Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:10 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma
NCT03646123 · Seagen Inc. · PHASE2 · terminated · last registry update 2025-08-28 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study was prematurely discontinued as the sponsor believes the data collected is enough to show the safety and efficacy of the combinations studied in all cohorts. The decision was not based on any safety and/or efficacy concerns.” | – | Registry record, Seagen Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against TUBB4B within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-08-18Results posted on the registry: Hoffmann-La Roche, Glofitamab + Tocilizumab (NCT04980222)
- 2026-08-11Results posted on the registry: Wake Forest University Health Sciences, Cyclophosphamide + Doxorubicin Hydrochloride (NCT03505762)
- 2026-08-04Results posted on the registry: Mirati Therapeutics Inc., Sitravatinib + Nivolumab (NCT04887870)
- 2026-08-03Results posted on the registry: Hoffmann-La Roche, Atezolizumab + Enfortumab Vedotin (NCT03869190)
- 2026-08-03Also stopped (terminated): Hoffmann-La Roche, Atezolizumab + Enfortumab Vedotin (NCT03869190)
- 2026-07-30Also stopped (terminated): M.D. Anderson Cancer Center, Cyclophosphamide + Cytarabine (NCT03488225)
- 2026-07-24Phase 3 first posted: National Cancer Institute (NCI), Carboplatin + Cyclophosphamide (NCT07724457)
- 2026-07-22Phase 3 first posted: AstraZeneca, Dato-DXd + Rilvegostomig (NCT07720284)
- 2026-07-22Phase 3 first posted: Ruijin Hospital, Orelabrutinib + obinutuzumab (NCT07719855)
- 2026-07-21Results posted on the registry: University Hospitals Bristol and Weston NHS Foundation Trust, Cabazitaxel + Paclitaxel (NCT03048942)
- 2026-07-17Phase 3 first posted: Dizal Pharmaceuticals, Birelentinib + Rituximab (NCT07712588)
- 2026-06-30Results posted on the registry: Merck Sharp & Dohme LLC, Pembrolizumab + Enfortumab Vedotin (NCT03924895)
- 2026-06-29Results posted on the registry: St. Jude Children's Research Hospital, vincristine + topotecan (NCT01783535)
- 2026-06-08Phase 3 first posted: Merck Sharp & Dohme LLC, MK-1045 + Rituximab (NCT07634471)
- 2026-05-28Phase 3 first posted: AstraZeneca, Actinium (225Ac) zadavotide guraxetan (AZD2265 [FPI-2265]) + Cabazitaxel (NCT07611110)
- 2026-05-04Phase 3 first posted: Astellas Pharma Global Development, Inc., Enfortumab vedotin + Cisplatin (NCT07566156)
- 2026-04-13Results posted on the registry: Astellas Pharma Global Development, Inc., enfortumab vedotin + pembrolizumab (NCT04225117)
- 2026-04-02Results posted on the registry: National Cancer Institute (NCI), Cyclophosphamide + Doxorubicin Hydrochloride (NCT03220022)
- 2026-03-12Phase 3 first posted: Children's Oncology Group, Cyclophosphamide + Dactinomycin (NCT07466316)
- 2026-03-06Results posted on the registry: Hoffmann-La Roche, Mosunetuzumab + Polatuzumab vedotin (NCT05171647)
- 2026-02-25Results posted on the registry: ECOG-ACRIN Cancer Research Group, Venetoclax + Vincristine Liposomal (NCT03504644)
- 2026-02-19Phase 3 first posted: Merck Sharp & Dohme LLC, Sacituzumab tirumotecan + Vinflunine (NCT07419295)
- 2026-02-04Results posted on the registry: AstraZeneca, Dato-DXd + Capecitabine (NCT05104866)
- 2026-01-29Results posted on the registry: University of Wisconsin, Madison, Rituximab + Cyclophosphamide (NCT03943901)
- 2026-01-16Phase 3 first posted: Guliz Ozgun, enfortumab vedotin and pembrolizumab (EV/P) (NCT07346053)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision