Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 15:58 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)
NCT05144009 · ADC Therapeutics S.A. · PHASE2 · terminated · last registry update 2025-01-30 · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “The benefit-risk profile does not support continuation of the LOTIS-9 trial.” | – | Registry record, ADC Therapeutics S.A. |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against CD19 within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2026-01-29Results posted on the registry: Incyte Corporation, tafasitamab + parsaclisib (NCT04809467)
- 2026-01-29Results posted on the registry: Patrick C. Johnson, MD, ACALABRUTINIB + LISOCABTAGENE MARALEUCEL (NCT05583149)
- 2026-01-23Results posted on the registry: Masonic Cancer Center, University of Minnesota, KYMRIAH + YESCARTA (NCT03642626)
- 2025-12-23Results posted on the registry: Kite, A Gilead Company, Axicabtagene ciloleucel + Cyclophosphamide (NCT03105336)
- 2025-12-22Phase 3 first posted: Bambino Gesù Hospital and Research Institute, Ruxolitinib + Blinatumomab (NCT07297914)
- 2025-11-13Also stopped (suspended): City of Hope Medical Center, Chimeric Antigen Receptor T-Cell Therapy + Tafasitamab (NCT05993611)
- 2025-11-10Results posted on the registry: University of California, San Diego, blinatumomab + pembrolizumab (NCT03160079)
- 2025-10-31Phase 3 first posted: Amgen, Blinatumomab + Blinatumomab (NCT07223190)
- 2025-10-23Results posted on the registry: Fred Hutchinson Cancer Center, Anakinra (NCT04359784)
- 2025-10-03Also stopped (withdrawn): Karyopharm Therapeutics Inc, Selinexor + Rituximab (NCT04607772)
- 2025-09-23Phase 3 first posted: Lyell Immunopharma, Inc., rondecabtagene autoleucel + axicabtagene ciloleucel (NCT07188558)
- 2025-09-22Results posted on the registry: St. Jude Children's Research Hospital, Venetoclax + Navitoclax (NCT05192889)
- 2025-09-05Results posted on the registry: Pfizer, Maplirpacept + Tafasitamab (NCT05626322)
- 2025-09-05Also stopped (terminated): Pfizer, Maplirpacept + Tafasitamab (NCT05626322)
- 2025-09-04Also stopped (terminated): Universität Münster, Bridging Therapy + Lymphodepletion (NCT06912529)
- 2025-09-03Phase 3 first posted: Institute of Hematology & Blood Diseases Hospital, China, olverembatinib (NCT07152041)
- 2025-08-20Phase 3 first posted: Tianjin Medical University General Hospital, Slow-tapering glucocorticoids + Inebilizumab + Rapid-tapering glucocorticoids + Inebilizumab (NCT07132398)
- 2025-08-03Results posted on the registry: Celgene, Standard of Care + JCAR017 (NCT03575351)
- 2025-07-28Results posted on the registry: Incyte Corporation, Tafasitamab + Lenalidomide (NCT05222555)
- 2025-07-17Results posted on the registry: Incyte Corporation, Rituximab (RTX) + Tafasitamab (NCT02763319)
- 2025-07-10Phase 3 first posted: Shanxi Bethune Hospital, Induction Therapy Regimen + Pre-Treatment Regimen (NCT07059156)
- 2025-06-25Results posted on the registry: Amgen, Inebilizumab (NCT04540497)
- 2025-05-25Also stopped (terminated): Memorial Sloan Kettering Cancer Center, Tafasitamab + Lenalidomide (NCT05788289)
- 2025-05-23Results posted on the registry: Massachusetts General Hospital, Blinatumomab (NCT02811679)
- 2025-05-23Also stopped (terminated): Massachusetts General Hospital, Blinatumomab (NCT02811679)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision