Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:50 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
NCT04240002 · Astellas Pharma Global Development, Inc. · PHASE1/PHASE2 · terminated · last registry update 2026-01-05 · Acute myeloid leukemia · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study was terminated due to enrollment challenges.” | Open Targets' class: insufficient enrollment | Registry record, Astellas Pharma Global Development, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against FLT3 in acute myeloid leukemia within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-07-20Phase 3 first posted: The Second Affiliated Hospital of Kunming Medical University, a drug against FLT3 (NCT07712848)
- 2026-03-18Phase 3 first posted: PETHEMA Foundation, Azacitidine + Venetoclax (NCT07478991)
- 2026-03-18Results posted on the registry: Nerviano Medical Sciences, NMS-03592088 (NCT03922100)
- 2026-03-18Also stopped (terminated): Nerviano Medical Sciences, NMS-03592088 (NCT03922100)
- 2026-03-11Phase 3 first posted: The First Affiliated Hospital of Soochow University, Gilteritinib + Sorafenib (NCT07463651)
- 2026-02-23Phase 3 first posted: European Organisation for Research and Treatment of Cancer - EORTC, Gilteritinib + Venetoclax (NCT07425808)
- 2026-02-12Phase 3 first posted: Institute of Hematology & Blood Diseases Hospital, China, Gilteritinib + Azacitidine + Venetoclax + Cytarabine + Daunorubicin (or Idarubicin) + Gilteritinib (NCT07407140)
- 2025-12-04Phase 3 first posted: Nanfang Hospital, Southern Medical University, Sorafenib (SORA) + Venetoclax (VEN) (NCT07264010)
- 2025-11-05Results posted on the registry: University of Nebraska, Cytarabine + Decitabine (NCT03226418)
- 2025-09-12Results posted on the registry: Astellas Pharma Global Development, Inc., gilteritinib + azacitidine (NCT02752035)
- 2025-05-15Phase 3 first posted: Ruijin Hospital, Decitabine + Sorafenib (BAY-43-9006),giritinib (NCT06972641)
- 2025-03-07Also stopped (terminated): Aptose Biosciences Inc., CG-806 (NCT04477291)
- 2025-02-28Results posted on the registry: PrECOG, LLC., Gilteritinib + Midostaurin (NCT03836209)
- 2025-02-25Also stopped (terminated): Niguarda Hospital, Midostaurin (NCT03686345)
- 2025-02-11Results posted on the registry: Novartis Pharmaceuticals, Midostaurin + Placebo (NCT03280030)
- 2025-01-14Results posted on the registry: Astellas Pharma Inc, Gilteritinib + Cytarabine (NCT03182244)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision