Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 04:02 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma
NCT02723006 · Millennium Pharmaceuticals, Inc. · PHASE1 · terminated · last registry update 2024-03-05 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Business decision: Protocol efficacy futility met” | – | Registry record, Millennium Pharmaceuticals, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against RAF1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-02-26Also stopped (terminated): Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Sorafenib (NCT04709380)
- 2025-02-24Phase 3 first posted: Shandong Cancer Hospital and Institute, Systemic therapy (Continuation of current first-line systemic therapy) + Systemic therapy (Early switch to second-line systemic therapy) (NCT06841172)
- 2025-02-12Also stopped (terminated): Georgetown University, Temozolomide + ABT-888 (NCT01205828)
- 2025-02-11Phase 3 first posted: Children's Oncology Group, Cyclophosphamide + Doxorubicin Hydrochloride (NCT06820957)
- 2025-02-11Results posted on the registry: Robin Kate Kelley, Nivolumab + Sorafenib (NCT03439891)
- 2025-01-24Results posted on the registry: Kohei Shitara, Regorafenib + Nivolumab (NCT03406871)
- 2025-01-15Results posted on the registry: Institut du Cancer de Montpellier - Val d'Aurelle, Folfirinox + regorafenib (NCT03828799)
- 2025-01-07Results posted on the registry: Eisai Inc., E7080 + Comparator Drug (NCT03477175)
- 2024-12-11Results posted on the registry: ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-12-11Also stopped (terminated): ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-11-21Also stopped (withdrawn): City of Hope Medical Center, Balstilimab + Botensilimab (NCT06575725)
- 2024-11-20Also stopped (terminated): Astellas Pharma Inc, OSI-906 + Placebo (NCT01101906)
- 2024-10-15Results posted on the registry: EpicentRx, Inc., RRx-001 + Regorafenib (NCT02096354)
- 2024-10-04Results posted on the registry: Asan Medical Center, Regorafenib (NCT02175095)
- 2024-09-27Results posted on the registry: Academic and Community Cancer Research United, Cetuximab + Irinotecan (NCT04117945)
- 2024-09-25Results posted on the registry: Hutchison Medipharma Limited, Fruquintinib (HMPL-013) (NCT03251378)
- 2024-09-19Also stopped (terminated): Taiho Oncology, Inc., TAC-101 + Placebo (NCT00687596)
- 2024-07-23Results posted on the registry: Bayer, Regorafenib, (Stivarga, BAY73-4506) + Nivolumab (Opdivo) (NCT04704154)
- 2024-06-26Results posted on the registry: Wake Forest University Health Sciences, Regorafenib (NCT02581059)
- 2024-06-26Also stopped (terminated): Wake Forest University Health Sciences, Regorafenib (NCT02581059)
- 2024-06-05Results posted on the registry: Theseus Pharmaceuticals, THE-630 (NCT05160168)
- 2024-06-05Also stopped (terminated): Theseus Pharmaceuticals, THE-630 (NCT05160168)
- 2024-05-29Results posted on the registry: Roswell Park Cancer Institute, Pembrolizumab + Sorafenib Tosylate (NCT03211416)
- 2024-05-21Results posted on the registry: Academic and Community Cancer Research United, Panitumumab + Regorafenib (NCT03992456)
- 2024-04-29Also stopped (withdrawn): M.D. Anderson Cancer Center, Regorafenib + XmAb20717 (NCT05900648)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision