Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 18:18 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance
NCT03574857 · University of Virginia · PHASE4 · terminated · last registry update 2021-02-16 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Low enrollment” | – | Registry record, University of Virginia |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against SLC12A3 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2022-01-20Phase 3 first posted: Hanmi Pharmaceutical Company Limited, HCP1904-3 + RLD2001-1 (NCT05199129)
- 2021-12-15Also stopped (withdrawn): University Hospital Tuebingen, Dapagliflozin (Forxiga®) + Hydrochlorothiazide 25 mg (NCT03423355)
- 2021-12-09Also stopped (withdrawn): VA Office of Research and Development, Diuretic initiation or augmentation (NCT04192110)
- 2021-11-08Phase 3 first posted: Brainfarma Industria Química e Farmacêutica S/A, fixed-dose of olmesartan 20mg/40 mg + indapamide 1,5 mg + Isolated drugs Olmesartan (20 mg or 40 mg) and Indapamide (1,5 mg) (NCT05110898)
- 2021-10-22Results posted on the registry: University of Maryland, Baltimore, Metolazone 60 minutes prior to furosemide + Metolazone concurrently with furosemide (NCT03746002)
- 2021-10-22Also stopped (terminated): University of Maryland, Baltimore, Metolazone 60 minutes prior to furosemide + Metolazone concurrently with furosemide (NCT03746002)
- 2021-08-30Also stopped (withdrawn): Ramona Gelzer Bell, IV Diuretics (NCT04572867)
- 2021-07-07Phase 3 first posted: Second Affiliated Hospital, Zhejiang University, School of Medicine, Enalapril Folic Acid Tablets Combined With amlodipine + Enalapril Folic Acid Tablets Combined With hydrochlorothiazide (NCT04952051)
- 2021-06-15Phase 3 first posted: Laboratorios Silanes S.A. de C.V., Losartan/Chlorthalidone in fixed dose + Losartan + hydrochlorothiazide in fixed dose (NCT04927299)
- 2021-06-07Results posted on the registry: Novartis, Aliskiren + Amlodipine (NCT00667719)
- 2021-05-28Phase 3 first posted: University of Turin, Italy, a drug against SLC12A3 (NCT04907123)
- 2021-05-25Also stopped (terminated): The George Institute, telmisartan 20 mg + amlodipine 2.5mg + indapamide 1.25mg + Placebo oral capsule (NCT03783754)
- 2021-04-26Phase 3 first posted: NHS Greater Glasgow and Clyde, Dapagliflozin 10 MG Oral Tablet + Metolazone Tablets (NCT04860011)
- 2021-04-05Phase 3 first posted: Hanmi Pharmaceutical Company Limited, HCP1904-2 + RLD2001-2 (NCT04830449)
- 2021-04-01Also stopped (terminated): The George Institute, telmisartan 20mg + amlodipine 2.5mg +indapamide 1.25mg + Placebo oral capsule (NCT03785067)
- 2021-03-29Phase 3 first posted: Hanmi Pharmaceutical Company Limited, HCP1904-1 + RLD2001-1 (NCT04820907)
- 2021-02-24Also stopped (withdrawn): EMS, LENINGRADO 5 association + Natrilix® SR (NCT03814148)
- 2021-02-04Also stopped (withdrawn): Cedars-Sinai Medical Center, Thiazide Treatment Group + Intensified Thiazide Treatment Group (NCT03319823)
- 2021-01-05Results posted on the registry: University of Rochester, Chlorthalidone (NCT03325114)
- 2021-01-05Also stopped (terminated): University of Rochester, Chlorthalidone (NCT03325114)
- 2020-12-04Results posted on the registry: University of California, San Diego, Guanfacine + Hydrochlorothiazide (NCT02699125)
- 2020-12-01Results posted on the registry: Anderson Orthopaedic Research Institute, a drug against SLC12A3 (NCT02508428)
- 2020-10-19Results posted on the registry: University of California, San Diego, Nebivolol + Hydrochlorothiazide (NCT02710071)
- 2020-09-14Results posted on the registry: Hospital Civil de Guadalajara, Furosemide intravenous solution + Chlortalidone (NCT04393493)
- 2020-09-03Also stopped (withdrawn): The University of The West Indies, Losartan 50Mg Tab + Losartan/Hydrochlorothiazide 50 Mg-12.5 Mg ORAL TABLET (NCT03978884)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision