Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 05:59 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Evaluating the Effects of Tradipitant vs. Placebo in Atopic Dermatitis (EPIONE2)
NCT04140695 · Vanda Pharmaceuticals · PHASE3 · terminated · last registry update 2024-05-14 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Business Decision” | – | Registry record, Vanda Pharmaceuticals |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against TACR1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-05-09Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT03772340)
- 2025-05-04Results posted on the registry: Helsinn Healthcare SA, Fosnetupitant 235 mg solution + Akynzeo solution (NCT06840769)
- 2025-05-04Also stopped (terminated): Helsinn Healthcare SA, Fosnetupitant 235 mg solution + Akynzeo solution (NCT06840769)
- 2025-05-01Phase 3 first posted: Jiuda Zhao, standard quadruple antiemetic therapy + standard quadruple antiemetic therapy (NCT06952920)
- 2025-04-17Phase 3 first posted: Qilu Pharmaceutical (Hainan) Co., Ltd., Aprepitant Injection + Aprepitant Injection Placebo (NCT06932107)
- 2025-04-04Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT05903924)
- 2025-02-27Also stopped (terminated): Insel Gruppe AG, University Hospital Bern, Aprepitant 80 mg + Placebo (NCT05189756)
- 2025-02-20Phase 3 first posted: Vanda Pharmaceuticals, Tradipitant (NCT06836557)
- 2024-12-11Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT04327661)
- 2024-10-24Results posted on the registry: Georgetown University, mFOLFIRINOX (NCT03885284)
- 2024-09-19Phase 3 first posted: Augusta University, Olanzapine (NCT06588413)
- 2024-08-30Also stopped (withdrawn): University of Nebraska, aprepitant (NCT01186029)
- 2024-08-09Phase 3 first posted: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd., Aprepitant Injection + Aprepitant Injection Placebo (NCT06543966)
- 2024-08-07Also stopped (withdrawn): Australasian Leukaemia and Lymphoma Group, Standard anti-emetics in conjunction with R-CHOP (NCT01843868)
- 2024-08-06Results posted on the registry: Vanda Pharmaceuticals, VLY-686 (Tradipitant) (NCT02970968)
- 2024-06-13Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT02651714)
- 2024-05-13Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT03568331)
- 2024-05-08Results posted on the registry: National Cancer Institute (NCI), TRC102 (NCT01851369)
- 2024-04-24Phase 3 first posted: Montefiore Medical Center, Fosaprepitant 150 mg + Ondansetron 4 mg (NCT06382012)
- 2024-04-16Results posted on the registry: Vanda Pharmaceuticals, Tradipitant + Placebo (NCT04849559)
- 2024-03-26Phase 3 first posted: Fudan University, Netupitant / Palonosetron Oral Capsule [Akynzeo] + Olanzapine (NCT06331520)
- 2024-03-19Phase 3 first posted: Lahore Medical Research Center, LLP, Ibuprofen and Aprepitant (NCT06317064)
- 2024-02-28Phase 3 first posted: The First Affiliated Hospital of Xinxiang Medical College, Ondansetron Oral Soluble Pellicles (NCT06282211)
- 2024-02-14Results posted on the registry: Stony Brook University, Aprepitant 80 mg Oral Capsule + scopolamine transdermal (NCT03435003)
- 2024-01-22Results posted on the registry: Rush University Medical Center, o Aprepitant 125 mg orally one hour prior to chemotherapy on Day -1 and 80 mg orally on Days 0 and +1 + Olanzapine10 mg orally daily on Days -1,0,+1 and +2 (NCT02939287)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision