Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 16:08 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780 · Syros Pharmaceuticals · PHASE3 · terminated · last registry update 2025-04-10 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “As per Sponsor decision, the study was terminated.” | – | Registry record, Syros Pharmaceuticals |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against RARB within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-03-31Phase 3 first posted: Quetzal Therapeutics, QTX-2101 + ATRA + IV arsenic trioxide (ATO) + ATRA (NCT07504458)
- 2026-03-31Phase 3 first posted: First Affiliated Hospital Xi'an Jiaotong University, ATRA + RIF (NCT07503730)
- 2025-12-22Phase 3 first posted: SDK Therapeutics, Inc., Oral ATO + IV Arsenic Trioxide (NCT07296445)
- 2025-12-18Also stopped (terminated): Mario Negri Institute for Pharmacological Research, all-trans retinoic acid + Anastrozole 1mg (NCT04113863)
- 2025-12-12Phase 3 first posted: Institute of Hematology & Blood Diseases Hospital, China, Avatrombopag+All trans retinoic acid + Avatrombopag (NCT07278908)
- 2025-11-14Results posted on the registry: University of Texas Southwestern Medical Center, a drug against RARB (NCT05493280)
- 2025-11-04Also stopped (terminated): Incyte Corporation, INCB059872 + all-trans retinoic acid (ATRA) (NCT02712905)
- 2025-11-04Also stopped (terminated): Icahn School of Medicine at Mount Sinai, Duobrii + Placebo (NCT05608499)
- 2025-10-31Results posted on the registry: Icahn School of Medicine at Mount Sinai, Duobrii + Placebo (NCT05608499)
- 2025-10-30Results posted on the registry: Bausch Health Americas, Inc., IDP-126 Gel + IDP-126 Vehicle Gel (NCT04892706)
- 2025-10-09Results posted on the registry: Sun Pharmaceutical Industries Limited, Winlevi (clascoterone) 1% & Adapalene 0.3% gel (NCT06336603)
- 2025-07-24Phase 3 first posted: James Thomas Pathoulas, Tretinoin 0.1% cream + Bland cream (non-drug) (NCT07084116)
- 2025-03-14Results posted on the registry: LEO Pharma, Delgocitinib + Toctino (NCT05259722)
- 2025-02-25Results posted on the registry: Hackensack Meridian Health, Daratumumab + Pomalidomide (NCT04700176)
- 2025-02-25Also stopped (terminated): Hackensack Meridian Health, Daratumumab + Pomalidomide (NCT04700176)
- 2025-02-24Results posted on the registry: Syros Pharmaceuticals, Tamibarotene + Venetoclax (NCT04905407)
- 2025-02-24Also stopped (terminated): Syros Pharmaceuticals, Tamibarotene + Venetoclax (NCT04905407)
- 2025-01-28Results posted on the registry: University of Washington, Isotretinoin + dextromethorphan (NCT03076021)
- 2025-01-22Phase 3 first posted: Hasanuddin University, tretinoin 0.025% + Z. officinale patch + tretinoin 0.025% cream (NCT06787222)
- 2025-01-15Phase 3 first posted: Dr.dr.Irma Bernadette, SpKK (K), Cleanser + Combination cream (NCT06775314)
- 2024-12-13Results posted on the registry: Syros Pharmaceuticals, Tamibarotene + Azacitidine (NCT02807558)
- 2024-12-09Also stopped (terminated): Taiho Oncology, Inc., TAS1440 + TAS1440 + ATRA (NCT04282668)
- 2024-11-26Phase 3 first posted: Centre Leon Berard, Vesanoid + Cisplatin (NCT06706401)
- 2024-10-04Results posted on the registry: BeiGene, Dinutuximab Beta + 13-cis-Retinoic Acid (NCT05373901)
- 2024-08-22Results posted on the registry: M.D. Anderson Cancer Center, Vorinostat + Isotretinoin (NCT00555399)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision