Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 07:05 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Evaluate Efficacy and Safety of Ivacaftor in Subjects With Cystic Fibrosis Aged 3 Through 5 Years Who Have a Specified CFTR Gating Mutation
NCT02742519 · Vertex Pharmaceuticals Incorporated · PHASE3 · terminated · last registry update 2018-11-19 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Low enrollment.” | – | Registry record, Vertex Pharmaceuticals Incorporated |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CFTR within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2019-10-29Results posted on the registry: Vertex Pharmaceuticals Incorporated, LUM/IVA + LUM/IVA (NCT02544451)
- 2019-10-17Results posted on the registry: Vertex Pharmaceuticals Incorporated, VX-659/TEZ/IVA + TEZ/IVA (NCT03460990)
- 2019-09-26Phase 3 first posted: Vertex Pharmaceuticals Incorporated, ELX/TEZ/IVA + TEZ/IVA (NCT04105972)
- 2019-09-12Results posted on the registry: Vertex Pharmaceuticals Incorporated, Tezacaftor/Ivacaftor + Ivacaftor (NCT03150719)
- 2019-08-21Results posted on the registry: Vertex Pharmaceuticals Incorporated, Tezacaftor/Ivacaftor + Ivacaftor (NCT02730208)
- 2019-08-15Phase 3 first posted: Vertex Pharmaceuticals Incorporated, ELX/TEZ/IVA + IVA (NCT04058366)
- 2019-08-15Phase 3 first posted: Vertex Pharmaceuticals Incorporated, ELX/TEZ/IVA + IVA (NCT04058353)
- 2019-08-02Phase 3 first posted: Vertex Pharmaceuticals Incorporated, ELX/TEZ/IVA + IVA (NCT04043806)
- 2019-07-31Also stopped (withdrawn): Massachusetts General Hospital, Lumacaftor-ivacaftor (NCT02653027)
- 2019-07-19Results posted on the registry: University of Alabama at Birmingham, Ivacaftor/Ataluren (NCT03256799)
- 2019-06-17Results posted on the registry: Vertex Pharmaceuticals Incorporated, LUM/IVA + Placebo (NCT02875366)
- 2019-01-08Results posted on the registry: Vertex Pharmaceuticals Incorporated, Ivacaftor + Tezacaftor/Ivacaftor (NCT02412111)
- 2018-10-30Results posted on the registry: Vertex Pharmaceuticals Incorporated, LUM/IVA (NCT02797132)
- 2018-10-02Phase 3 first posted: Vertex Pharmaceuticals Incorporated, ELX/TEZ/IVA + IVA (NCT03691779)
- 2018-10-02Results posted on the registry: Vertex Pharmaceuticals Incorporated, LUM/IVA + Placebo (NCT03061331)
- 2018-09-27Results posted on the registry: Vertex Pharmaceuticals Incorporated, LUM/IVA (NCT02823470)
- 2018-09-27Also stopped (terminated): Vertex Pharmaceuticals Incorporated, LUM/IVA (NCT02823470)
- 2018-08-16Phase 3 first posted: Vertex Pharmaceuticals Incorporated, VX-659/TEZ/IVA + IVA (NCT03633526)
- 2018-08-06Results posted on the registry: Medical University of South Carolina, Ivacaftor (NCT02934698)
- 2018-07-27Results posted on the registry: Vertex Pharmaceuticals Incorporated, Tezacaftor/Ivacaftor + Ivacaftor (NCT02508207)
- 2018-07-26Phase 3 first posted: Vertex Pharmaceuticals Incorporated, LUM + IVA (NCT03601637)
- 2018-06-15Phase 3 first posted: Vertex Pharmaceuticals Incorporated, TEZ/IVA + IVA (NCT03559062)
- 2018-06-12Results posted on the registry: Vertex Pharmaceuticals Incorporated, VX-661 Plus Ivacaftor Combination + Ivacaftor (NCT02347657)
- 2018-06-12Results posted on the registry: Vertex Pharmaceuticals Incorporated, VX-661 plus ivacaftor combination + Ivacaftor (NCT02516410)
- 2018-06-12Results posted on the registry: Vertex Pharmaceuticals Incorporated, VX-661/Ivacaftor + Ivacaftor (NCT02392234)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision