Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 21:23 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Dose Escalation and Expansion Study of TRX518 in Combination With Cyclophosphamide Plus Avelumab in Advanced Solid Tumors
NCT03861403 · Leap Therapeutics, Inc. · PHASE1 · terminated · last registry update 2023-11-30 · Breast cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Product development discontinued unrelated to safety.” | – | Registry record, Leap Therapeutics, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CD274 in breast cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2024-06-18Results posted on the registry: National Cancer Institute (NCI), Atezolizumab + Carboplatin (NCT02883062)
- 2023-12-12Results posted on the registry: Dana-Farber Cancer Institute, Palbociclib + Fulvestrant (NCT03147287)
- 2023-11-18Phase 3 first posted: Tokyo Medical and Dental University, Systemic therapy for 12 weeks after primary registration + Same systemic therapy after secondary registration (NCT06135714)
- 2023-11-01Phase 3 first posted: AstraZeneca, Dato-DXd + Durvalumab (NCT06112379)
- 2023-10-27Phase 3 first posted: AstraZeneca, Dato-DXd + Durvalumab (NCT06103864)
- 2023-09-28Phase 3 first posted: National Cancer Institute (NCI), Cyclophosphamide + Doxorubicin (NCT06058377)
- 2023-03-21Results posted on the registry: City of Hope Medical Center, Atezolizumab + Capecitabine (NCT03853707)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision