Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:37 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Study of Capmatinib Efficacy in Comparison With Docetaxel in Previously Treated Participants With Non-small Cell Lung Cancer Harboring MET Exon 14 Skipping Mutation
NCT04427072 · Novartis Pharmaceuticals · PHASE3 · terminated · last registry update 2025-05-16 · Non-small cell lung cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Company decision not related to any safety concerns.” | Open Targets' class: business administrative | Registry record, Novartis Pharmaceuticals |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against MET in non-small cell lung cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-04-23Also stopped (terminated): National Cancer Institute (NCI), Alectinib + Brigatinib (NCT03737994)
- 2026-03-27Results posted on the registry: Novartis Pharmaceuticals, Capmatinib (NCT04677595)
- 2026-02-02Results posted on the registry: Janssen Research & Development, LLC, Lazertinib + Amivantamab Subcutaneous and Co-Formulated with Recombinant Human Hyaluronidase (SC CF) (NCT05388669)
- 2026-01-13Results posted on the registry: Exelixis, XL184 + erlotinib (NCT00596648)
- 2025-10-24Results posted on the registry: AbbVie, Telisotuzumab Vedotin (NCT05513703)
- 2025-10-24Also stopped (terminated): AbbVie, Telisotuzumab Vedotin (NCT05513703)
- 2025-10-20Results posted on the registry: Janssen Research & Development, LLC, Dexamethasone + Montelukast (NCT05663866)
- 2025-10-16Also stopped (terminated): Novartis Pharmaceuticals, capmatinib (NCT04926831)
- 2025-04-16Results posted on the registry: Janssen Research & Development, LLC, Lazertinib + Amivantamab (NCT04988295)
- 2025-04-03Phase 3 first posted: Intergroupe Francophone de Cancerologie Thoracique, Tepotinib + Pemetrexed (Alimta) (NCT06908993)
- 2025-03-26Results posted on the registry: Novartis Pharmaceuticals, capmatinib (NCT04926831)
- 2025-02-19Results posted on the registry: Takeda, Brigatinib + Alectinib (NCT03596866)
- 2025-02-10Also stopped (terminated): Blueprint Medicines Corporation, BLU-451 + Carboplatin (NCT05241873)
- 2024-11-08Results posted on the registry: Pfizer, Crizotinib (NCT03672643)
- 2024-11-08Also stopped (terminated): Pfizer, Crizotinib (NCT03672643)
- 2024-10-09Results posted on the registry: Janssen Research & Development, LLC, Amivantamab + Osimertinib (NCT04487080)
- 2024-10-09Also stopped (terminated): Novartis Pharmaceuticals, Capmatinib + Pembrolizumab (NCT04139317)
- 2024-10-09Also stopped (terminated): Novartis Pharmaceuticals, Spartalizumab + Capmatinib (NCT04323436)
- 2024-09-24Results posted on the registry: AstraZeneca, Osimertinib + Savolitinib + Savolitinib + Placebo (NCT04606771)
- 2024-08-26Phase 3 first posted: Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd., a drug against MET (NCT06569420)
- 2024-08-21Phase 3 first posted: Nuvation Bio Inc., Taletrectinib + Crizotinib (NCT06564324)
- 2024-06-26Also stopped (withdrawn): AbbVie, Telisotuzumab Vedotin + Osimertinib (NCT06093503)
- 2024-06-17Also stopped (withdrawn): Timothy Burns, MD, PHD, Capmatinib (NCT05567055)
- 2024-06-11Also stopped (terminated): Collin Blakely, Capmatinib + Trametinib (NCT05435846)
- 2024-06-04Results posted on the registry: EMD Serono Research & Development Institute, Inc., Tepotinib + Osimertinib (NCT03940703)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision