Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 06:52 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Therapy of the Skeletal Disease of Type 2 Diabetes With Denosumab
NCT03457818 · Mishaela Rubin · PHASE2 · terminated · last registry update 2024-07-03 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Due to enrollment difficulties compounded by the COVID pandemic.” | – | Registry record, Mishaela Rubin |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against TNFSF11 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-05-29Results posted on the registry: Alvotech Swiss AG, AVT03 + Denosumab (NCT05395091)
- 2025-05-15Results posted on the registry: Alvotech Swiss AG, AVT03 + Denosumab (NCT05876949)
- 2025-05-11Also stopped (withdrawn): Xentria, Inc., MAB-22 + Prolia® (NCT06504966)
- 2025-04-16Results posted on the registry: Redx Pharma Ltd, RXC004 + Nivolumab (NCT04907539)
- 2025-03-21Results posted on the registry: mAbxience Research S.L., MB09 (denosumab biosimilar) + EU-Prolia (NCT05338086)
- 2025-03-17Results posted on the registry: Redx Pharma Ltd, RXC004 + RXC004 (NCT04907851)
- 2025-02-27Results posted on the registry: Fresenius Kabi SwissBioSim GmbH, FKS518 + US-licensed Prolia (Amgen) (NCT04934072)
- 2025-02-03Phase 3 first posted: Mabwell (Shanghai) Bioscience Co., Ltd., 9MW0311 + Prolia® (NCT06804590)
- 2025-01-09Results posted on the registry: Samsung Bioepis Co., Ltd., SB16 (Proposed Denosumab Biosimilar) + Prolia® (Denosumab) (NCT04664959)
- 2025-01-03Results posted on the registry: mAbxience Research S.L., MB09 + US-sourced Xgeva (NCT05299073)
- 2024-12-13Results posted on the registry: University Hospital, Ghent, Alendronate Effervescent Oral Tablet (NCT04403698)
- 2024-10-24Results posted on the registry: Gedeon Richter Plc., RGB-14-P + Prolia® (NCT05087030)
- 2024-09-25Results posted on the registry: University Hospital, Ghent, denosumab + Placebo (NCT02771860)
- 2024-09-19Results posted on the registry: Susan L. Greenspan, denosumab + Placebo (NCT02753283)
- 2024-08-23Results posted on the registry: Alison Stopeck, Denosumab (NCT02613416)
- 2024-08-12Results posted on the registry: UNC Lineberger Comprehensive Cancer Center, Denosumab + Pembrolizumab (NCT03620019)
- 2024-07-25Results posted on the registry: Thomas Nickolas, MD MS, Denosumab Inj 60 mg/ml (NCT03960554)
- 2024-07-25Also stopped (terminated): Thomas Nickolas, MD MS, Denosumab Inj 60 mg/ml (NCT03960554)
- 2024-07-19Results posted on the registry: Amgen, Denosumab (NCT03164928)
- 2024-07-17Phase 3 first posted: Xentria, Inc., MAB-22 + Prolia® (NCT06504966)
- 2024-05-20Results posted on the registry: Amgen, Denosumab (NCT03301857)
- 2024-05-16Results posted on the registry: Celltrion, CT-P41 + US-licensed Prolia (NCT04757376)
- 2024-05-08Results posted on the registry: Columbia University, Alendronate + Zoledronic Acid (NCT03396315)
- 2024-04-25Results posted on the registry: ETOP IBCSG Partners Foundation, Denosumab (NCT02129699)
- 2024-04-18Results posted on the registry: Teva Pharmaceuticals USA, TVB-009 + Prolia® (NCT04729621)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision