Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 06:03 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty
NCT02987920 · University of Southern California · PHASE4 · terminated · last registry update 2019-05-14 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The surgeon changed pain control protocol for all patients. Continued enrollment impossible under approved protocol.” | – | Registry record, University of Southern California |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against SIGMAR1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2019-10-29Also stopped (terminated): St. Joseph's Hospital and Medical Center, Phoenix, Nuedexta (20/10) (NCT01832350)
- 2019-07-31Phase 3 first posted: Axsome Therapeutics, Inc., AXS-05 (dextromethorphan and bupropion) oral tablets (NCT04039022)
- 2019-07-15Phase 3 first posted: Axsome Therapeutics, Inc., AXS-05 + Placebo (NCT04019704)
- 2019-06-24Results posted on the registry: GlaxoSmithKline, Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg + Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg (NCT03415243)
- 2019-03-12Results posted on the registry: Eli Lilly and Company, Drug Cocktail + Ixekizumab (NCT02993471)
- 2019-02-26Phase 3 first posted: The University of Texas Health Science Center, Houston, Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg) + Placebo (NCT03854019)
- 2019-01-16Results posted on the registry: Shire, Digoxin + Maribavir (NCT02775240)
- 2018-10-23Results posted on the registry: Hugo W. Moser Research Institute at Kennedy Krieger, Inc., dextromethorphan + placebo (NCT01520363)
- 2018-06-29Results posted on the registry: University of Washington, Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan (NCT01361217)
- 2018-06-11Results posted on the registry: James Murrough, dextromethorphan/quinidine (NCT01882829)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision