Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 06:04 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Mepolizumab in Episodic Angioedema With Eosinophilia
NCT04128371 · National Institute of Allergy and Infectious Diseases (NIAID) · PHASE2 · terminated · last registry update 2024-04-16 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Study was closed after the first five participants completed their participation due to lack of efficacy.” | – | Registry record, National Institute of Allergy and Infectious Diseases (NIAID) |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against IL5 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-01-14Results posted on the registry: AstraZeneca, Benralizumab + Mepolizumab (NCT04157348)
- 2024-12-17Results posted on the registry: GlaxoSmithKline, GSK3511294 (Depemokimab) + Placebo (NCT04719832)
- 2024-12-10Results posted on the registry: GlaxoSmithKline, Mepolizumab + Salbutamol (NCT04276233)
- 2024-11-29Results posted on the registry: GlaxoSmithKline, GSK3511294 + Placebo (NCT04718103)
- 2024-11-25Results posted on the registry: GlaxoSmithKline, Mepolizumab + Placebo (NCT04607005)
- 2024-11-20Also stopped (withdrawn): Mayo Clinic, Mepolizumab (NCT04305678)
- 2024-09-19Results posted on the registry: GlaxoSmithKline, Mepolizumab 100 milligrams + Placebo (NCT03562195)
- 2024-04-22Results posted on the registry: Food and Drug Administration (FDA), Mepolizumab + Mepolizumab (NCT04183192)
- 2024-03-12Results posted on the registry: GlaxoSmithKline, Mepolizumab + Prednisolone (NCT03298061)
- 2023-08-07Phase 3 first posted: Guangdong Hengrui Pharmaceutical Co., Ltd, SHR-1703 + Mepolizumab Injection (NCT05979051)
- 2023-06-23Results posted on the registry: University of North Carolina, Chapel Hill, Mepolizumab 300 mg + Mepolizumab 100 mg (NCT03656380)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision