Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 18:02 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia
NCT03576885 · AdventHealth · PHASE1/PHASE2 · terminated · last registry update 2025-01-15 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “based on DSMB recommendation at interim analysis” | – | Registry record, AdventHealth |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against GUCY1B1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-12-30Also stopped (terminated): Beth Israel Deaconess Medical Center, Sodium Nitroprusside + 5% Dextrose solution (NCT04986072)
- 2025-12-19Results posted on the registry: Merck Sharp & Dohme LLC, Vericiguat + Placebo (NCT05093933)
- 2025-12-10Results posted on the registry: Beth Israel Deaconess Medical Center, Sodium Nitroprusside + 5% Dextrose solution (NCT04986072)
- 2025-12-02Also stopped (withdrawn): Massachusetts General Hospital, Nitrogen Gas for Inhalation + Nitric Oxide (NCT04022161)
- 2025-12-02Also stopped (withdrawn): Massachusetts General Hospital, Nitric Oxide (NCT03748082)
- 2025-11-26Phase 3 first posted: Beijing Tiantan Hospital, Isosorbide Mononitrate + Butylphthalide (NCT07252544)
- 2025-10-08Results posted on the registry: Josef Stehlik, Vericiguat + Placebo (NCT05420012)
- 2025-10-02Results posted on the registry: University of Delaware, MitoTempol + Lactated Ringer's (control) (NCT06466655)
- 2025-09-25Results posted on the registry: Sanotize Research and Development corp., Nitric Oxide (NCT05109611)
- 2025-09-25Also stopped (terminated): Sanotize Research and Development corp., Nitric Oxide (NCT05109611)
- 2025-09-25Results posted on the registry: Bayer, Vericiguat (BAY1021189) 5 mg (NCT06195930)
- 2025-09-17Also stopped (withdrawn): Ruijin Hospital, Oral isosorbide mononitrate 4+ amlodipine (NCT06730945)
- 2025-08-20Also stopped (terminated): Montefiore Medical Center, a drug against GUCY1B1 (NCT03026101)
- 2025-08-03Also stopped (terminated): Queen Mary University of London, a drug against GUCY1B1 (NCT03511248)
- 2025-07-15Results posted on the registry: Thirty Respiratory Limited, RESP301 + HRZE (NCT06041919)
- 2025-07-15Also stopped (terminated): Thirty Respiratory Limited, RESP301 + HRZE (NCT06041919)
- 2025-06-08Results posted on the registry: Western Sydney Local Health District, a drug against GUCY1B1 (NCT05401409)
- 2025-06-03Phase 3 first posted: Kardigan, Inc., Ataciguat + Placebo (NCT07001800)
- 2025-05-25Phase 3 first posted: Asklepion Pharmaceuticals, LLC, L-citrulline (NCT06989567)
- 2025-05-11Results posted on the registry: Peng Roc Chen, MD, Nicardipine + Verapamil (NCT01996436)
- 2025-05-11Also stopped (terminated): Peng Roc Chen, MD, Nicardipine + Verapamil (NCT01996436)
- 2025-05-04Results posted on the registry: Lacy Alexander, a drug against GUCY1B1 (NCT03376555)
- 2025-04-30Results posted on the registry: University of Cincinnati, Inhaled Nitric Oxide + Placebo (NCT03260569)
- 2025-04-23Results posted on the registry: Vicore Pharma AB, C21 + Sodium Nitroprusside (NCT05277922)
- 2025-04-10Phase 3 first posted: Suqiao Yang, Riociguat + Routine Treatment (NCT06922240)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision