Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:01 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Noctura400 Treatment for Diabetic Retinopathy (CANDLE)
NCT02207712 · PolyPhotonix Medical · NA · terminated · last registry update 2023-08-14 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Major protocol deviations compromised the study.” | – | Registry record, PolyPhotonix Medical |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against VEGFA within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2024-08-07Results posted on the registry: Unity Biotechnology, Inc., UBX1325 injection 50 μL + EYLEA® (aflibercept) Injection 2 mg (0.05mL) (NCT05275205)
- 2024-07-18Results posted on the registry: Kodiak Sciences Inc, KSI-301 + Aflibercept (NCT04049266)
- 2024-07-18Also stopped (terminated): Kodiak Sciences Inc, KSI-301 + Aflibercept (NCT04049266)
- 2024-07-11Phase 3 first posted: Ocular Therapeutix, Inc., OTX-TKI + Aflibercept (NCT06495918)
- 2024-07-10Results posted on the registry: Federation Francophone de Cancerologie Digestive, aflibercept + LV5FU2 (NCT02384759)
- 2024-07-09Phase 3 first posted: Regeneron Pharmaceuticals, Aflibercept 8 mg (NCT06491914)
- 2024-06-24Phase 3 first posted: Rophibio, Inc., RBS-001 Solution for intravitreal injection + Eylea® Solution for intravitreal injection (NCT06470373)
- 2024-06-06Results posted on the registry: Kodiak Sciences Inc, KSI-301 + Aflibercept (NCT04592419)
- 2024-06-04Results posted on the registry: Novartis Pharmaceuticals, RTH258/Brolucizumab (NCT04239027)
- 2024-05-30Also stopped (withdrawn): Asociación para Evitar la Ceguera en México, intravitreal injection of ranibizumab + intravitreal injection of triamcinolone (NCT00930189)
- 2024-05-21Phase 3 first posted: Bayer, 8 mg aflibercept (BAY 86-5321) (High Dose) + 2 mg aflibercept (EYLEA, BAY 86-5321) (NCT06422507)
- 2024-05-06Results posted on the registry: Moorfields Eye Hospital NHS Foundation Trust, Aflibercept (NCT02661711)
- 2024-05-02Results posted on the registry: Kodiak Sciences Inc, KSI-301 + Aflibercept (NCT04964089)
- 2024-04-25Results posted on the registry: Jaeb Center for Health Research, intravitreous aflibercept + Bevacizumab + Deferred Aflibercept Group (NCT03321513)
- 2024-04-04Results posted on the registry: Novartis Pharmaceuticals, brolucizumab (NCT04597632)
- 2024-03-26Results posted on the registry: Sandoz, SOK583A1 (40 mg/mL) + Eylea EU (40 mg/mL) (NCT04864834)
- 2024-03-22Also stopped (withdrawn): Wake Forest University Health Sciences, Ranibizumab + Triamcinolone Acetonide (NCT04075136)
- 2024-03-12Phase 3 first posted: Incepta Pharmaceuticals Ltd, Ranibizumab 10mg/ml Injection + Lucentis (NCT06305416)
- 2024-02-23Also stopped (terminated): Ophthotech Corporation, Fovista® (anti-PDGF BB) plus anti-VEGF (NCT02214628)
- 2024-02-21Also stopped (withdrawn): Ophthotech Corporation, Zimura + Eylea (NCT03374670)
- 2024-02-05Results posted on the registry: Samsung Bioepis Co., Ltd., SB15 (Proposed aflibercept biosimilar) + Eylea (Aflibercept) (NCT04450329)
- 2024-01-30Results posted on the registry: Novartis Pharmaceuticals, Brolucizumab 6 mg + Aflibercept 2 mg (NCT04005352)
- 2024-01-25Phase 3 first posted: Ocular Therapeutix, Inc., OTX-TKI (axitinib implant) + Aflibercept (NCT06223958)
- 2024-01-18Results posted on the registry: Hoffmann-La Roche, Faricimab + Aflibercept (NCT04740905)
- 2024-01-18Results posted on the registry: Hoffmann-La Roche, Faricimab + Aflibercept (NCT04740931)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision