 2025-09-03Also stopped (suspended): JS InnoPharm, LLC, JSI-1187 + Dabrafenib (NCT04418167)
- 2025-08-24Results posted on the registry: Bhavana Konda, dabrafenib + trametinib (NCT01723202)
- 2025-08-21Phase 3 first posted: Shanghai JMT-Bio Inc., JMT101 + Irinotecan (NCT07134205)
- 2025-08-19Also stopped (terminated): Mayo Clinic, Dabrafenib + MEK-1/MEKK-1 Inhibitor E6201 (NCT05388877)
- 2025-08-14Also stopped (terminated): Day One Biopharmaceuticals, Inc., Tovorafenib + Tovorafenib Drug: Pimasertib (NCT07121829)
- 2025-08-08Also stopped (terminated): K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc, ZN-c3 + Encorafenib (NCT05743036)
- 2025-08-06Also stopped (withdrawn): M.D. Anderson Cancer Center, Cladribine + Cytarabine (NCT06474663)
- 2025-07-18Results posted on the registry: Institut du Cancer de Montpellier - Val d'Aurelle, Regorafenib + Irinotecan (NCT03829462)
- 2025-06-17Results posted on the registry: CytomX Therapeutics, CX-072 + ipilimumab (NCT03013491)
- 2025-06-17Also stopped (terminated): CytomX Therapeutics, CX-072 + ipilimumab (NCT03013491)
- 2025-06-08Results posted on the registry: ECOG-ACRIN Cancer Research Group, Binimetinib + Encorafenib (NCT04221438)
- 2025-05-28Phase 3 first posted: Second Affiliated Hospital, Zhejiang University, School of Medicine, Trifluridine/Tipiracil + Regorafenib + Trifluridine/tipiracil + bevacizumab (NCT06992648)
- 2025-05-15Phase 3 first posted: Ruijin Hospital, Decitabine + Sorafenib (BAY-43-9006),giritinib (NCT06972641)
- 2025-05-13Results posted on the registry: Grupo Español Multidisciplinar de Melanoma, encorafenib + binimetinib (NCT03898908)
- 2025-05-02Also stopped (withdrawn): Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Vemurafenib (NCT02145910)
- 2025-04-27Also stopped (withdrawn): Medical University of South Carolina, ABC294640 (NCT02939807)
- 2025-04-13Also stopped (terminated): Novartis Pharmaceuticals, LXH254 + LTT462 (NCT02974725)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision