Live from ClinicalTrials.gov + Open Targets, fetched 2026-11-11 18:43 UTC. Every row links to its source record.
Postmortem · what the sponsor and named sources said, kept apart from what merely happened at the same time
Phase 3 Study of Futuximab/Modotuximab in Combination With Trifluridine/Tipiracil Versus Trifluridine/Tipiracil Single Agent in Participants With Previously Treated Metastatic Colorectal Cancer
NCT05223673 · Institut de Recherches Internationales Servier · PHASE3 · terminated · last registry update 2024-08-20 · Colorectal cancer · Decision brief
No research has been run for this trial yet, so only the registry's own reason and the timeline are shown.
What was said, and by whom
Stated is the sponsor's own words; Reported is a named third party. The category is our label from a fixed list; the quote is the evidence.
| Kind | Quote | Our category | Source |
|---|---|---|---|
| Stated | “Sponsor decided to discontinue the study during the Lead-In part and the Phase III part was not started due to strategic reasons.” | – | Registry record, Institut de Recherches Internationales Servier |
Also happening at the time. Not shown to be a cause.
Registry events on other trials of drugs against TYMP in colorectal cancer within 12 months either side of this trial's last update, live from ClinicalTrials.gov. Nothing here was stated as a reason.
- 2025-05-28Phase 3 first posted: Second Affiliated Hospital, Zhejiang University, School of Medicine, Trifluridine/Tipiracil + Regorafenib + Trifluridine/tipiracil + bevacizumab (NCT06992648)
- 2025-03-30Also stopped (terminated): UNICANCER, Regorafenib then Trifluridine/Tipiracil + Trifluridine/Tipiracil then Regorafenib (NCT04450836)
- 2025-02-27Phase 3 first posted: Shandong Cancer Hospital and Institute, TAS-102 + Capecitabine (NCT06850090)
- 2024-09-25Results posted on the registry: Hutchison Medipharma Limited, Fruquintinib (HMPL-013) (NCT03251378)
- 2024-09-19Also stopped (withdrawn): Academic and Community Cancer Research United, Trastuzumab + Trifluridine and Tipiracil Hydrochloride (NCT05356897)
- 2024-05-21Results posted on the registry: Academic and Community Cancer Research United, Panitumumab + Regorafenib (NCT03992456)
- 2024-05-02Also stopped (terminated): Elevar Therapeutics, Rivoceranib + Trifluridine/Tipiracil (NCT04073615)
- 2024-04-09Results posted on the registry: Merck Sharp & Dohme LLC, pembrolizumab + lenvatinib (NCT04776148)
- 2024-04-02Phase 3 first posted: Biotech Pharmaceutical Co., Ltd., Nimotuzumab injection + Placebo (NCT06343116)
- 2024-01-10Phase 3 first posted: Suzhou Suncadia Biopharmaceuticals Co., Ltd., SHR-A1811 + TAS-102, Regorafenib , Fruquintinib (NCT06199973)
- 2023-12-26Results posted on the registry: Taiho Oncology, Inc., Trifluridine/Tipiracil + Bevacizumab (NCT04737187)
- 2023-11-03Results posted on the registry: Karyopharm Therapeutics Inc, Selinexor + Pembrolizumab (NCT04854434)
- 2023-11-03Also stopped (terminated): Karyopharm Therapeutics Inc, Selinexor + Pembrolizumab (NCT04854434)
- 2023-09-18Also stopped (terminated): GERCOR - Multidisciplinary Oncology Cooperative Group, Trifluridine/Tipiracil + Oxaliplatin (NCT04894123)
What is not public
- Internal portfolio and board discussions
- Unpublished trial data and interim analyses
- Terms of any partner or licence decision