Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:21 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)
NCT03085810 · Hoffmann-La Roche · PHASE3 · terminated · last registry update 2025-01-15 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study was terminated earlier as the study sponsor collected sufficient data to perform all analyses as per pre-specified endpoints in the study protocol.” | – | Registry record, Hoffmann-La Roche |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against MS4A1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-01-06Phase 3 first posted: Biocad, BCD-281 + Ocrelizumab (NCT07321093)
- 2025-12-30Results posted on the registry: Massachusetts General Hospital, 11C-PBR28 (NCT04230174)
- 2025-11-28Also stopped (withdrawn): The University of Queensland, Obinutuzumab + Oral prednisolone and cyclophosphamide (NCT06120673)
- 2025-11-10Phase 3 first posted: Genmab, Epcoritamab + Investigator's Choice Chemotherapy (NCT07226752)
- 2025-11-06Results posted on the registry: Hoffmann-La Roche, Obinutuzumab + MMF (NCT04221477)
- 2025-10-23Phase 3 first posted: TG Therapeutics, Inc., Ublituximab + Placebo (NCT07220252)
- 2025-10-08Phase 3 first posted: TG Therapeutics, Inc., Ublituximab + Ublituximab (NCT07211633)
- 2025-09-23Phase 3 first posted: University Hospital, Montpellier, Platform therapies (Dimethyl Fumarate, Teriflunomide, Glatiramer Acetate, Beta-interferons) + Anti-CD20 therapies (Ocrelizumab, Rituximab, Ofatumumab) (NCT07189325)
- 2025-09-17Also stopped (withdrawn): M.D. Anderson Cancer Center, Glofitamab (NCT06670105)
- 2025-09-15Results posted on the registry: University of California, San Diego, GA101 + Ibrutinib (NCT02315768)
- 2025-09-09Phase 3 first posted: Radboud University Medical Center, Obinutuzumab administration (NCT07163611)
- 2025-08-12Results posted on the registry: Dana-Farber Cancer Institute, Venetoclax + Obinutuzumab (NCT03580928)
- 2025-08-06Results posted on the registry: Emory University, Bendamustine + Obinutuzumab (NCT03872180)
- 2025-07-22Also stopped (terminated): University of Washington, Pembrolizumab + Rituximab (NCT03401853)
- 2025-07-09Also stopped (terminated): Mayo Clinic, Rituximab (NCT02320292)
- 2025-06-24Results posted on the registry: M.D. Anderson Cancer Center, Lenalidomide + Obinutuzumab (NCT01995669)
- 2025-06-06Results posted on the registry: Weill Medical College of Cornell University, Acalabrutinib + Lenalidomide (NCT03863184)
- 2025-05-22Results posted on the registry: Hoffmann-La Roche, Ocrelizumab (NCT04998812)
- 2025-05-14Phase 3 first posted: BeOne Medicines, BGB-16673 + Bendamustine (NCT06970743)
- 2025-04-24Phase 3 first posted: BeOne Medicines, Sonrotoclax + Obinutuzumab (NCT06943872)
- 2025-04-20Results posted on the registry: National Cancer Institute (NCI), Obinutuzumab + Prednisone (NCT05211336)
- 2025-04-18Results posted on the registry: University of Washington, Pembrolizumab + Rituximab (NCT03401853)
- 2025-04-17Results posted on the registry: Hoffmann-La Roche, Obinutuzumab + Venetoclax (NCT04285567)
- 2025-04-16Results posted on the registry: Hoffmann-La Roche, Ocrelizumab (NCT04998851)
- 2025-03-12Results posted on the registry: Dana-Farber Cancer Institute, Obinutuzumab + Placebo (NCT02867384)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision