Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 22:02 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1
NCT02574910 · University of Texas Southwestern Medical Center · PHASE1 · terminated · last registry update 2025-11-04 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study has been affected significantly by the COVID pandemic, drug supply/drug amendment, low recruitment interest, and FDA approval of another drug with the same indication, so this study has not met its primary endpoint data requirements.” | – | Registry record, University of Texas Southwestern Medical Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CYP17A1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-10-01Phase 3 first posted: ECOG-ACRIN Cancer Research Group, Abiraterone Acetate + Cabazitaxel (NCT07852195)
- 2026-09-25Results posted on the registry: CellCentric Ltd., CCS1477 + Abiraterone acetate (NCT03568656)
- 2026-09-10Results posted on the registry: AstraZeneca, Capivasertib + Abiraterone Acetate (NCT04493853)
- 2026-09-03Phase 3 first posted: GlaxoSmithKline, Risvutatug rezetecan (Ris-Rez) + Enzalutamide (NCT07802704)
- 2026-08-31Results posted on the registry: Alliance for Clinical Trials in Oncology, a drug against CYP17A1 (NCT05241860)
- 2026-08-26Results posted on the registry: Amgen, Acapatamab + Enzalutamide (NCT04631601)
- 2026-08-26Also stopped (terminated): Amgen, Acapatamab + Enzalutamide (NCT04631601)
- 2026-08-07Phase 3 first posted: University College, London, Abiraterone, Apalutamide, Enzalutamide or Darolutamide (ARPI therapy) (per standard of care) therapy (NCT07751133)
- 2026-07-23Phase 3 first posted: ORIC Pharmaceuticals, Rinzimetostat + Darolutamide (NCT07723248)
- 2026-07-22Also stopped (terminated): Mayo Clinic, Abiraterone Acetate/Niraparib + Prednisone (NCT05689021)
- 2026-07-17Phase 3 first posted: AstraZeneca, Saruparib + Enzalutamide (NCT07711002)
- 2026-06-11Phase 3 first posted: Sichuan Baili Pharmaceutical Co., Ltd., BL-B01D1 + Abiraterone (NCT07641855)
- 2026-06-02Phase 3 first posted: Exelixis, Cabozantinib + Zanzalintinib (NCT07620574)
- 2026-05-28Phase 3 first posted: AstraZeneca, Actinium (225Ac) zadavotide guraxetan (AZD2265 [FPI-2265]) + Cabazitaxel (NCT07611110)
- 2026-05-26Results posted on the registry: Masonic Cancer Center, University of Minnesota, Cabazitaxel + Carboplatin (NCT03934840)
- 2026-05-15Results posted on the registry: Corcept Therapeutics, Exicorilant + Enzalutamide (NCT03437941)
- 2026-05-15Also stopped (terminated): Corcept Therapeutics, Exicorilant + Enzalutamide (NCT03437941)
- 2026-05-14Results posted on the registry: Royal Marsden NHS Foundation Trust, a drug against CYP17A1 (NCT03644303)
- 2026-04-28Results posted on the registry: Arvinas Androgen Receptor, Inc., Bavdegalutamide + Abiraterone (NCT05177042)
- 2026-04-27Also stopped (terminated): Partner Therapeutics, Inc., Afatinib Oral Tablet + Enzalutamide Pill (NCT05588609)
- 2026-04-24Results posted on the registry: Memorial Sloan Kettering Cancer Center, Atezolizumab + Abiraterone (NCT04262154)
- 2026-04-13Results posted on the registry: Memorial Sloan Kettering Cancer Center, ARN-509 + Abiraterone (NCT02772588)
- 2026-04-08Also stopped (withdrawn): Qian Qin, Androgen Deprivation Therapy (ADT) + Niraparib/Abiraterone Acetate DAT (NCT06392841)
- 2026-03-16Also stopped (terminated): M.D. Anderson Cancer Center, Abiraterone Acetate + Apalutamide (NCT03360721)
- 2026-03-10Results posted on the registry: Epizyme, Inc., Tazemetostat + Abiraterone/prednisone (NCT04179864)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision