Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 19:22 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Safety and Efficacy in Participants With Metastatic BRAF-mutant Melanoma Treated With Encorafenib With and Without Binimetinib in Combination With Nivolumab and Low-dose Ipilimuma
NCT04655157 · Jason J. Luke, MD · PHASE1/PHASE2 · terminated · last registry update 2024-05-23 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Study terminated due to slow enrollment” | – | Registry record, Jason J. Luke, MD |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against BRAF within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-05-15Phase 3 first posted: Ruijin Hospital, Decitabine + Sorafenib (BAY-43-9006),giritinib (NCT06972641)
- 2025-05-13Results posted on the registry: Grupo Español Multidisciplinar de Melanoma, encorafenib + binimetinib (NCT03898908)
- 2025-05-02Also stopped (withdrawn): Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University, Vemurafenib (NCT02145910)
- 2025-04-27Also stopped (withdrawn): Medical University of South Carolina, ABC294640 (NCT02939807)
- 2025-04-13Also stopped (terminated): Novartis Pharmaceuticals, LXH254 + LTT462 (NCT02974725)
- 2025-03-30Also stopped (terminated): UNICANCER, Regorafenib then Trifluridine/Tipiracil + Trifluridine/Tipiracil then Regorafenib (NCT04450836)
- 2025-03-30Results posted on the registry: Fundacion Clinic per a la Recerca Biomédica, Cabozantinib (NCT04316182)
- 2025-03-11Also stopped (terminated): Great Novel Therapeutics Biotech & Medicals Corporation, Chidamide + Regorafenib (NCT05770882)
- 2025-02-28Results posted on the registry: Memorial Sloan Kettering Cancer Center, Vemurafenib + Copanlisib (NCT04462471)
- 2025-02-26Also stopped (terminated): Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Sorafenib (NCT04709380)
- 2025-02-24Phase 3 first posted: Shandong Cancer Hospital and Institute, Systemic therapy (Continuation of current first-line systemic therapy) + Systemic therapy (Early switch to second-line systemic therapy) (NCT06841172)
- 2025-02-12Also stopped (terminated): Georgetown University, Temozolomide + ABT-888 (NCT01205828)
- 2025-02-11Phase 3 first posted: Children's Oncology Group, Cyclophosphamide + Doxorubicin Hydrochloride (NCT06820957)
- 2025-02-11Phase 3 first posted: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, Dabrafenib and trametinib (combination) (NCT06819605)
- 2025-02-11Results posted on the registry: Robin Kate Kelley, Nivolumab + Sorafenib (NCT03439891)
- 2025-01-24Results posted on the registry: Kohei Shitara, Regorafenib + Nivolumab (NCT03406871)
- 2025-01-15Results posted on the registry: Institut du Cancer de Montpellier - Val d'Aurelle, Folfirinox + regorafenib (NCT03828799)
- 2025-01-08Also stopped (terminated): Strata Oncology, lorlatinib + encorafenib + binimetinib (NCT05097599)
- 2025-01-07Results posted on the registry: Eisai Inc., E7080 + Comparator Drug (NCT03477175)
- 2024-12-11Results posted on the registry: ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-12-11Also stopped (terminated): ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-08-22Results posted on the registry: ECOG-ACRIN Cancer Research Group, Dabrafenib mesylate + Hydroxychloroquine (NCT04527549)
- 2024-07-23Results posted on the registry: Bayer, Regorafenib, (Stivarga, BAY73-4506) + Nivolumab (Opdivo) (NCT04704154)
- 2024-06-26Phase 3 first posted: ECOG-ACRIN Cancer Research Group, Cabozantinib + Dabrafenib (NCT06475989)
- 2024-06-14Results posted on the registry: Hoffmann-La Roche, Alectinib + Vismodegib (NCT03498521)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision