Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 04:13 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Acute Effects of the Prostaglandin (Alprostadil) on Cerebral and Pulmonary Flow
NCT04054115 · The Hospital for Sick Children · PHASE1 · terminated · last registry update 2023-02-08 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Covid 19 and difficulty with recruitment” | – | Registry record, The Hospital for Sick Children |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against PTGER1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2023-09-15Also stopped (withdrawn): Alonso Vera Torres, Analogs, Prostaglandin E1 + Standard therapeutic protocol (NCT04536363)
- 2023-09-15Also stopped (suspended): Guangzhou Women and Children's Medical Center, Induction of labor with PGE2 (NCT04780269)
- 2023-08-30Results posted on the registry: Ruth M. Rothstein CORE Center, Lubiprostone (NCT01839734)
- 2023-06-01Results posted on the registry: Henry Ford Health System, lubiprostone (Amitiza) + Placebo (NCT00645801)
- 2023-05-15Also stopped (terminated): University Hospital, Toulouse, Balloon catheter + oral misoprostol + Oral misoprostol alone (NCT03435458)
- 2023-03-17Phase 3 first posted: Hospital Universitario 12 de Octubre, Vaginal dinoprostone (NCT05774236)
- 2023-03-14Phase 3 first posted: Helwan University, Lubiprostone 24Mcg Oral twice daily (NCT05768334)
- 2023-03-09Phase 3 first posted: Beni-Suef University, Dinoprostone + Misoprostol (NCT05761418)
- 2022-11-14Also stopped (terminated): South Warwickshire NHS Foundation Trust, 10 mg Dinoprostone; CTS, UK + 3 mg Dinoprostone vaginal tablet; Pfizer, UK (NCT02956785)
- 2022-03-02Results posted on the registry: Medstar Health Research Institute, Mifepristone + Misoprostol (NCT02412618)
- 2022-03-02Also stopped (terminated): Baycrest, a drug against PTGER1 (NCT04184037)
- 2022-02-21Also stopped (withdrawn): London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's, a drug against PTGER1 (NCT04654130)
- 2022-02-09Also stopped (terminated): Thomas Staudinger, Alprostadil + 0.9% sodium chloride solution (NCT02895373)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision