Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:16 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy
NCT03225924 · The Lymphoma Academic Research Organisation · PHASE1/PHASE2 · terminated · last registry update 2020-09-02 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Stop of drug development” | – | Registry record, The Lymphoma Academic Research Organisation |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against SYK within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2021-08-31Phase 3 first posted: Hutchmed, HMPL-523 + Placebo (NCT05029635)
- 2021-08-25Phase 3 first posted: Kronos Bio, Entospletinib + Placebo (NCT05020665)
- 2021-06-14Phase 3 first posted: Sean Collins, TXA127 + TRV027 (NCT04924660)
- 2020-11-19Also stopped (terminated): Gilead Sciences, Entospletinib MM + Entospletinib SDD (NCT01799889)
- 2020-11-16Phase 3 first posted: Rigel Pharmaceuticals, Fostamatinib + Placebo (NCT04629703)
- 2020-09-23Results posted on the registry: Gilead Sciences, Entospletinib MM + Entospletinib SDD (NCT01799889)
- 2020-06-02Results posted on the registry: Gilead Sciences, Entospletinib + Idelalisib (NCT01796470)
- 2020-06-02Also stopped (terminated): Gilead Sciences, Entospletinib + Idelalisib (NCT01796470)
- 2020-05-18Results posted on the registry: Gilead Sciences, Filgotinib + Lanraplenib (NCT03285711)
- 2020-04-08Results posted on the registry: Gilead Sciences, Lanraplenib + Filgotinib (NCT03134222)
- 2020-03-06Results posted on the registry: Gilead Sciences, Entospletinib + Daunorubicin (NCT03135028)
- 2020-03-06Also stopped (terminated): Gilead Sciences, Entospletinib + Daunorubicin (NCT03135028)
- 2020-02-28Results posted on the registry: Gilead Sciences, Tirabrutinib + Entospletinib (NCT02983617)
- 2020-01-22Results posted on the registry: Gilead Sciences, Lanraplenib + Filgotinib (NCT03100942)
- 2020-01-02Also stopped (terminated): Gilead Sciences, Entospletinib + Vincristine (NCT02404220)
- 2019-12-02Results posted on the registry: Gilead Sciences, Entospletinib + Vincristine (NCT02404220)
- 2019-11-15Results posted on the registry: Gilead Sciences, Entospletinib + Daunorubicin (NCT02343939)
- 2019-11-15Also stopped (terminated): Gilead Sciences, Entospletinib + Daunorubicin (NCT02343939)
- 2019-10-25Phase 3 first posted: Rigel Pharmaceuticals, Fostamatinib disodium (NCT04138927)
- 2019-10-25Results posted on the registry: Gilead Sciences, Lanraplenib. (NCT02959138)
- 2019-10-18Phase 3 first posted: Kissei Pharmaceutical Co., Ltd., R788 + Placebo (NCT04132050)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision