Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 02:06 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Evaluate Guselkumab for the Treatment of Participants With New-onset or Relapsing Giant Cell Arteritis
NCT04633447 · Janssen Research & Development, LLC · PHASE2 · terminated · last registry update 2025-07-01 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The study primary endpoint was not met” | – | Registry record, Janssen Research & Development, LLC |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against IL12B within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-06-24Results posted on the registry: Janssen Research & Development, LLC, Guselkumab + Placebo (NCT05272150)
- 2026-06-23Results posted on the registry: University of California, San Francisco, Guselkumab (NCT04645355)
- 2026-06-23Results posted on the registry: AstraZeneca, Brazikumab low dose + Brazikumab high dose (NCT03759288)
- 2026-06-23Also stopped (terminated): AstraZeneca, Brazikumab low dose + Brazikumab high dose (NCT03759288)
- 2026-06-23Results posted on the registry: AstraZeneca, Brazikumab + Placebo (NCT03616821)
- 2026-06-23Also stopped (terminated): AstraZeneca, Brazikumab + Placebo (NCT03616821)
- 2026-06-23Results posted on the registry: AstraZeneca, Brazikumab Maintenance Dose + Brazikumab Induction Dose (NCT04277546)
- 2026-06-23Also stopped (terminated): AstraZeneca, Brazikumab Maintenance Dose + Brazikumab Induction Dose (NCT04277546)
- 2026-05-11Phase 3 first posted: Janssen Research & Development, LLC, JNJ-78934804 + Guselkumab (NCT07577843)
- 2026-05-11Phase 3 first posted: Janssen Research & Development, LLC, JNJ-78934804 + Guselkumab (NCT07577856)
- 2026-05-01Results posted on the registry: Janssen Research & Development, LLC, Guselkumab + Placebo (NCT06039189)
- 2026-04-06Phase 3 first posted: Qilu Pharmaceutical Co., Ltd., QL2106 injection + Tremfya® (NCT07511647)
- 2026-04-01Results posted on the registry: AstraZeneca, Brazikumab Induction Dose + Brazikumab Maintenance Dose (NCT03961815)
- 2026-04-01Also stopped (terminated): AstraZeneca, Brazikumab Induction Dose + Brazikumab Maintenance Dose (NCT03961815)
- 2026-03-30Phase 3 first posted: Janssen Research & Development, LLC, Guselkumab + Risankizumab (NCT07499232)
- 2026-02-24Results posted on the registry: AbbVie, Risankizumab + Placebo for Risankizumab (NCT05969223)
- 2026-02-04Results posted on the registry: Janssen Research & Development, LLC, Guselkumab + Placebo (NCT04882098)
- 2025-12-30Results posted on the registry: Eli Lilly and Company, Citrate-Free Mirikizumab (NCT06475729)
- 2025-12-15Results posted on the registry: Eli Lilly and Company, Mirikizumab (NCT04232553)
- 2025-12-09Results posted on the registry: Janssen Research & Development, LLC, Guselkumab Dose 1 + Guselkumab Dose 2 (NCT05528510)
- 2025-12-08Results posted on the registry: Janssen Research & Development, LLC, Guselkumab + Placebo (NCT04936308)
- 2025-11-25Results posted on the registry: Marcelo F. Di Carli, MD, FACC, Tildrakizumab (NCT04271540)
- 2025-10-24Results posted on the registry: Oregon Medical Research Center, risankizumab (NCT05283135)
- 2025-09-30Results posted on the registry: Eli Lilly and Company, Mirikizumab + Mirikizumab (NCT05767021)
- 2025-09-16Phase 3 first posted: First Affiliated Hospital of Wenzhou Medical University, Ustekinumab + Risankizumab (NCT07177118)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision