Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 17:22 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Phase III Efficacy and Tolerability Trial of the Fixed Dose Combination of Etodolac 400 mg and Cyclobenzaprine 10 mg Versus Isolated Active Substances in Pain Control After Impacted Third Molar Extraction
NCT03127592 · Apsen Farmaceutica S.A. · PHASE3 · terminated · last registry update 2026-09-09 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “recruitment difficulty” | – | Registry record, Apsen Farmaceutica S.A. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CHRM3 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-10-05Phase 3 first posted: Chiesi Farmaceutici S.p.A., CHF5993 100/6/12.5 μg pMDI HFA-152a + Seretide Evohaler (NCT07858123)
- 2026-10-02Also stopped (suspended): Medical University of Bialystok, Tiotropium + Olodaterol (NCT07541378)
- 2026-09-14Also stopped (terminated): Immunovant Sciences GmbH, Batoclimab 680 mg SC weekly + Batoclimab 340 mg SC weekly (NCT05403541)
- 2026-09-03Also stopped (suspended): Chia Tai Tianqing Pharmaceutical Group Co., Ltd., TQC3927 inhalation aerosol + Glyceryl bromide/formoterol inhalation aerosol (NCT07633314)
- 2026-08-18Also stopped (terminated): CAMC Health System, Valproate + Lorazepam (NCT03235531)
- 2026-08-14Phase 3 first posted: Axsome Therapeutics, Inc., AXS-05 (dextromethorphan-bupropion) + Bupropion (NCT07766655)
- 2026-08-10Results posted on the registry: argenx, Efgartigimod IV (NCT06298552)
- 2026-07-29Results posted on the registry: Emory University, Botulinum toxin (NCT05125029)
- 2026-07-02Results posted on the registry: AstraZeneca, BGF MDI 320/28.8/9.6 μg + BGF MDI 320/14.4/9.6 μg (NCT04609904)
- 2026-06-30Results posted on the registry: AstraZeneca, BGF MDI 320/28.8/9.6 μg + BGF MDI 320/14.4/9.6 μg (NCT04609878)
- 2026-06-26Results posted on the registry: Chiesi Farmaceutici S.p.A., CHF 5993 100/6/12.5 + CHF 1535 100/6 µg (NCT02676076)
- 2026-05-29Results posted on the registry: Chiesi Farmaceutici S.p.A., CHF 5993 200/6/12.5 µg + CHF 1535 200/6 µg (NCT02676089)
- 2026-05-27Results posted on the registry: Chiesi Farmaceutici S.p.A., CHF 5993 100/6/12.5 µg + 160 µg budesonide + 4.5 µg formoterol fumarate (NCT03197818)
- 2026-05-13Also stopped (terminated): University Hospital, Linkoeping, Acetylcholine + Norepinephrine (NCT04777383)
- 2026-04-23Phase 3 first posted: Chiesi Farmaceutici S.p.A., Experimental: Participant Group CHF 5993 pMDI HFA-152a (NCT07546981)
- 2026-04-09Results posted on the registry: Chiesi Farmaceutici S.p.A., Beclomethasone dipropionate/Formoterol Fumarate/Glycopyrronium (BDP/FF/GB) (NCT04876677)
- 2026-04-08Also stopped (withdrawn): Assistance Publique - Hôpitaux de Paris, a drug against CHRM3 (NCT02138708)
- 2026-02-27Results posted on the registry: Penn State University, Acetylcholine + Sodium Nitroprusside (NCT03953326)
- 2026-02-27Also stopped (terminated): Penn State University, Acetylcholine + Sodium Nitroprusside (NCT03953326)
- 2026-02-20Also stopped (terminated): University Hospital, Lille, Formoterol-glycopyrronium co suspension (PT003) (NCT04087590)
- 2026-01-22Results posted on the registry: University of Utah, glycopyrronium cloths + Placebo (NCT04924036)
- 2025-12-22Also stopped (terminated): Jiangsu HengRui Medicine Co., Ltd., HRG2005 inhalation + Placebo to match HRG2005 inhalation (NCT06035393)
- 2025-10-14Phase 3 first posted: Miriam Freimer, Zilucoplan® (NCT07215949)
- 2025-09-19Results posted on the registry: AstraZeneca, BGF MDI HFO 320/14.4/9.6 μg + BGF MDI HFA 320/14.4/9.6 μg (NCT05573464)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision