Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:13 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Dual-Orexin Antagonism As a Mechanism for Improving Sleep and Drug Abstinence in Opioid Use Disorder
NCT04262193 · Wayne State University · PHASE2 · terminated · last registry update 2024-09-25 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Did not meet enrollment goals.” | – | Registry record, Wayne State University |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against HCRTR2 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-07-11Results posted on the registry: University of Rochester, Daridorexant 50 mg (NCT06630390)
- 2025-07-03Results posted on the registry: Eisai Co., Ltd., Lemborexant (NCT05594589)
- 2025-06-19Phase 3 first posted: Nxera Pharma Korea Co., Ltd., Daridorexant + Placebo (NCT07028697)
- 2025-06-04Results posted on the registry: Janssen Research & Development, LLC, Seltorexant + Placebo (NCT04532749)
- 2025-06-04Also stopped (terminated): Janssen Research & Development, LLC, Seltorexant + Placebo (NCT04532749)
- 2025-05-01Also stopped (withdrawn): Mayo Clinic, Suvorexant (NCT06834386)
- 2025-04-29Results posted on the registry: The University of Texas Health Science Center, Houston, suvorexant (SUVO) + Placebo (NCT05711862)
- 2025-04-29Also stopped (terminated): The University of Texas Health Science Center, Houston, suvorexant (SUVO) + Placebo (NCT05711862)
- 2025-04-27Also stopped (terminated): Janssen Research & Development, LLC, Seltorexant + Placebo (NCT04951609)
- 2025-04-18Results posted on the registry: Idorsia Pharmaceuticals Ltd., Daridorexant + Placebo (NCT05597020)
- 2025-02-03Results posted on the registry: Theodore R. Brown, MD MPH, Suvorexant + Placebo (NCT03110315)
- 2024-12-20Results posted on the registry: Eisai Co., Ltd., Lemborexant + Placebo (NCT04549168)
- 2024-11-25Results posted on the registry: Janssen Research & Development, LLC, Seltorexant + Placebo (NCT05307692)
- 2024-11-13Results posted on the registry: Virginia Commonwealth University, Lemborexant + Placebo (NCT04818086)
- 2024-10-24Phase 3 first posted: Merck Sharp & Dohme LLC, Suvorexant + Placebo (NCT06655883)
- 2024-08-20Results posted on the registry: Burdick, Daniel, M.D., Suvorexant + Placebo (NCT02729714)
- 2024-08-19Phase 3 first posted: Janssen Research & Development, LLC, Seltorexant + Placebo (NCT06559306)
- 2024-07-11Phase 3 first posted: Phramongkutklao College of Medicine and Hospital, Lemborexant + Placebo (NCT06496282)
- 2024-05-20Results posted on the registry: Merck Sharp & Dohme LLC, Suvorexant + Placebo (NCT04571944)
- 2024-02-16Phase 3 first posted: University of Manitoba, Lemborexant + Placebo (NCT06262594)
- 2024-02-12Results posted on the registry: Milton S. Hershey Medical Center, Suvorexant 20 mg (NCT03412591)
- 2024-01-16Results posted on the registry: Massachusetts General Hospital, Suvorexant (NCT04706091)
- 2023-11-08Also stopped (withdrawn): Brendan Lucey, Lemborexant 25 mg + Placebo (NCT05728736)
- 2023-10-10Results posted on the registry: Eisai Inc., Placebo + Lemborexant 10 mg (NCT04647383)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision