Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 06:08 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 Diabetes
NCT03396484 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · PHASE2 · withdrawn · last registry update 2020-06-30 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Study not begun due to continued laboratory work on the feasibility of outcome measures.” | – | Registry record, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against ADRA2A within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2021-05-27Results posted on the registry: Orion Corporation, Orion Pharma, Levodopa + Carbidopa (NCT03055936)
- 2021-05-27Also stopped (terminated): Shire, FST-201 (dexamethasone 0.1%) Otic Suspension + ciprofloxacin 0.3%, dexamethasone 0.1% (NCT00945802)
- 2021-05-05Also stopped (terminated): Vanderbilt University, Pseudoephedrine + 480 ml water + Pseudoephedrine + 50 ml water (NCT02149901)
- 2021-04-26Results posted on the registry: USWM, LLC (dba US WorldMeds), Lofexidine (NCT02363998)
- 2021-02-16Results posted on the registry: Actavis Inc., Nepafenac 0.3% Oph Susp + Placebos (NCT03499873)
- 2021-02-04Results posted on the registry: USWM, LLC (dba US WorldMeds), Lofexidine HCl + Placebo (NCT01863186)
- 2020-12-10Results posted on the registry: University of Texas Southwestern Medical Center, a drug against ADRA2A (NCT02347631)
- 2020-11-03Phase 3 first posted: Ataturk University, ondansetron + Granisetron (NCT04613726)
- 2020-10-27Results posted on the registry: Bausch & Lomb Incorporated, Ketotifen/naphazoline + Ketotifen (NCT00769886)
- 2020-10-27Results posted on the registry: Bausch & Lomb Incorporated, Ketotifen/naphazoline + Naphazoline (NCT00770133)
- 2020-10-14Results posted on the registry: Duke University, Phenylephrine + Ephedrine (NCT02025426)
- 2020-10-14Also stopped (terminated): Duke University, Phenylephrine + Ephedrine (NCT02025426)
- 2020-08-20Phase 3 first posted: University of Alberta, 5-Hydroxytryptophan 100 MG + 5-Hydroxytryptophan (NCT04520178)
- 2020-08-18Results posted on the registry: AbbVie, Optimized antiparkinsonian treatment + Levodopa-Carbidopa Intestinal Gel (LCIG) (NCT02799381)
- 2020-08-12Results posted on the registry: Impel Pharmaceuticals, Placebo + L-dopa 35 mg (NCT03541356)
- 2020-06-30Phase 3 first posted: Alexandria University, a drug against ADRA2A (NCT04452448)
- 2020-05-08Phase 3 first posted: AbbVie, ABBV-951 + Placebo for Levodopa/Carbidopa (LD/CD) (NCT04380142)
- 2020-04-07Results posted on the registry: Alcon Research, a drug against ADRA2A (NCT03579433)
- 2020-03-27Phase 3 first posted: Johns Hopkins University, Lofexidine + Placebo (NCT04325659)
- 2020-03-25Results posted on the registry: Alcon Research, a drug against ADRA2A (NCT03757039)
- 2020-03-25Also stopped (terminated): Alcon Research, a drug against ADRA2A (NCT03757039)
- 2020-03-02Results posted on the registry: Actavis Inc., Test-Brinzolamide 1% Ophthalmic suspension + Reference-Brinzolamide 1% Ophthalmic suspension (NCT02512042)
- 2020-01-27Results posted on the registry: Vanderbilt University Medical Center, Droxidopa + Carbidopa (NCT03115827)
- 2020-01-09Also stopped (withdrawn): Second Affiliated Hospital of Wenzhou Medical University, carbidopa/levodopa and celecoxib + placebo1 and celecoxib (NCT04082715)
- 2020-01-09Results posted on the registry: Oregon Health and Science University, carbidopa (NCT01399905)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision