Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 18:07 UTC. Every row links to its source record.

Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time

Strategy to Prevent the Onset of Clinically-Apparent Rheumatoid Arthritis

NCT02603146 · National Institute of Allergy and Infectious Diseases (NIAID) · PHASE2 · terminated · last registry update 2025-06-12 · Decision brief

No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.

What was said, and by whom

Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.

Kind	Quote	Our category	Source
Stated	“Enrollment was closed before reaching the target. In the 1st interim analysis after enrollment closure, the follow up \& treatment of active participants were stopped early due to evidence of futility.”	–	Registry record, National Institute of Allergy and Infectious Diseases (NIAID)

Also happening at the time. Not shown to be a cause.

Registry events on other trials of drugs against TLR7 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.

What is not public

Internal portfolio and board discussions
Unpublished trial data and interim analyses
Terms of any partner or licence decision