Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:54 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Efficacy, Safety and Tolerability of the Combination of Tropifexor & Licogliflozin and Each Monotherapy, Compared With Placebo in Adult Patients With NASH and Liver Fibrosis.
NCT04065841 · Novartis Pharmaceuticals · PHASE2 · terminated · last registry update 2025-01-28 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The sponsor made a business decision to stop development of the trial drugs. The decision to stop the trial early was not because of any safety concerns.” | – | Registry record, Novartis Pharmaceuticals |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against NR1H4 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-12-22Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate + UDCA (Ursodeoxycholic acid) (NCT07296458)
- 2025-12-15Phase 3 first posted: Cascade Pharmaceuticals, Inc, 2mg CS0159 + Placebo (NCT07282353)
- 2025-11-26Results posted on the registry: Gilead Sciences, Semaglutide (SEMA) + Cilofexor (CILO)/Firsocostat (FIR) (NCT04971785)
- 2025-03-12Results posted on the registry: Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA), TERN-501 + TERN-101 (NCT05415722)
- 2025-02-25Results posted on the registry: Gilead Sciences, Placebo Comparator + Experimental: Seladelpar 50 mg (NCT02609048)
- 2025-02-25Also stopped (terminated): Gilead Sciences, Placebo Comparator + Experimental: Seladelpar 50 mg (NCT02609048)
- 2025-02-24Results posted on the registry: Capricor Inc., CAP-1002 + Placebo (NCT03406780)
- 2025-02-20Results posted on the registry: Capricor Inc., CAP-1002 + Placebo (NCT04623671)
- 2025-01-01Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate (NCT06755151)
- 2025-01-01Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate in Combination With Ursodeoxycholic Acid (NCT06755541)
- 2024-12-04Phase 3 first posted: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., OCA + UDCA (NCT06715319)
- 2024-11-18Also stopped (withdrawn): Leadiant Biosciences, Inc., Chenodeoxycholic acid + Chenodeoxycholic acid Placebo (NCT06260748)
- 2024-10-28Results posted on the registry: Mirum Pharmaceuticals, Inc., Blinded CDCA 250 mg TID + Placebo (NCT04270682)
- 2024-09-19Phase 3 first posted: Han Ying, Prednisone + UDCA (Ursodeoxycholic acid) (NCT06591468)
- 2024-09-05Results posted on the registry: Ipsen, Elafibranor 80mg + Placebo (NCT04526665)
- 2024-07-25Results posted on the registry: Gilead Sciences, Seladelpar 10 mg + Placebo (NCT04620733)
- 2024-07-16Results posted on the registry: University of Maryland, Baltimore, pravastatin and chenodeoxycholic acid, after metformin and placebo + valacyclovir, chenodeoxycholic acid, and enalaprilat, after polysorbate 80 and placebo (NCT04640571)
- 2024-07-05Phase 3 first posted: Intercept Pharmaceuticals, FDC tablet (OCA 5 mg + BZF 400 mg SR) (NCT06488911)
- 2024-06-05Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, Bezafibrate 400 mg in addition to UDCA therapy + Bezafibrate 200 mg in addition to UDCA therapy (NCT06443606)
- 2024-05-16Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Dapagliflozin (NCT06415773)
- 2024-04-25Phase 3 first posted: Ipsen, Elafibranor (NCT06383403)
- 2024-04-15Phase 3 first posted: Xijing Hospital of Digestive Diseases, Fenofibrate + UDCA (NCT06365424)
- 2024-04-09Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Placebo (NCT06353347)
- 2024-04-09Also stopped (terminated): Nottingham University Hospitals NHS Trust, Ursodeoxycholic acid (NCT05526807)
- 2024-04-08Phase 3 first posted: Shenzhen HighTide Biopharmaceutical Ltd., HTD1801 + Placebo (NCT06350890)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision