Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:55 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Comparative Multicenter Randomized Study of Aflibercept Versus Placebo in Macular Telangiectasia Type 1
NCT03845049 · Centre Hospitalier Universitaire Dijon · PHASE3 · terminated · last registry update 2026-01-26 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “very rare disease, many difficulties in recruiting patients, inclusion rate far too slow, making it impossible to meet the main objective within a reasonable timeframe. the sponsor therefore decided to stop the study.” | – | Registry record, Centre Hospitalier Universitaire Dijon |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against VEGFA within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-11-06Phase 3 first posted: University of Illinois Chicago, Faricimab Injection for stage 3 or stage 4 Proliferative sickle cell eyes (NCT07922460)
- 2026-11-03Results posted on the registry: Bayer, Aflibercept (BAY86-5321, Eylea) (NCT06591598)
- 2026-10-20Results posted on the registry: Massachusetts Eye and Ear Infirmary, Sub-tenon injection of saline followed by a sub-tenon injection of aflibercept + Sub-tenon injection of hyaluronidase (HA) followed by a sub-tenon injection of aflibercept (NCT04311606)
- 2026-10-20Also stopped (terminated): Massachusetts Eye and Ear Infirmary, Sub-tenon injection of saline followed by a sub-tenon injection of aflibercept + Sub-tenon injection of hyaluronidase (HA) followed by a sub-tenon injection of aflibercept (NCT04311606)
- 2026-10-09Phase 3 first posted: 4D Molecular Therapeutics, 4D-150 IVT (3x10^10 vg) + EYELEA ® (aflibercept) Injection 2 mg (0.05mL) (NCT07867080)
- 2026-10-05Results posted on the registry: Centre Hospitalier Intercommunal Creteil, Aflibercept (NCT02157077)
- 2026-09-28Phase 3 first posted: AO GENERIUM, aflibercept + Eylea (NCT07844148)
- 2026-09-25Phase 3 first posted: Ollin Biosciences, Inc., OLN324 + Aflibercept (NCT07841899)
- 2026-09-25Phase 3 first posted: Ollin Biosciences, Inc., OLN324 + Aflibercept (NCT07842016)
- 2026-09-18Results posted on the registry: Regeneron Pharmaceuticals, Aflibercept 8 mg (NCT06491914)
- 2026-09-11Phase 3 first posted: Ollin Biosciences, Inc., OLN324 + Aflibercept (NCT07816315)
- 2026-09-11Phase 3 first posted: Ollin Biosciences, Inc., OLN324 + Ranibizumab (NCT07816289)
- 2026-08-03Results posted on the registry: Outlook Therapeutics, Inc., bevacizumab + ranibizumab (NCT03834753)
- 2026-08-03Results posted on the registry: Mylan Pharmaceuticals Inc, MYL-1701P, a proposed biosimilar to Eylea (NCT04674800)
- 2026-07-29Phase 3 first posted: Kodiak Sciences Inc, Tabirafusp tedromer + Aflibercept (2.0 mg) (NCT07734844)
- 2026-07-29Results posted on the registry: The Cleveland Clinic, Dexamethasone implant + Aflibercept (NCT04411693)
- 2026-07-15Phase 3 first posted: Merck Sharp & Dohme LLC, MK-8748 + Aflibercept (NCT07705555)
- 2026-07-15Phase 3 first posted: Merck Sharp & Dohme LLC, MK-8748 + Aflibercept (NCT07705607)
- 2026-07-10Phase 3 first posted: SANGMYUNG innovation, SMZ1 + SMZ1 Placebo (NCT07695207)
- 2026-06-30Results posted on the registry: Outlook Therapeutics, Inc., bevacizumab + ranibizumab (NCT06190093)
- 2026-05-29Phase 3 first posted: Amgen, ABP 938 8 mg + Aflibercept (US) 8 mg (NCT07614776)
- 2026-05-28Results posted on the registry: Regeneron Pharmaceuticals, aflibercept 8 mg PFS (NCT05989126)
- 2026-05-26Results posted on the registry: Laboratorios Sophia S.A de C.V., Bevacizumab + Lucentis® (NCT05217680)
- 2026-05-11Results posted on the registry: Hoffmann-La Roche, Vamikibart + Ranibizumab (NCT05151731)
- 2026-04-09Phase 3 first posted: Shenzhen Oculgen Biomedical Technology Co., Ltd., bispecific anti-VEGF and anti-complement (NCT07520318)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision