Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 22:37 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Efficacy and Safety of Benralizumab in Patients With Non-cystic Fibrosis Bronchiectasis
NCT05006573 · AstraZeneca · PHASE3 · terminated · last registry update 2025-07-20 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Due to the decision to stop recruitment early, enrolment into the MAHALE trial was terminated in August 2022; 139 patients were screened and 100 randomised to IP.” | – | Registry record, AstraZeneca |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against IL5RA within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-07-10Results posted on the registry: AstraZeneca, Benralizumab + Placebo (NCT04191304)
- 2026-05-18Results posted on the registry: GlaxoSmithKline, GSK3511294 (Depemokimab) + Mepolizumab (NCT04718389)
- 2026-03-03Phase 3 first posted: AstraZeneca, Benralizumab (NCT07444567)
- 2026-02-19Results posted on the registry: AstraZeneca, Benralizumab 30 mg + Matched placebo (NCT04157335)
- 2026-02-19Also stopped (terminated): AstraZeneca, Benralizumab 30 mg + Matched placebo (NCT04157335)
- 2025-08-22Results posted on the registry: McMaster University, Benralizumab + Placebo Control (NCT03563066)
- 2025-07-14Results posted on the registry: AstraZeneca, Benralizumab + Placebo (NCT05251909)
- 2025-07-14Also stopped (terminated): AstraZeneca, Benralizumab + Placebo (NCT05251909)
- 2025-04-29Results posted on the registry: Memorial Sloan Kettering Cancer Center, Benralizumab (NCT04552288)
- 2025-03-25Results posted on the registry: AstraZeneca, Benralizumab (NCT05552508)
- 2025-01-14Results posted on the registry: AstraZeneca, Benralizumab + Mepolizumab (NCT04157348)
- 2025-01-09Results posted on the registry: AstraZeneca, Symbicort® + Fasenra® (NCT04159519)
- 2024-12-27Phase 3 first posted: AstraZeneca, ICS-LABA + benralizumab (NCT06750289)
- 2024-12-11Results posted on the registry: AstraZeneca, Benralizumab (NCT05384938)
- 2024-11-29Results posted on the registry: AstraZeneca, Benralizumab + Placebo (NCT04612790)
- 2024-11-29Also stopped (terminated): AstraZeneca, Benralizumab + Placebo (NCT04612790)
- 2024-08-29Results posted on the registry: Memorial Sloan Kettering Cancer Center, Benralizumab + fulvestrant or AIs) and PI3K inhibition (alpelisib) (NCT05966584)
- 2024-08-29Also stopped (terminated): Memorial Sloan Kettering Cancer Center, Benralizumab + fulvestrant or AIs) and PI3K inhibition (alpelisib) (NCT05966584)
- 2024-07-22Phase 3 first posted: AstraZeneca, Benralizumab (NCT06512883)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision