Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 22:02 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study to Explore the Efficacy and Safety of Atezolizumab Plus Tiragolumab and Chemotherapy in 1st Line HER2 Negative Unresectable, Recurrent or Metastatic Gastric Cancer or Adenocarcinoma of Gastroesophageal Junction (GEJ)
NCT04933227 · Hoffmann-La Roche · PHASE2 · terminated · last registry update 2024-11-14 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Sponsor's decision to terminate the study after Stage 1; will not proceed with Stage 2.” | – | Registry record, Hoffmann-La Roche |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CD274 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-11-12Phase 3 first posted: Pfizer, PF-08634404 + Atezolizumab (NCT07226999)
- 2025-10-29Results posted on the registry: Hoffmann-La Roche, Tiragolumab + Atezolizumab (NCT04665856)
- 2025-10-27Phase 3 first posted: AstraZeneca, Rilvegostomig + Durvalumab (NCT07221253)
- 2025-10-20Results posted on the registry: M.D. Anderson Cancer Center, Avelumab + Berzosertib (NCT04266912)
- 2025-10-14Results posted on the registry: M.D. Anderson Cancer Center, Avelumab + Ivuxolimab (NCT03217747)
- 2025-09-29Phase 3 first posted: Boehringer Ingelheim, Zongertinib + Pembrolizumab (NCT07195695)
- 2025-09-23Results posted on the registry: National Cancer Institute (NCI), Capivasertib + Cediranib Maleate (NCT03660826)
- 2025-08-03Results posted on the registry: National Cancer Institute (NCI), Copanlisib Hydrochloride + Durvalumab (NCT03842228)
- 2025-07-20Results posted on the registry: UNC Lineberger Comprehensive Cancer Center, Durvalumab (NCT03529422)
- 2025-07-15Results posted on the registry: Medical College of Wisconsin, Concurrent Atezolizumab + Adjuvant Atezolizumab (NCT04477759)
- 2025-07-03Results posted on the registry: AstraZeneca, Durvalumab + Cisplatin (NCT03732677)
- 2025-06-18Phase 3 first posted: Hamilton Health Sciences Corporation, Chemotherapy/Radiation (NCT07027436)
- 2025-06-05Phase 3 first posted: Amgen, Tarlatamab + Durvalumab (NCT07005128)
- 2025-05-28Phase 3 first posted: AstraZeneca, Durvalumab (NCT06992609)
- 2025-04-10Phase 3 first posted: AstraZeneca, Tremelimumab + Rilvegostomig (NCT06921785)
- 2025-03-30Results posted on the registry: Hoffmann-La Roche, Atezolizumab + Cisplatin (NCT02486718)
- 2025-03-24Phase 3 first posted: Eli Lilly and Company, Olomorasib + Pembrolizumab (NCT06890598)
- 2025-03-04Results posted on the registry: National Cancer Institute (NCI), Atezolizumab + Bevacizumab (NCT02839707)
- 2025-02-24Phase 3 first posted: Shandong Cancer Hospital and Institute, Systemic therapy (Continuation of current first-line systemic therapy) + Systemic therapy (Early switch to second-line systemic therapy) (NCT06841172)
- 2025-02-21Phase 3 first posted: Gustave Roussy, Cancer Campus, Grand Paris, SoC-based immunotherapy (+/- chemotherapy) (NCT06840782)
- 2025-01-27Results posted on the registry: National Cancer Institute (NCI), Olaparib + Durvalumab (NCT04538378)
- 2024-12-13Phase 3 first posted: National Cancer Institute (NCI), Ceralasertib + Durvalumab (NCT06732401)
- 2024-12-02Phase 3 first posted: BioNTech SE, Pumitamig + Atezolizumab (NCT06712355)
- 2024-10-17Phase 3 first posted: Bristol-Myers Squibb, BMS-986489 (Atigotatug+Nivolumab) + Atezolizumab (NCT06646276)
- 2024-10-17Results posted on the registry: Hoffmann-La Roche, Atezolizumab + Trastuzumab (NCT04661150)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision