Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:08 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Aromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Cancer With an ERS1 Activating Mutation, the INTERACT Study
NCT04256941 · M.D. Anderson Cancer Center · PHASE2 · terminated · last registry update 2024-12-27 · Breast cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Despite modifications, accrual was poor and the closed” | – | Registry record, M.D. Anderson Cancer Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CDK4 in breast cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-11-28Also stopped (terminated): Blueprint Medicines Corporation, BLU-222 + Carboplatin (NCT05252416)
- 2025-11-24Results posted on the registry: Sanofi, Amcenestrant + Palbociclib (NCT03284957)
- 2025-11-24Also stopped (terminated): Sanofi, Amcenestrant + Palbociclib (NCT03284957)
- 2025-11-21Phase 3 first posted: Women's Cancer Study Group GmbH, Elacestrant + Standard-of-care endocrine treatment (NCT07242352)
- 2025-11-19Phase 3 first posted: UNICANCER, Chemotherapy followed by endocrine therapy and ribociclib treatment (NCT07237256)
- 2025-11-10Results posted on the registry: Hoffmann-La Roche, Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (PD-L1) antibody + Bevacizumab (NCT03280563)
- 2025-09-24Phase 3 first posted: Japanese Foundation for Cancer Research, Endocrine therapy + Abemaciclib + Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen (NCT07190443)
- 2025-09-15Phase 3 first posted: Eli Lilly and Company, LY4064809 + Placebo (NCT07174336)
- 2025-09-11Also stopped (terminated): Sanofi, Amcenestrant-matching placebo + SAR439859 (NCT04478266)
- 2025-07-29Also stopped (terminated): University of Milano Bicocca, Abemaciclib + Aromatase Inhibitors (NCT04227327)
- 2025-07-25Phase 3 first posted: Olema Pharmaceuticals, Inc., Palazestrant + Letrozole-matching placebo (NCT07085767)
- 2025-07-15Results posted on the registry: Eli Lilly and Company, Abemaciclib + Standard Adjuvant ET (NCT04752332)
- 2025-07-15Also stopped (terminated): Eli Lilly and Company, Abemaciclib + Standard Adjuvant ET (NCT04752332)
- 2025-07-11Results posted on the registry: Eli Lilly and Company, Imlunestrant + Exemestane (NCT04975308)
- 2025-07-11Phase 3 first posted: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Palbociclib 125mg qd (3 weeks of treatment followed by 1 week off) + Anastrozole 1mg qd / Letrozole 2.5mg qd / Exemestane 25mg qd + Palbociclib 125mg qd (3 weeks of treatment followed by 1 week off) + Anastrozole 1mg qd / Letrozole 2.5mg qd / Exemestane 25mg qd + Hydroxychloroquine 600mg bid (NCT07061717)
- 2025-06-24Results posted on the registry: Boehringer Ingelheim, Xentuzumab + Abemaciclib (NCT03099174)
- 2025-06-05Phase 3 first posted: Fudan University, Chemotherapy + CDK4/6 Inhibitor (NCT07005557)
- 2025-05-31Also stopped (terminated): Dana-Farber Cancer Institute, Ribociclib + PDR001 (NCT03294694)
- 2025-05-30Phase 3 first posted: Fudan University, 4 cycles of TC (docetaxel + cyclophosphamide) adjuvant chemotherapy + aromatase inhibitor (± ovarian suppression) plus CDK4/6 inhibitor (NCT06996093)
- 2025-03-24Results posted on the registry: Fundacion Oncosur, Combination, Palbociclib + Binimetinib (NCT04494958)
- 2025-02-27Results posted on the registry: Eli Lilly and Company, Abemaciclib + Fulvestrant (NCT05169567)
- 2025-01-07Phase 3 first posted: Pfizer, PF-07220060 + letrozole (NCT06760637)
- 2025-01-03Phase 3 first posted: Celcuity Inc, Arm A: Gedatolisib + Palbociclib + Fulvestrant + Arm B: Ribociclib + Fulvestrant (NCT06757634)
- 2024-12-13Results posted on the registry: ETOP IBCSG Partners Foundation, Paclitaxel + Trastuzumab (NCT03644186)
- 2024-10-09Results posted on the registry: Hoffmann-La Roche, Inavolisib + Placebo (NCT04191499)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision