Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 00:19 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger
NCT04743804 · Alexion Pharmaceuticals, Inc. · PHASE3 · terminated · last registry update 2024-10-01 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Recruitment Challenges” | – | Registry record, Alexion Pharmaceuticals, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against C5 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-09-17Phase 3 first posted: Nanjing Chia-tai Tianqing Pharmaceutical, NTQ5082 capsules 200 mg + Eculizumab Injection (NCT07177859)
- 2025-09-10Also stopped (withdrawn): Tianjin Medical University General Hospital, Complement protein C5 inhibitor + IVMP (NCT06673394)
- 2025-09-04Phase 3 first posted: Regeneron Pharmaceuticals, Pozelimab + Cemdisiran (NCT07154745)
- 2025-07-09Also stopped (terminated): Alexion Pharmaceuticals, Inc., Ravulizumab + Placebo (NCT04999020)
- 2025-06-25Results posted on the registry: Regeneron Pharmaceuticals, Pozelimab + Cemdisiran (NCT04888507)
- 2025-06-17Phase 3 first posted: Alexion Pharmaceuticals, Inc., Ravulizumab (NCT07024563)
- 2025-06-05Also stopped (terminated): AKARI Therapeutics, nomacopan (rVA576) (NCT04784455)
- 2025-05-23Phase 3 first posted: Biocad, eculizumab (NCT06987864)
- 2025-05-15Results posted on the registry: AKARI Therapeutics, nomacopan (rVA576) (NCT04784455)
- 2025-05-04Results posted on the registry: AKARI Therapeutics, Coversin (NCT03427060)
- 2025-04-17Phase 3 first posted: Wuhan Createrna Science and Technology Co., Ltd, MY008211A tablets + Eculizumab Injection (NCT06932744)
- 2025-04-13Also stopped (terminated): BioCryst Pharmaceuticals, BCX9930 + Eculizumab (NCT04702568)
- 2025-04-10Also stopped (terminated): AKARI Therapeutics, rVA576 (NCT03829449)
- 2025-04-10Also stopped (terminated): AKARI Therapeutics, rVA576 + rVA576 (NCT04037891)
- 2025-04-09Also stopped (withdrawn): AKARI Therapeutics, nomacopan (rVA576) (NCT05061771)
- 2025-04-08Also stopped (terminated): Regeneron Pharmaceuticals, Cemdisiran + Eculizumab (NCT05131204)
- 2025-03-30Results posted on the registry: UCB Biopharma SRL, zilucoplan (RA101495) (NCT05514873)
- 2025-03-13Also stopped (terminated): IVERIC bio, Inc., Avacincaptad Pegol + Avastin (NCT05571267)
- 2025-03-12Results posted on the registry: AKARI Therapeutics, rVA576 (NCT03829449)
- 2025-03-07Results posted on the registry: BioCryst Pharmaceuticals, Eculizumab + Ravulizumab (NCT05116774)
- 2025-02-27Results posted on the registry: AKARI Therapeutics, rVA576 + rVA576 (NCT04037891)
- 2025-02-17Phase 3 first posted: Alexion Pharmaceuticals, Inc., Ravulizumab + Placebo (NCT06830798)
- 2025-02-11Results posted on the registry: InflaRx GmbH, Vilobelimab + Vilobelimab + pembrolizumab combination therapy (NCT04812535)
- 2025-02-11Also stopped (terminated): InflaRx GmbH, Vilobelimab + Vilobelimab + pembrolizumab combination therapy (NCT04812535)
- 2025-01-29Phase 3 first posted: Haisco Pharmaceutical Group Co., Ltd., HSK39297 tablets + Eculizumab Injection (NCT06799546)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision