Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 07:35 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate Cancer
NCT04227275 · Tceleron Therapeutics, Inc. · PHASE1 · terminated · last registry update 2023-08-21 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Based on the safety events and evidence of biologic activity without sustained clinical responses the Sponsor finds the risk/benefit analysis unfavorable for patients and has terminated the study.” | – | Registry record, Tceleron Therapeutics, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against IL1R1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2024-08-01Also stopped (terminated): University of Alabama at Birmingham, kineret + placebo (NCT02780583)
- 2024-05-24Results posted on the registry: Juno Therapeutics, a Subsidiary of Celgene, JCARH125 + JCARH125 + anakinra (NCT03430011)
- 2024-03-29Phase 3 first posted: Assistance Publique - Hôpitaux de Paris, ANAKINRA (NCT06336733)
- 2024-03-04Results posted on the registry: University of California, San Diego, Anakinra (NCT02179853)
- 2023-08-24Results posted on the registry: University of Alabama at Birmingham, Anakinra + Normal saline (NCT04362111)
- 2023-07-28Results posted on the registry: Indiana University, Anakinra and Zinc + Prednisone (NCT04072822)
- 2023-07-03Phase 3 first posted: Hellenic Institute for the Study of Sepsis, Placebo + Anakinra 149 MG/ML Prefilled Syringe [Kineret] (NCT05926505)
- 2023-04-14Phase 3 first posted: Swedish Orphan Biovitrum, Anakinra + Placebo (NCT05814159)
- 2023-04-10Phase 3 first posted: Istituto Giannina Gaslini, Anakinra + Prednisone (NCT05805930)
- 2023-03-14Results posted on the registry: University of Pennsylvania, Anakinra + Placebo (NCT03141983)
- 2023-03-14Results posted on the registry: University Hospital, Ghent, Anakinra + Siltuximab (NCT04330638)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision