Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:28 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors
NCT05071183 · Turning Point Therapeutics, Inc. · PHASE1/PHASE2 · terminated · last registry update 2024-04-02 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Inability to achieve and optimize a dose that could provide a positive benefit risk profile” | – | Registry record, Turning Point Therapeutics, Inc. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against NTRK1 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-04-01Also stopped (withdrawn): Turning Point Therapeutics, Inc., TPX-0005 + Metformin Hydrochloride (NCT05828303)
- 2025-03-30Also stopped (terminated): UNICANCER, Regorafenib then Trifluridine/Tipiracil + Trifluridine/Tipiracil then Regorafenib (NCT04450836)
- 2025-03-11Also stopped (terminated): Great Novel Therapeutics Biotech & Medicals Corporation, Chidamide + Regorafenib (NCT05770882)
- 2025-02-24Phase 3 first posted: Shandong Cancer Hospital and Institute, Systemic therapy (Continuation of current first-line systemic therapy) + Systemic therapy (Early switch to second-line systemic therapy) (NCT06841172)
- 2025-02-11Phase 3 first posted: Children's Oncology Group, Cyclophosphamide + Doxorubicin Hydrochloride (NCT06820957)
- 2025-01-24Results posted on the registry: Kohei Shitara, Regorafenib + Nivolumab (NCT03406871)
- 2025-01-15Results posted on the registry: Institut du Cancer de Montpellier - Val d'Aurelle, Folfirinox + regorafenib (NCT03828799)
- 2025-01-08Results posted on the registry: Genentech, Inc., Entrectinib + Inavolisib (NCT04632992)
- 2024-12-11Results posted on the registry: ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-12-11Also stopped (terminated): ImmunityBio, Inc., Aldoxorubicin Hydrochloride + ALT-803 (NCT03563157)
- 2024-12-04Results posted on the registry: Dompé Farmaceutici S.p.A, Cenegermin (NCT05136170)
- 2024-12-02Also stopped (withdrawn): Dompé Farmaceutici S.p.A, OXERVATE® 0.002% (NCT06411145)
- 2024-11-21Also stopped (withdrawn): City of Hope Medical Center, Balstilimab + Botensilimab (NCT06575725)
- 2024-10-15Results posted on the registry: EpicentRx, Inc., RRx-001 + Regorafenib (NCT02096354)
- 2024-10-04Results posted on the registry: Asan Medical Center, Regorafenib (NCT02175095)
- 2024-09-27Results posted on the registry: Academic and Community Cancer Research United, Cetuximab + Irinotecan (NCT04117945)
- 2024-09-25Results posted on the registry: Hutchison Medipharma Limited, Fruquintinib (HMPL-013) (NCT03251378)
- 2024-08-21Phase 3 first posted: Nuvation Bio Inc., Taletrectinib + Crizotinib (NCT06564324)
- 2024-08-02Results posted on the registry: Hoffmann-La Roche, entrectinib (NCT04226833)
- 2024-07-23Results posted on the registry: Bayer, Regorafenib, (Stivarga, BAY73-4506) + Nivolumab (Opdivo) (NCT04704154)
- 2024-06-26Results posted on the registry: Wake Forest University Health Sciences, Regorafenib (NCT02581059)
- 2024-06-26Also stopped (terminated): Wake Forest University Health Sciences, Regorafenib (NCT02581059)
- 2024-06-14Results posted on the registry: Hoffmann-La Roche, Alectinib + Vismodegib (NCT03498521)
- 2024-06-07Results posted on the registry: Dompé Farmaceutici S.p.A, Oxervate (NCT05133180)
- 2024-06-05Results posted on the registry: Theseus Pharmaceuticals, THE-630 (NCT05160168)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision