Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 21:23 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis
NCT02718300 · Incyte Corporation · PHASE2 · terminated · last registry update 2024-05-01 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “A business decision was made to discontinue further enrollment. There were no safety concerns that contributed to this decision.” | – | Registry record, Incyte Corporation |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against PIK3CD within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-04-16Results posted on the registry: National Cancer Institute (NCI), Copanlisib (NCT06400238)
- 2025-04-16Results posted on the registry: National Cancer Institute (NCI), Copanlisib (NCT06360588)
- 2025-03-24Results posted on the registry: Kazia Therapeutics Limited, Paxalisib (GDC-0084) (NCT03522298)
- 2025-03-07Results posted on the registry: Loxo Oncology, Inc., Pirtobrutinib + Idelalisib (NCT04666038)
- 2025-03-04Results posted on the registry: Columbia University, Copanlisib (NCT04750941)
- 2025-03-04Also stopped (terminated): Columbia University, Copanlisib (NCT04750941)
- 2025-02-28Results posted on the registry: Memorial Sloan Kettering Cancer Center, Vemurafenib + Copanlisib (NCT04462471)
- 2025-02-27Results posted on the registry: Jennifer R. Brown, MD, PhD, Acalabrutinib + Umbralisib (NCT04624633)
- 2025-02-26Phase 3 first posted: BeOne Medicines, Tacabrutideg + Bendamustine (NCT06846671)
- 2025-01-15Results posted on the registry: Incyte Corporation, parsaclisinib + placebo (NCT05073458)
- 2025-01-03Phase 3 first posted: Celcuity Inc, Arm A: Gedatolisib + Palbociclib + Fulvestrant + Arm B: Ribociclib + Fulvestrant (NCT06757634)
- 2024-12-31Also stopped (terminated): MEI Pharma, Inc., Zandelisib (ME-401) (NCT03768505)
- 2024-12-13Also stopped (terminated): TG Therapeutics, Inc., Obinutuzumab + Ublituximab (NCT02612311)
- 2024-12-11Results posted on the registry: Bayer, Copanlisib (BAY80-6946) + Placebo (NCT02626455)
- 2024-12-11Also stopped (terminated): Bayer, Copanlisib (BAY80-6946) + Placebo (NCT02626455)
- 2024-11-21Results posted on the registry: Fondazione Italiana Linfomi - ETS, Idelalisib + Obinutuzumab (NCT03890289)
- 2024-11-21Also stopped (terminated): Fondazione Italiana Linfomi - ETS, Idelalisib + Obinutuzumab (NCT03890289)
- 2024-11-05Results posted on the registry: Dana-Farber Cancer Institute, BKM120 + Cisplatin (NCT02113878)
- 2024-11-04Also stopped (terminated): MEI Pharma, Inc., Zandelisib + Rituximab (NCT04745832)
- 2024-10-31Also stopped (withdrawn): Memorial Sloan Kettering Cancer Center, Copanlisib + Degarelix (NCT06218667)
- 2024-10-16Results posted on the registry: Dana-Farber Cancer Institute, Idelalisib + Ofatumumab (NCT02135133)
- 2024-10-04Results posted on the registry: Incyte Corporation, parsaclisib + ruxolitinib (NCT04551066)
- 2024-09-27Also stopped (terminated): University of Michigan Rogel Cancer Center, Copanlisib + Nivolumab (NCT04431635)
- 2024-09-19Results posted on the registry: University of Maryland, Baltimore, Zydelig (NCT03133221)
- 2024-08-23Results posted on the registry: Incyte Corporation, parsaclisib + ruxolitinib (NCT04551053)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision