Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-12 07:05 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Evaluate the Efficacy and Safety of Oral Zavegepant in Migraine Prevention
NCT04804033 · Pfizer · PHASE2/PHASE3 · terminated · last registry update 2025-03-27 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Strategic decision to discontinue the study based on adjusted clinical development plan. This decision is not based on any safety concerns.” | – | Registry record, Pfizer |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against RAMP1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-03-05Results posted on the registry: Oregon Health and Science University, a drug against RAMP1 (NCT06422325)
- 2026-01-29Results posted on the registry: Pfizer, Zavegepant 10 mg IN (NCT05948085)
- 2026-01-13Also stopped (withdrawn): Pfizer, Zavegepant 10 mg + Placebo - Control 1 (NCT06103734)
- 2025-01-06Results posted on the registry: Pfizer, Zavegepant (NCT05960032)
- 2024-10-01Phase 3 first posted: Esbjerg Hospital - University Hospital of Southern Denmark, Pramlintide Acetate 1 MG/ML + Semaglutide Pen Injector (NCT06619015)
- 2024-10-01Results posted on the registry: Pfizer, Zavegepant 100mg non-enteric coated soft gel capsule + Zavegepant 100mg immediate release tablet (NCT06137703)
- 2024-07-19Results posted on the registry: Pfizer, Zavegepant + Placebo (NCT04987944)
- 2024-07-19Also stopped (terminated): Pfizer, Zavegepant + Placebo (NCT04987944)
- 2024-05-02Results posted on the registry: Pfizer, Zavegepant (BHV-3500) + Placebo (NCT04346615)
- 2024-05-02Also stopped (terminated): Pfizer, Zavegepant (BHV-3500) + Placebo (NCT04346615)
- 2024-03-27Results posted on the registry: Xeris Pharmaceuticals, PRAM9 + Regular Insulin + Pramlintide (NCT04074317)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision