Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 04:37 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies
NCT04690322 · University of Texas Southwestern Medical Center · PHASE4 · withdrawn · last registry update 2026-04-07 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Due to COVID-19 pandemic, recruitment was temporarily put on hold. We are withdrawing this registration due to a recent amendment to the protocol that includes major changes to data elements. A new registration will be submitted for the new protocol.” | – | Registry record, University of Texas Southwestern Medical Center |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against F8 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-11-09Phase 3 first posted: Pfizer, marstacimab (NCT07923981)
- 2026-11-06Also stopped (withdrawn): Emory University, Emicizumab + FEIBA (NCT04563520)
- 2026-10-15Also stopped (terminated): Octapharma, OCTA101 (NCT04046848)
- 2026-09-30Results posted on the registry: Grifols Biologicals, LLC, Alphanate SD/HT (NCT00555555)
- 2026-09-30Also stopped (terminated): Grifols Biologicals, LLC, Alphanate SD/HT (NCT00555555)
- 2026-09-24Phase 3 first posted: Hoffmann-La Roche, NXT007 (NCT07838194)
- 2026-08-14Results posted on the registry: Pfizer, PF-06741086 (NCT03938792)
- 2026-07-31Results posted on the registry: Laboratoire français de Fractionnement et de Biotechnologies, Coagulation Factor VIIa (Recombinant) (NCT05695391)
- 2026-07-31Also stopped (terminated): Laboratoire français de Fractionnement et de Biotechnologies, Coagulation Factor VIIa (Recombinant) (NCT05695391)
- 2026-07-06Phase 3 first posted: Hangzhou Gensciences Biopharmaceutical Co., Ltd., FRSW107 (NCT07684898)
- 2026-06-23Phase 3 first posted: Hangzhou Gensciences Biopharmaceutical Co., Ltd., FRSW107 (NCT07663903)
- 2026-05-07Also stopped (withdrawn): Ezeldeen Abuelkasem, Cryoprecipitate Intercept Fibrinogen Complex (IFC) + Cryoprecipitate Antihemophilic Factor (AHF) (NCT06764927)
- 2026-02-27Phase 3 first posted: Chulalongkorn University, Switching to low dose emicizumab (NCT07439055)
- 2026-02-20Results posted on the registry: Octapharma, Wilate (NCT04953884)
- 2026-02-18Phase 3 first posted: Hoffmann-La Roche, NXT007 + Human Coagulation Factor VIII (NCT07416526)
- 2025-11-12Results posted on the registry: Bayer, Damoctocog alfa-pegol is a recombinant B-domain deleted human coagulation FVIII variant site specifically conjugated with a 60 kDa, branched (30 kDa each) polyethylene glycol (PEG). (NCT05036278)
- 2025-11-06Results posted on the registry: Pfizer, Standard of Care FIX Replacement therapy + Standard of Care FVIII Replacement therapy (NCT03587116)
- 2025-09-30Results posted on the registry: Pfizer, SB-525 (PF-07055480) (NCT03061201)
- 2025-09-11Results posted on the registry: Baxalta now part of Shire, BAX 888 (NCT03370172)
- 2025-09-03Results posted on the registry: Baxalta now part of Shire, rVWF + rFVIII (NCT03879135)
- 2025-08-22Results posted on the registry: BioMarin Pharmaceutical, Valoctocogene Roxaparvovec (NCT03520712)
- 2025-08-22Also stopped (terminated): BioMarin Pharmaceutical, Valoctocogene Roxaparvovec (NCT03520712)
- 2025-08-19Phase 3 first posted: Takeda, VONVENDI + ADVATE (NCT07129343)
- 2025-08-17Results posted on the registry: Pfizer, PF-07055480 (giroctocogene fitelparovec): Recombinant AAV2/6 Human Factor VIII Gene Therapy (NCT04370054)
- 2025-07-28Results posted on the registry: Baxalta now part of Shire, PEGylated Recombinant Factor VIII + ITI (NCT02615691)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision