Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 00:17 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma
NCT03319537 · Memorial Sloan Kettering Cancer Center · PHASE1/PHASE2 · terminated · last registry update 2024-05-23 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Sponsor terminated study agreement” | – | Registry record, Memorial Sloan Kettering Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against UBA3 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-01-07Results posted on the registry: National Cancer Institute (NCI), Carboplatin + Paclitaxel (NCT04175912)
- 2024-09-05Results posted on the registry: Takeda, Azacitidine + Pevonedistat (NCT03814005)
- 2024-06-04Also stopped (terminated): Medical College of Wisconsin, Azacitidine + Venetoclax (NCT04172844)
- 2023-12-15Results posted on the registry: National Cancer Institute (NCI), Carboplatin + Paclitaxel (NCT03965689)
- 2023-11-21Results posted on the registry: Vanderbilt-Ingram Cancer Center, Azacitidine Subcutaneous Injection or Intravenous Infusion + Pevonedistat Infusion (NCT03238248)
- 2023-11-03Results posted on the registry: Millennium Pharmaceuticals, Inc., Pevonedistat 25 mg/m^2 + Pevonedistat 44 mg/m^2 (NCT02782468)
- 2023-10-23Results posted on the registry: University of Michigan Rogel Cancer Center, Pevonedistat + Docetaxel (NCT03228186)
- 2023-10-23Also stopped (terminated): University of Michigan Rogel Cancer Center, Pevonedistat + Docetaxel (NCT03228186)
- 2023-09-18Results posted on the registry: Takeda, Pevonedistat + Venetoclax (NCT04266795)
- 2023-09-06Results posted on the registry: National Cancer Institute (NCI), Ixazomib Citrate + Pevonedistat (NCT03770260)
- 2023-06-27Also stopped (withdrawn): National Cancer Institute (NCI), Azacitidine + Pevonedistat (NCT03745352)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision